PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29463068-0	2018	Benzidine Induces Epithelial-Mesenchymal Transition of Human Bladder Cancer Cells through Activation of ERK5 Pathway.	benzidine	0-9	mitogen-activated protein kinase 7	Homo sapiens	104-108	
29463068-10	2018	Moreover, Benzidine-induced EMT and ERK5 activation were completely suppressed by XMD8-92 and siRNAs specific to ERK5.	benzidine	10-19	mitogen-activated protein kinase 7	Homo sapiens	36-40	
29463068-10	2018	Moreover, Benzidine-induced EMT and ERK5 activation were completely suppressed by XMD8-92 and siRNAs specific to ERK5.	benzidine	10-19	mitogen-activated protein kinase 7	Homo sapiens	113-117	
29463068-12	2018	Collectively, our findings revealed that ERK5-mediated EMT was critically involved in benzidine-correlated BC progression, indicating the therapeutic significance of ERK5 in benzidine-related BC.	benzidine	86-95	mitogen-activated protein kinase 7	Homo sapiens	41-45	
29463068-12	2018	Collectively, our findings revealed that ERK5-mediated EMT was critically involved in benzidine-correlated BC progression, indicating the therapeutic significance of ERK5 in benzidine-related BC.	benzidine	86-95	mitogen-activated protein kinase 7	Homo sapiens	166-170	
29463068-12	2018	Collectively, our findings revealed that ERK5-mediated EMT was critically involved in benzidine-correlated BC progression, indicating the therapeutic significance of ERK5 in benzidine-related BC.	benzidine	174-183	mitogen-activated protein kinase 7	Homo sapiens	41-45	
29463068-12	2018	Collectively, our findings revealed that ERK5-mediated EMT was critically involved in benzidine-correlated BC progression, indicating the therapeutic significance of ERK5 in benzidine-related BC.	benzidine	174-183	mitogen-activated protein kinase 7	Homo sapiens	166-170	
29463068-3	2018	The underlying molecular mechanisms of mitogen-activated protein kinase (MAPK) pathway, especially extracellular regulated protein kinases 5 (ERK5), in regulating benzidine-induced EMT remains unclarified.	benzidine	163-172	mitogen-activated protein kinase 7	Homo sapiens	99-140	
29463068-3	2018	The underlying molecular mechanisms of mitogen-activated protein kinase (MAPK) pathway, especially extracellular regulated protein kinases 5 (ERK5), in regulating benzidine-induced EMT remains unclarified.	benzidine	163-172	mitogen-activated protein kinase 7	Homo sapiens	142-146	
29463068-9	2018	Meanwhile, benzidine administration led to activation of ERK5 and activator protein 1 (AP-1) proteins, without effective stimulation of the Jun N-terminal kinase (JNK) or p38 pathways.	benzidine	11-20	mitogen-activated protein kinase 7	Homo sapiens	57-61	
28259934-0	2017	Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells.	benzidine	18-27	mitogen-activated protein kinase 7	Homo sapiens	89-93	
28259934-4	2017	The role of extracellular regulated protein kinase 5 (ERK5) in benzidine-meditated bladder cancer development has not been explored.	benzidine	63-72	mitogen-activated protein kinase 7	Homo sapiens	12-52	
28259934-4	2017	The role of extracellular regulated protein kinase 5 (ERK5) in benzidine-meditated bladder cancer development has not been explored.	benzidine	63-72	mitogen-activated protein kinase 7	Homo sapiens	54-58	
28259934-5	2017	In the present study, we explored the role of ERK5/AP-1 pathway in benzidine-induced EMT in human normal urothelial cells and the intervention effect of curcumin on bezidine-induced EMT.	benzidine	67-76	mitogen-activated protein kinase 7	Homo sapiens	46-50	
28259934-8	2017	Specific ERK5 inhibitor, XMD8-92 was applied to determine the role of ERK5 in benzidine-induced EMT.	benzidine	78-87	mitogen-activated protein kinase 7	Homo sapiens	70-74	
28259934-10	2017	Furthermore, curcumin effectively attenuated benzidine-induced urocystic EMT by suppressing ERK5/AP-1 pathway.	benzidine	45-54	mitogen-activated protein kinase 7	Homo sapiens	92-96	
28259934-11	2017	In conclusion, the present study revealed the positive role of ERK5/AP-1 in benzidine-provoked urocystic EMT and the curcumin promising use in bladder cancer prevention and intervention via ERK5/AP-1 pathway.	benzidine	76-85	mitogen-activated protein kinase 7	Homo sapiens	63-67