PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24273738-5 2013 The agents used to promote CYP2E1 -dependent toxicity were a polyunsaturated fatty acid, arachidonic acid (AA), buthionine sulfoximine (BSO), which depletes GSH, and CCl4, which is metabolized to the CCl3 radical. Fatty Acids, Unsaturated 61-87 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 27-33 16958665-6 2006 Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells that express CYP2E1 (E47 cells) but not control HepG2 cells. Fatty Acids, Unsaturated 9-36 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 89-95 23400918-6 2013 Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells which express CYP2E1 (E47 cells) but not control C34HepG2 cells which do not express CYP2E1.Toxicity was associated with enhanced oxidant stress and could be prevented by antioxidants and potentiated if glutathione (GSH) was removed. Fatty Acids, Unsaturated 9-36 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 90-96 19671018-7 2009 Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells, which express CYP2E1 (E47 cells) but not control C34HepG2 cells, which do not express CYP2E1. Fatty Acids, Unsaturated 9-36 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 91-97 16019049-3 2005 Addition of ethanol or an unsaturated fatty acid such as arachidonic acid or iron was toxic to the CYP2E1-expressing cells but not control cells. Fatty Acids, Unsaturated 26-48 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 99-105 14744237-2 2004 Ethanol, polyunsaturated fatty acids, and iron were found to be cytotoxic in HepG2 cells that overexpress CYP2E1. Fatty Acids, Unsaturated 9-36 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 106-112 14767997-7 2004 Similar to menadione, the polyunsaturated fatty acid (PUFA) arachidonic acid (AA) induced an increased activation of ERK1/2 in hepatocytes that overexpressed CYP2E1. Fatty Acids, Unsaturated 26-52 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 158-164 14767997-7 2004 Similar to menadione, the polyunsaturated fatty acid (PUFA) arachidonic acid (AA) induced an increased activation of ERK1/2 in hepatocytes that overexpressed CYP2E1. Fatty Acids, Unsaturated 54-58 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 158-164 14767997-8 2004 However, CYP2E1-overexpressing cells were sensitized to necrotic death from AA and the PUFA gamma-linolenic acid, but not from saturated or monounsaturated fatty acids. Fatty Acids, Unsaturated 87-91 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 9-15 11259624-5 2001 Addition of a polyunsaturated fatty acid such as arachidonic acid (AA) to HepG2 cells resulted in loss of cell viability, especially in cells expressing CYP2E1 (E47 cells). Fatty Acids, Unsaturated 14-40 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 153-159 12957295-14 2003 These results support the suggestion that low concentrations of iron and polyunsaturated fatty acids can act as priming or sensitizing factors for CYP2E1-induced injury in HepG2 cells and hepatocytes. Fatty Acids, Unsaturated 73-100 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 147-153 11744327-3 2001 Addition of ethanol or an unsaturated fatty acid such as arachidonic acid or iron was toxic to the CYP2E1-expressing cells but not control cells. Fatty Acids, Unsaturated 26-48 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 99-105 11275473-1 2001 Polyunsaturated fatty acids such as arachidonic acid were previously shown to be toxic to HepG2 cells expressing CYP2E1 by a mechanism involving oxidative stress and lipid peroxidation. Fatty Acids, Unsaturated 0-27 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 113-119 10718635-1 2000 Ethanol and polyunsaturated fatty acids such as arachidonic acid were shown to be toxic and cause apoptosis in HepG2 cells which express CYP2E1 but not in control HepG2 cell lines. Fatty Acids, Unsaturated 12-39 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 137-143 10718635-11 2000 These results extend previous observations found with HepG2 cells expressing CYP2E1 to intact hepatocytes and suggest that release of cytochrome c and activation of caspase 3 play a role in the overall pathway by which CYP2E1 contributes towards the hepatotoxic actions of ethanol and polyunsaturated fatty acids. Fatty Acids, Unsaturated 285-312 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 219-225 9660301-8 1998 It is proposed that elevated production of reactive oxygen intermediates by cells expressing CYP2E1 can cause lipid peroxidation, which subsequently promotes apoptosis and cell toxicity when the cells are enriched with polyunsaturated fatty acids such as arachidonic acid. Fatty Acids, Unsaturated 219-246 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 93-99 9699015-4 1998 In a similar manner, addition of a polyunsaturated fatty acid such as arachidonic acid produced toxicity to the cells expressing CYP2E1 but not the control cells. Fatty Acids, Unsaturated 35-61 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 129-135 9169410-9 1997 It is proposed that elevated production of reactive oxygen intermediates by cells expressing CYP2E1 can cause lipid peroxidation, which subsequently promotes apoptosis and cell toxicity when the cells are enriched with polyunsaturated fatty acids such as arachidonic acid. Fatty Acids, Unsaturated 219-246 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 93-99 8123200-2 1993 By varying the dietary fatty acid composition we showed that the pathology was worsened by increasing linoleic acid or polyunsaturated fatty acids (PUFAs) in the diet where cytochrome P4502E1 (CYP2E1) was increased posttranslationally by high BAL. Fatty Acids, Unsaturated 119-146 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 173-191 8123200-2 1993 By varying the dietary fatty acid composition we showed that the pathology was worsened by increasing linoleic acid or polyunsaturated fatty acids (PUFAs) in the diet where cytochrome P4502E1 (CYP2E1) was increased posttranslationally by high BAL. Fatty Acids, Unsaturated 119-146 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 193-199 8123200-2 1993 By varying the dietary fatty acid composition we showed that the pathology was worsened by increasing linoleic acid or polyunsaturated fatty acids (PUFAs) in the diet where cytochrome P4502E1 (CYP2E1) was increased posttranslationally by high BAL. Fatty Acids, Unsaturated 148-153 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 173-191 8123200-2 1993 By varying the dietary fatty acid composition we showed that the pathology was worsened by increasing linoleic acid or polyunsaturated fatty acids (PUFAs) in the diet where cytochrome P4502E1 (CYP2E1) was increased posttranslationally by high BAL. Fatty Acids, Unsaturated 148-153 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 193-199