PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20813864-10 2010 Emetine-induced HIF-2alpha down-regulation was confirmed in three additional VHL-renal cancer cell lines, was insensitive to the prolyl hydroxylase inhibitor dimethyloxaloyl glycine, and did not require neural precursor cell expressed developmentally down-regulated-8, suggesting that emetine accesses a previously undescribed cullin-independent proteasome degradation pathway for HIF-2alpha. Emetine 0-7 CDK2 associated cullin domain 1 Homo sapiens 327-333