PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16815818-2 2006 In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated. benzidine 186-195 linoleate 9S-lipoxygenase-4 Glycine max 138-150 10910470-2 2000 "Shuttle Oxidant" effect of lipoxygenase-generated radical of chlorpromazine and related phenothiazines on the oxidation of benzidine and other xenobiotics. benzidine 124-133 linoleate 9S-lipoxygenase-4 Glycine max 28-40 10910470-5 2000 To evaluate the hypothesis, we investigated the metabolic interaction of two well-known substrates, chlorpromazine and benzidine, which have been shown to be oxidized by soybean lipoxygenase in the presence of hydrogen peroxide. benzidine 119-128 linoleate 9S-lipoxygenase-4 Glycine max 178-190 10910470-6 2000 The evidence presented here clearly indicates that the chlorpromazine cation radical generated by the lipoxygenase triggers a rapid oxidation of benzidine to benzidine diimine. benzidine 145-154 linoleate 9S-lipoxygenase-4 Glycine max 102-114 10910470-12 2000 Preliminary data suggest that purified human term placental lipoxygenase also displays a similar stimulatory response in the benzidine oxidation in the presence of chlorpromazine. benzidine 125-134 linoleate 9S-lipoxygenase-4 Glycine max 60-72