PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29704576-0	2018	Bone impairment caused by AlCl3 is associated with activation of the JNK apoptotic pathway mediated by oxidative stress.	Aluminum Chloride	26-31	mitogen-activated protein kinase 8	Rattus norvegicus	69-72	
29704576-9	2018	In addition, AlCl3 caused oxidative stress, up-regulated expression of c-Jun and pro-apoptotic factors with increased p-JNK/JNK ratio and down-regulated expression of anti-apoptotic factor Bcl-2 in bone.	Aluminum Chloride	13-18	mitogen-activated protein kinase 8	Rattus norvegicus	120-123	
29704576-9	2018	In addition, AlCl3 caused oxidative stress, up-regulated expression of c-Jun and pro-apoptotic factors with increased p-JNK/JNK ratio and down-regulated expression of anti-apoptotic factor Bcl-2 in bone.	Aluminum Chloride	13-18	mitogen-activated protein kinase 8	Rattus norvegicus	124-127	
29704576-10	2018	Taken together, these results indicate that bone impairment caused by AlCl3 is associated with activation of the oxidative stress-mediated JNK apoptotic pathway.	Aluminum Chloride	70-75	mitogen-activated protein kinase 8	Rattus norvegicus	139-142	
32007895-0	2020	Aluminum trichloride caused hippocampal neural cells death and subsequent depression-like behavior in rats via the activation of IL-1beta/JNK signaling pathway.	Aluminum Chloride	0-20	mitogen-activated protein kinase 8	Rattus norvegicus	138-141	
32007895-10	2020	Finally, AlCl3 increased the proteins level of IL-1beta, IL-1RI, IL-1RAcP, JNK and p-JNK, indicating that AlCl3 activated IL-1beta/JNK signaling pathway.	Aluminum Chloride	9-14	mitogen-activated protein kinase 8	Rattus norvegicus	75-78	
32007895-10	2020	Finally, AlCl3 increased the proteins level of IL-1beta, IL-1RI, IL-1RAcP, JNK and p-JNK, indicating that AlCl3 activated IL-1beta/JNK signaling pathway.	Aluminum Chloride	9-14	mitogen-activated protein kinase 8	Rattus norvegicus	85-88	
32007895-10	2020	Finally, AlCl3 increased the proteins level of IL-1beta, IL-1RI, IL-1RAcP, JNK and p-JNK, indicating that AlCl3 activated IL-1beta/JNK signaling pathway.	Aluminum Chloride	9-14	mitogen-activated protein kinase 8	Rattus norvegicus	85-88	
32007895-10	2020	Finally, AlCl3 increased the proteins level of IL-1beta, IL-1RI, IL-1RAcP, JNK and p-JNK, indicating that AlCl3 activated IL-1beta/JNK signaling pathway.	Aluminum Chloride	106-111	mitogen-activated protein kinase 8	Rattus norvegicus	75-78	
32007895-10	2020	Finally, AlCl3 increased the proteins level of IL-1beta, IL-1RI, IL-1RAcP, JNK and p-JNK, indicating that AlCl3 activated IL-1beta/JNK signaling pathway.	Aluminum Chloride	106-111	mitogen-activated protein kinase 8	Rattus norvegicus	85-88	
32007895-10	2020	Finally, AlCl3 increased the proteins level of IL-1beta, IL-1RI, IL-1RAcP, JNK and p-JNK, indicating that AlCl3 activated IL-1beta/JNK signaling pathway.	Aluminum Chloride	106-111	mitogen-activated protein kinase 8	Rattus norvegicus	85-88	
32007895-11	2020	However, the application of IL-1 receptor antagonist (IL-1Ra) inhibited the phosphorylation of JNK and the related genes expression of apoptosis and necroptosis caused by AlCl3.	Aluminum Chloride	171-176	mitogen-activated protein kinase 8	Rattus norvegicus	95-98	
32007895-12	2020	Thus, we concluded that AlCl3 induced hippocampal neural cells death and depression-like behavior in rats by activating IL-1beta/JNK signaling pathway.	Aluminum Chloride	24-29	mitogen-activated protein kinase 8	Rattus norvegicus	129-132