PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31717983-3 2019 Arachidonate 15-lipoxygenase (15-LOX-1) enzyme is involved in polyunsaturated fatty acid metabolism. Fatty Acids, Unsaturated 62-88 arachidonate 15-lipoxygenase Homo sapiens 0-28 33396527-5 2020 Our results also revealed that arachidonic acid, linoleic acid and docosahexanoic acid are key polyunsaturated fatty acid substrates for ALOX15. Fatty Acids, Unsaturated 95-121 arachidonate 15-lipoxygenase Homo sapiens 137-143 33038835-1 2020 Double lipoxygenation of polyunsaturated fatty acids having at least three methylene-interrupted double bonds can be made by two lipoxygenases, e.g. 5- and 12-LOX, or 15-LOX only, followed by reduction of the hydroperoxide products through the glutathione peroxidase action. Fatty Acids, Unsaturated 25-52 arachidonate 15-lipoxygenase Homo sapiens 156-162 33038835-1 2020 Double lipoxygenation of polyunsaturated fatty acids having at least three methylene-interrupted double bonds can be made by two lipoxygenases, e.g. 5- and 12-LOX, or 15-LOX only, followed by reduction of the hydroperoxide products through the glutathione peroxidase action. Fatty Acids, Unsaturated 25-52 arachidonate 15-lipoxygenase Homo sapiens 167-173 31717983-3 2019 Arachidonate 15-lipoxygenase (15-LOX-1) enzyme is involved in polyunsaturated fatty acid metabolism. Fatty Acids, Unsaturated 62-88 arachidonate 15-lipoxygenase Homo sapiens 30-38 31903039-3 2019 The 12/15-lipoxygenase (LOX) is special in that it can directly oxidize lipid membranes containing polyunsaturated fatty acids, without the preceding action of a phospholipase, leading to the direct attack on membranous organelles, such as mitochondria. Fatty Acids, Unsaturated 99-126 arachidonate 15-lipoxygenase Homo sapiens 4-22 31903039-3 2019 The 12/15-lipoxygenase (LOX) is special in that it can directly oxidize lipid membranes containing polyunsaturated fatty acids, without the preceding action of a phospholipase, leading to the direct attack on membranous organelles, such as mitochondria. Fatty Acids, Unsaturated 99-126 arachidonate 15-lipoxygenase Homo sapiens 24-27 31231138-1 2019 Human 15-lipoxygenase-1 (15-LOX-1) belongs to the class of lipoxygenases, which catalyze oxygenation of polyunsaturated fatty acids, such as arachidonic and linoleic acid. Fatty Acids, Unsaturated 104-131 arachidonate 15-lipoxygenase Homo sapiens 6-23 31231138-1 2019 Human 15-lipoxygenase-1 (15-LOX-1) belongs to the class of lipoxygenases, which catalyze oxygenation of polyunsaturated fatty acids, such as arachidonic and linoleic acid. Fatty Acids, Unsaturated 104-131 arachidonate 15-lipoxygenase Homo sapiens 25-33 30472260-1 2019 12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. Fatty Acids, Unsaturated 60-87 arachidonate 15-lipoxygenase Homo sapiens 0-18 30347209-1 2019 12-lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of arachidonic acid and other poly-unsaturated fatty acids to both pro- and anti-inflammatory lipid mediators. Fatty Acids, Unsaturated 120-148 arachidonate 15-lipoxygenase Homo sapiens 0-15 30347209-1 2019 12-lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of arachidonic acid and other poly-unsaturated fatty acids to both pro- and anti-inflammatory lipid mediators. Fatty Acids, Unsaturated 120-148 arachidonate 15-lipoxygenase Homo sapiens 17-23 30472260-1 2019 12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. Fatty Acids, Unsaturated 60-87 arachidonate 15-lipoxygenase Homo sapiens 20-29 27647374-1 2016 Human 15-lipoxygenase-1 (h15-LOX-1 or h12/15-LOX) reacts with polyunsaturated fatty acids and produces bioactive lipid derivatives that are implicated in many important human diseases. Fatty Acids, Unsaturated 62-89 arachidonate 15-lipoxygenase Homo sapiens 26-34 29882120-3 2018 15-Lipoxygenase (15-LOX) is an enzyme which reacts with polyunsaturated fatty acids and produces metabolites that are implicated in many important human diseases, such as cancer. Fatty Acids, Unsaturated 56-83 arachidonate 15-lipoxygenase Homo sapiens 0-15 29882120-3 2018 15-Lipoxygenase (15-LOX) is an enzyme which reacts with polyunsaturated fatty acids and produces metabolites that are implicated in many important human diseases, such as cancer. Fatty Acids, Unsaturated 56-83 arachidonate 15-lipoxygenase Homo sapiens 17-23 28400162-3 2017 Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA). Fatty Acids, Unsaturated 231-258 arachidonate 15-lipoxygenase Homo sapiens 22-28 28400162-3 2017 Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA). Fatty Acids, Unsaturated 260-265 arachidonate 15-lipoxygenase Homo sapiens 22-28 27480217-1 2017 12/15-Lipoxygenase (12/15-LOX) mediates the enzymatic oxidation of polyunsaturated fatty acids, thereby contributing to the generation of various bioactive lipid mediators. Fatty Acids, Unsaturated 67-94 arachidonate 15-lipoxygenase Homo sapiens 0-18 27480217-1 2017 12/15-Lipoxygenase (12/15-LOX) mediates the enzymatic oxidation of polyunsaturated fatty acids, thereby contributing to the generation of various bioactive lipid mediators. Fatty Acids, Unsaturated 67-94 arachidonate 15-lipoxygenase Homo sapiens 20-29 29627380-1 2018 The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders. Fatty Acids, Unsaturated 54-81 arachidonate 15-lipoxygenase Homo sapiens 4-22 29627380-1 2018 The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders. Fatty Acids, Unsaturated 54-81 arachidonate 15-lipoxygenase Homo sapiens 24-33 30197642-1 2018 Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13. Fatty Acids, Unsaturated 119-146 arachidonate 15-lipoxygenase Homo sapiens 0-28 30197642-1 2018 Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13. Fatty Acids, Unsaturated 119-146 arachidonate 15-lipoxygenase Homo sapiens 30-36 29546268-3 2018 One of the key enzymes involved in the metabolism of polyunsaturated fatty acids to 4HNE in somatic cells is arachidonate 15-lipoxygenase (ALOX15). Fatty Acids, Unsaturated 53-80 arachidonate 15-lipoxygenase Homo sapiens 109-137 29546268-3 2018 One of the key enzymes involved in the metabolism of polyunsaturated fatty acids to 4HNE in somatic cells is arachidonate 15-lipoxygenase (ALOX15). Fatty Acids, Unsaturated 53-80 arachidonate 15-lipoxygenase Homo sapiens 139-145 29235036-1 2018 The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) is enriched in neural membranes of the CNS, and recent studies have shown a role of DHA metabolism by 15-lipoxygenase-1 (Alox15) in prefrontal cortex resolvin D1 formation, hippocampo-prefrontal cortical long-term-potentiation, spatial working memory, and anti-nociception/anxiety. Fatty Acids, Unsaturated 12-38 arachidonate 15-lipoxygenase Homo sapiens 188-194 23285160-1 2012 15-Lipoxygenase-1 (15-LOX-1) oxidizes polyunsaturated fatty acids to a rich spectrum of biologically active metabolites and is implicated in physiological membrane remodelling, inflammation and apoptosis. Fatty Acids, Unsaturated 38-65 arachidonate 15-lipoxygenase Homo sapiens 0-17 24465480-1 2014 Arachidonate 15-lipoxygenase-1 (ALOX15) oxygenates polyunsaturated fatty acids and bio-membranes, generating multiple lipid signalling mediators involved in inflammation. Fatty Acids, Unsaturated 51-78 arachidonate 15-lipoxygenase Homo sapiens 32-38 23055198-1 2013 15-Lipoxygenase-1 (15-Lox-1) is a key enzyme mediating oxidative metabolism of polyunsaturated fatty acids and has attracted considerable interest as a potential target for the induction of apoptosis in cancer cells. Fatty Acids, Unsaturated 79-106 arachidonate 15-lipoxygenase Homo sapiens 0-17 23055198-1 2013 15-Lipoxygenase-1 (15-Lox-1) is a key enzyme mediating oxidative metabolism of polyunsaturated fatty acids and has attracted considerable interest as a potential target for the induction of apoptosis in cancer cells. Fatty Acids, Unsaturated 79-106 arachidonate 15-lipoxygenase Homo sapiens 19-27 23285160-1 2012 15-Lipoxygenase-1 (15-LOX-1) oxidizes polyunsaturated fatty acids to a rich spectrum of biologically active metabolites and is implicated in physiological membrane remodelling, inflammation and apoptosis. Fatty Acids, Unsaturated 38-65 arachidonate 15-lipoxygenase Homo sapiens 19-27 20581078-1 2010 15-Lipoxygenase-1 catalyzes the introduction of molecular oxygen into polyunsaturated fatty acids to form a lipid hydroperoxide. Fatty Acids, Unsaturated 70-97 arachidonate 15-lipoxygenase Homo sapiens 0-15 7615823-3 1995 To assess whether oxidized lipids are indeed formed by the action of 15-lipoxygenase on polyunsaturated fatty acids (PUFAs) in vivo, we have used a sensitive and specific method (chiral phase HPLC) to analyze the lipid oxidation products present in human atherosclerotic lesions. Fatty Acids, Unsaturated 88-115 arachidonate 15-lipoxygenase Homo sapiens 69-84 7615823-3 1995 To assess whether oxidized lipids are indeed formed by the action of 15-lipoxygenase on polyunsaturated fatty acids (PUFAs) in vivo, we have used a sensitive and specific method (chiral phase HPLC) to analyze the lipid oxidation products present in human atherosclerotic lesions. Fatty Acids, Unsaturated 117-122 arachidonate 15-lipoxygenase Homo sapiens 69-84 34655995-1 2021 12/15-lipoxygenase (12/15-LOX) plays an essential role in oxidative conversion of polyunsaturated fatty acids into various bioactive lipid molecules. Fatty Acids, Unsaturated 82-109 arachidonate 15-lipoxygenase Homo sapiens 0-18 34655995-1 2021 12/15-lipoxygenase (12/15-LOX) plays an essential role in oxidative conversion of polyunsaturated fatty acids into various bioactive lipid molecules. Fatty Acids, Unsaturated 82-109 arachidonate 15-lipoxygenase Homo sapiens 20-29 15572846-8 2004 Since the 5-lipoxygenase pathway is abundantly expressed in atherosclerotic lesions, and 12/15-lipoxygenase is able to oxygenate polyunsaturated fatty acid esterified in the membranous phospholipids, 5-lipoxygenase or 12/15-lipoxygenase inhibitors may prevent progression of atherosclerosis. Fatty Acids, Unsaturated 129-155 arachidonate 15-lipoxygenase Homo sapiens 89-107 15572846-8 2004 Since the 5-lipoxygenase pathway is abundantly expressed in atherosclerotic lesions, and 12/15-lipoxygenase is able to oxygenate polyunsaturated fatty acid esterified in the membranous phospholipids, 5-lipoxygenase or 12/15-lipoxygenase inhibitors may prevent progression of atherosclerosis. Fatty Acids, Unsaturated 129-155 arachidonate 15-lipoxygenase Homo sapiens 218-236 11966935-1 2002 BACKGROUND: Polyunsaturated fatty acids have the potential to attenuate inflammation by the synthesis of mediators of the 15-lipoxygenase pathways, which show opposite effects to the pro-inflammatory arachidonic acid metabolites such as leukotriene B4 (LTB4). Fatty Acids, Unsaturated 12-39 arachidonate 15-lipoxygenase Homo sapiens 122-137 34838055-1 2021 15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been proposed recently as a new molecular target for regulating cancer cell growth. Fatty Acids, Unsaturated 64-87 arachidonate 15-lipoxygenase Homo sapiens 0-15 34486255-1 2021 Arachidonic acid 15-lipoxygenase (ALOX15) is an enzyme that can oxidize polyunsaturated fatty acids. Fatty Acids, Unsaturated 72-99 arachidonate 15-lipoxygenase Homo sapiens 34-40 35577309-3 2022 15-lipoxygenase accounts as a key enzyme in metabolizing polyunsaturated fatty acids that generate various inflammatory lipid metabolites. Fatty Acids, Unsaturated 57-84 arachidonate 15-lipoxygenase Homo sapiens 0-15