PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16554040-10	2006	This raises the possibility that increased SREBP-1 expression secondary to aging-related decline of polyunsaturated fatty acid (PUFA) might compensate for the reduction of FAS expression in brain.	Fatty Acids, Unsaturated	100-126	sterol regulatory element binding transcription factor 1	Rattus norvegicus	43-50	
26327595-4	2015	Polyunsaturated fatty acids of marine origin (n-3 PUFA) prevent induction of SREBP-1c by insulin thereby reducing plasma and hepatic triglycerides.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Rattus norvegicus	77-85	
17393226-6	2007	Moreover, this demonstrates the existence of an interaction between unsaturated fatty acids and cholesterol metabolism performed by the insulin/SREBP-1c system and LXR/RXR.	Fatty Acids, Unsaturated	68-91	sterol regulatory element binding transcription factor 1	Rattus norvegicus	144-152	
21169224-5	2011	Both PUFA-enriched remnants and nonesterified PUFA inhibited the expression and maturation of sterol response element binding protein-1c (SREBP-1c) and the expression of lipogenic genes regulated by this transcription factor.	Fatty Acids, Unsaturated	5-9	sterol regulatory element binding transcription factor 1	Rattus norvegicus	94-136	
21169224-5	2011	Both PUFA-enriched remnants and nonesterified PUFA inhibited the expression and maturation of sterol response element binding protein-1c (SREBP-1c) and the expression of lipogenic genes regulated by this transcription factor.	Fatty Acids, Unsaturated	5-9	sterol regulatory element binding transcription factor 1	Rattus norvegicus	138-146	
19716432-2	2009	Conversely, polyunsaturated fatty acids (PUFA) decrease lipogenic gene transcription via suppression of SREBP-1c.	Fatty Acids, Unsaturated	12-39	sterol regulatory element binding transcription factor 1	Rattus norvegicus	104-112	
19716432-2	2009	Conversely, polyunsaturated fatty acids (PUFA) decrease lipogenic gene transcription via suppression of SREBP-1c.	Fatty Acids, Unsaturated	41-45	sterol regulatory element binding transcription factor 1	Rattus norvegicus	104-112	
16554040-10	2006	This raises the possibility that increased SREBP-1 expression secondary to aging-related decline of polyunsaturated fatty acid (PUFA) might compensate for the reduction of FAS expression in brain.	Fatty Acids, Unsaturated	128-132	sterol regulatory element binding transcription factor 1	Rattus norvegicus	43-50	
15331573-12	2004	This study clearly demonstrates that substitution of dietary polyunsaturated fatty acid for carbohydrate in the corpulent JCR:LA-cp rat reduces de novo lipogenesis, at least in part, by reducing hepatic expression of SREBP-1c and that strategies directed toward reducing SREBP-1c expression in the liver may mitigate the adverse effects of hyperinsulinemia on hepatic lipid production.	Fatty Acids, Unsaturated	61-87	sterol regulatory element binding transcription factor 1	Rattus norvegicus	217-225	
15331573-12	2004	This study clearly demonstrates that substitution of dietary polyunsaturated fatty acid for carbohydrate in the corpulent JCR:LA-cp rat reduces de novo lipogenesis, at least in part, by reducing hepatic expression of SREBP-1c and that strategies directed toward reducing SREBP-1c expression in the liver may mitigate the adverse effects of hyperinsulinemia on hepatic lipid production.	Fatty Acids, Unsaturated	61-87	sterol regulatory element binding transcription factor 1	Rattus norvegicus	271-279	
12917410-13	2003	The unsaturated fatty acid suppression of SREBP-1 and its targeted lipogenic genes is independent of LXRalpha	Fatty Acids, Unsaturated	4-26	sterol regulatory element binding transcription factor 1	Rattus norvegicus	42-49	
12421847-1	2002	Male Sprague-Dawley rats, trained to consume their daily energy needs in a single 3-h meal (0900-1200 h), were used to examine the hypothesis that polyunsaturated fatty acids (PUFA) lowered the nuclear content of sterol regulatory element binding protein (SREBP)-1 and/or -2 by suppressing the proteolytic release of mature SREBP from the membrane-anchored precursor pool.	Fatty Acids, Unsaturated	147-174	sterol regulatory element binding transcription factor 1	Rattus norvegicus	256-264	
12421847-2	2002	The nuclear concentrations of hepatic SREBP-1 and -2 were 50 and 42% lower (P < 0.05) in rats that consumed a single PUFA-supplemented meal (i.e., 10 g fish oil/100 g fat-free diet) than in rats fed the fat-free diet alone.	Fatty Acids, Unsaturated	120-124	sterol regulatory element binding transcription factor 1	Rattus norvegicus	38-52	
11124951-0	2001	Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Rattus norvegicus	45-88	
11124951-1	2001	The reduction in hepatic abundance of sterol regulatory element binding protein-1 (SREBP-1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA) appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene transcription.	Fatty Acids, Unsaturated	142-169	sterol regulatory element binding transcription factor 1	Rattus norvegicus	38-81	
11124951-1	2001	The reduction in hepatic abundance of sterol regulatory element binding protein-1 (SREBP-1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA) appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene transcription.	Fatty Acids, Unsaturated	142-169	sterol regulatory element binding transcription factor 1	Rattus norvegicus	83-90	
11124951-1	2001	The reduction in hepatic abundance of sterol regulatory element binding protein-1 (SREBP-1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA) appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene transcription.	Fatty Acids, Unsaturated	171-175	sterol regulatory element binding transcription factor 1	Rattus norvegicus	38-81	
11124951-1	2001	The reduction in hepatic abundance of sterol regulatory element binding protein-1 (SREBP-1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA) appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene transcription.	Fatty Acids, Unsaturated	171-175	sterol regulatory element binding transcription factor 1	Rattus norvegicus	83-90	
12488438-2	2003	In adult animals, insulin and oxysterols induce SREBP-1c gene transcription, whereas polyunsaturated fatty acids suppress the nuclear content of SREBP-1c through pre-translational regulatory mechanisms.	Fatty Acids, Unsaturated	85-112	sterol regulatory element binding transcription factor 1	Rattus norvegicus	145-153	
11779162-6	2002	This is the first report that insulin, cAMP, and polyunsaturated fatty acids modulate the proximal SREBP-1c promoter in rat hepatocytes mirroring physiological regulation of SREBP-1c in vivo.	Fatty Acids, Unsaturated	49-76	sterol regulatory element binding transcription factor 1	Rattus norvegicus	99-107	
11779162-6	2002	This is the first report that insulin, cAMP, and polyunsaturated fatty acids modulate the proximal SREBP-1c promoter in rat hepatocytes mirroring physiological regulation of SREBP-1c in vivo.	Fatty Acids, Unsaturated	49-76	sterol regulatory element binding transcription factor 1	Rattus norvegicus	174-182