PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2495173-3 1989 For several samples of urinary bladder epithelium, prostatic epithelium, colonic mucosa, and peripheral lung tissue, an arachidonic acid-dependent, microsomal-catalyzed activation of benzidine was observed; and the activity could be inhibited appreciably by indomethacin, a known inhibitor of PHS. benzidine 183-192 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 293-296 2495173-6 1989 Purified PHS catalyzed the activation of benzidine much greater than 2-naphthylamine, 2-amino-6-methyldipyrido[1,2-alpha:3",2"-d]imidazole greater than 4-aminobiphenyl greater than 2-amino-3-methylimidazo[4,5-f]quinoline greater than 3-amino-1-methyl-5H-pyrido[4,3-b] indole. benzidine 41-50 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 9-12 6418878-0 1983 Prostaglandin H synthase-catalyzed activation of benzidine: a model to assess pharmacologic intervention of the initiation of chemical carcinogenesis. benzidine 49-58 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 0-24 6418878-3 1983 The procarcinogen benzidine was used to identify sites at which microsomal PHS-catalyzed binding might be inhibited by pharmacologic agents. benzidine 18-27 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 75-78 6418878-6 1983 This study provides the first demonstration of inhibition of PHS-activated benzidine binding by propylthiouracil, methimazole, MK447, vitamin C and phenidone. benzidine 75-84 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 61-64 6418878-7 1983 The agents tested identified the following sites at which PHS-catalyzed binding of benzidine can be prevented: 1) inhibition of generation of the peroxide cosubstrate for benzidine oxidation; 2) inhibition of prostaglandin hydroperoxidase; 3) reduction of oxidized intermediate(s) to the parent compound; and 4) conjugation of the activated intermediate(s). benzidine 83-92 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 58-61 6418878-7 1983 The agents tested identified the following sites at which PHS-catalyzed binding of benzidine can be prevented: 1) inhibition of generation of the peroxide cosubstrate for benzidine oxidation; 2) inhibition of prostaglandin hydroperoxidase; 3) reduction of oxidized intermediate(s) to the parent compound; and 4) conjugation of the activated intermediate(s). benzidine 171-180 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 58-61