PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18923065-1	2009	The benzylindazole derivative 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1) is an allosteric stimulator of soluble guanylate cyclase (sGC) that sensitizes the enzyme to the gaseous ligands carbon monoxide (CO) and nitric oxide (NO).	3-Benzyl-1H-indazole	4-18	RNA binding motif single stranded interacting protein 1	Homo sapiens	79-83	
19089334-4	2009	The benzylindazole compound YC-1 was the first sGC stimulator to be identified; this compound formed a lead structure for the development of optimized sGC stimulators with improved potency and specificity for sGC, including CFM-1571, BAY 41-2272, BAY 41-8543, and BAY 63-2521.	3-Benzyl-1H-indazole	4-18	RNA binding motif single stranded interacting protein 1	Homo sapiens	28-32	
16331986-4	2005	Nitrosoalkanes activate sGC 2-6-fold and synergize with YC-1, a synthetic benzylindazole derivative, to activate the enzyme 11-47-fold.	3-Benzyl-1H-indazole	74-88	RNA binding motif single stranded interacting protein 1	Homo sapiens	56-60	
17587571-1	2007	Soluble guanylate cyclase (sGC) is activated by the known benzylindazole derivative YC-1 [1-benzyl-3-(5"-hydroxymethyl-2"-furyl)-indazole].	3-Benzyl-1H-indazole	58-72	RNA binding motif single stranded interacting protein 1	Homo sapiens	84-88	
15845095-3	2005	YC-1, which is a benzylindazole derivative, greatly potentiated the response of soluble guanylate cyclase to NO (up to several hundreds fold).	3-Benzyl-1H-indazole	17-31	RNA binding motif single stranded interacting protein 1	Homo sapiens	0-4	
12540839-1	2003	The benzylindazole compound YC-1 has been shown to activate soluble guanylate cyclase by increasing the sensitivity toward NO and CO.	3-Benzyl-1H-indazole	4-18	RNA binding motif single stranded interacting protein 1	Homo sapiens	28-32	
15148243-8	2004	4 The in vitro and in vivo vasorelaxant activities of CORM-3 were further enhanced in the presence of YC-1, a benzylindazole derivative which is known to sensitize guanylate cyclase to activation by CO. Interestingly, inhibiting nitric oxide production or removing the endothelium significantly decreased vasodilatation by CORM-3, suggesting that factors produced by the endothelium influence CORM-3 vascular activities.	3-Benzyl-1H-indazole	110-124	RNA binding motif single stranded interacting protein 1	Homo sapiens	102-106	
10451364-1	1999	Previous work has proved that the enzyme-soluble guanylate cyclase, GC, is activated several 100-fold by the combination of carbon monoxide plus a benzylindazole derivative called YC-1.	3-Benzyl-1H-indazole	147-161	RNA binding motif single stranded interacting protein 1	Homo sapiens	180-184	
9855623-2	1998	YC-1, a benzylindazole derivative, was shown to activate sGC in intact platelets, resulting in inhibition of platelet aggregation.	3-Benzyl-1H-indazole	8-22	RNA binding motif single stranded interacting protein 1	Homo sapiens	0-4	
8640334-2	1995	Our previous study demonstrated that YC-1, a derivative of benzylindazole, is a novel activator of soluble guanylate cyclase (sGC) in rabbit platelets.	3-Benzyl-1H-indazole	59-73	RNA binding motif single stranded interacting protein 1	Homo sapiens	37-41