PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10487855-0	1999	Elastin calcification and its prevention with aluminum chloride pretreatment.	Aluminum Chloride	46-63	elastin	Rattus norvegicus	0-7	
11733347-0	2001	Aluminum chloride pretreatment of elastin inhibits elastolysis by matrix metalloproteinases and leads to inhibition of elastin-oriented calcification.	Aluminum Chloride	0-17	elastin	Rattus norvegicus	34-41	
11733347-0	2001	Aluminum chloride pretreatment of elastin inhibits elastolysis by matrix metalloproteinases and leads to inhibition of elastin-oriented calcification.	Aluminum Chloride	0-17	elastin	Rattus norvegicus	119-126	
11733347-2	2001	We have previously shown that purified elastin when subdermally implanted in rats undergoes severe calcification and aluminum chloride (AlCl(3)) pretreatment of elastin inhibits calcification.	Aluminum Chloride	117-134	elastin	Rattus norvegicus	39-46	
11733347-2	2001	We have previously shown that purified elastin when subdermally implanted in rats undergoes severe calcification and aluminum chloride (AlCl(3)) pretreatment of elastin inhibits calcification.	Aluminum Chloride	117-134	elastin	Rattus norvegicus	161-168	
11733347-2	2001	We have previously shown that purified elastin when subdermally implanted in rats undergoes severe calcification and aluminum chloride (AlCl(3)) pretreatment of elastin inhibits calcification.	Aluminum Chloride	136-143	elastin	Rattus norvegicus	161-168	
11733347-3	2001	In the present study we investigated whether matrix metalloproteinase (MMP) binding to elastin and elastin degradation is prevented by AlCl(3) pretreatment.	Aluminum Chloride	135-142	elastin	Rattus norvegicus	87-94	
11733347-3	2001	In the present study we investigated whether matrix metalloproteinase (MMP) binding to elastin and elastin degradation is prevented by AlCl(3) pretreatment.	Aluminum Chloride	135-142	elastin	Rattus norvegicus	99-106	
11733347-4	2001	Subdermal implantation of AlCl(3)-pretreated elastin showed significantly lower MMP-9 and MMP-2 activity surrounding the implant as compared to the control implants.	Aluminum Chloride	26-33	elastin	Rattus norvegicus	45-52	
11733347-5	2001	AlCl(3) pretreatment also significantly inhibited elastin implant calcification at the seven-day implant period (AlCl(3)-pretreated 4.07 +/- 1.27, control 23.82 +/- 2.24 microg/mg; p<0.0001).	Aluminum Chloride	0-7	elastin	Rattus norvegicus	50-57	
11733347-5	2001	AlCl(3) pretreatment also significantly inhibited elastin implant calcification at the seven-day implant period (AlCl(3)-pretreated 4.07 +/- 1.27, control 23.82 +/- 2.24 microg/mg; p<0.0001).	Aluminum Chloride	113-120	elastin	Rattus norvegicus	50-57	
11733347-6	2001	Moreover, elastin gel zymography studies showed that gel pretreatment with AlCl(3) inhibited elastolysis by MMP-9.	Aluminum Chloride	75-82	elastin	Rattus norvegicus	10-17	
11733347-8	2001	AlCl(3) pretreatment also significantly inhibited calcification of elastin in this model.	Aluminum Chloride	0-7	elastin	Rattus norvegicus	67-74	
10487855-11	1999	Thus, it is concluded that purified elastin calcifies in rat subdermal implants, and that the AlCl(3)-pretreated elastin completely resists calcification due to irreversible aluminum ion binding and subsequent structural alterations caused by AlCl(3).	Aluminum Chloride	94-101	elastin	Rattus norvegicus	113-120	
10487855-11	1999	Thus, it is concluded that purified elastin calcifies in rat subdermal implants, and that the AlCl(3)-pretreated elastin completely resists calcification due to irreversible aluminum ion binding and subsequent structural alterations caused by AlCl(3).	Aluminum Chloride	243-250	elastin	Rattus norvegicus	113-120	
10487855-5	1999	We investigated the time course of calcification, the effect of glutaraldehyde crosslinking on calcification, and mechanisms of inhibition of elastin calcification by pretreatment with aluminum chloride (AlCl(3)).	Aluminum Chloride	185-202	elastin	Rattus norvegicus	142-149	
10487855-5	1999	We investigated the time course of calcification, the effect of glutaraldehyde crosslinking on calcification, and mechanisms of inhibition of elastin calcification by pretreatment with aluminum chloride (AlCl(3)).	Aluminum Chloride	204-211	elastin	Rattus norvegicus	142-149	
10487855-8	1999	Our results further demonstrated that AlCl(3) pretreatment of elastin led to complete inhibition of elastin calcification using 21-day rat subdermal implants, irrespective of glutaraldehyde crosslinking (Ca(2+) = 0.73-2.15 microgram/mg for AlCl(3) pretreated elastin versus 89.73 +/- 9.84 for untreated elastin).	Aluminum Chloride	38-45	elastin	Rattus norvegicus	62-69	
10487855-8	1999	Our results further demonstrated that AlCl(3) pretreatment of elastin led to complete inhibition of elastin calcification using 21-day rat subdermal implants, irrespective of glutaraldehyde crosslinking (Ca(2+) = 0.73-2.15 microgram/mg for AlCl(3) pretreated elastin versus 89.73 +/- 9.84 for untreated elastin).	Aluminum Chloride	38-45	elastin	Rattus norvegicus	100-107	
10487855-8	1999	Our results further demonstrated that AlCl(3) pretreatment of elastin led to complete inhibition of elastin calcification using 21-day rat subdermal implants, irrespective of glutaraldehyde crosslinking (Ca(2+) = 0.73-2.15 microgram/mg for AlCl(3) pretreated elastin versus 89.73 +/- 9.84 for untreated elastin).	Aluminum Chloride	38-45	elastin	Rattus norvegicus	100-107	
10487855-8	1999	Our results further demonstrated that AlCl(3) pretreatment of elastin led to complete inhibition of elastin calcification using 21-day rat subdermal implants, irrespective of glutaraldehyde crosslinking (Ca(2+) = 0.73-2.15 microgram/mg for AlCl(3) pretreated elastin versus 89.73 +/- 9.84 for untreated elastin).	Aluminum Chloride	38-45	elastin	Rattus norvegicus	100-107	
10487855-8	1999	Our results further demonstrated that AlCl(3) pretreatment of elastin led to complete inhibition of elastin calcification using 21-day rat subdermal implants, irrespective of glutaraldehyde crosslinking (Ca(2+) = 0.73-2.15 microgram/mg for AlCl(3) pretreated elastin versus 89.73 +/- 9.84 for untreated elastin).	Aluminum Chloride	240-247	elastin	Rattus norvegicus	62-69	
10487855-9	1999	The AlCl(3) pretreatment caused irreversible binding of aluminum ions to elastin, as assessed by atomic emission spectroscopy.	Aluminum Chloride	4-11	elastin	Rattus norvegicus	73-80