PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19527117-2 2009 In this study, an integrin alphavbeta3 and alphavbeta5 binding tripeptide, RGD (Arg-Gly-Asp), was conjugated with the surface of poly(ethylene glycol)-block-poly(D,L-lactide) (PEG-PLA) micelles. arginyl-glycyl-aspartic acid 80-91 integrin subunit alpha V Homo sapiens 18-38 20641284-6 2004 Several integrins, such as integrin alphavbeta3, have affinity for the arginine-glycine-aspartic acid (RGD) tripeptide motif, which is found in many ECM proteins. arginyl-glycyl-aspartic acid 71-101 integrin subunit alpha V Homo sapiens 27-47 20641381-5 2004 Several integrins, such as integrin alphavbeta3, have affinity for the arginine-glycine-aspartic acid (RGD) tripeptide motif, which is found in many ECM proteins. arginyl-glycyl-aspartic acid 71-101 integrin subunit alpha V Homo sapiens 27-47 20641687-4 2004 Several integrins, such as integrin alphavbeta3, have affinity for the arginine-glycine-aspartic acid (RGD) tripeptide motif, which is found in many ECM proteins. arginyl-glycyl-aspartic acid 71-101 integrin subunit alpha V Homo sapiens 27-47 20641375-5 2004 Several integrins, such as integrin alphavbeta3, have affinity for the arginine-glycine-aspartic acid (RGD) tripeptide motif, which is found in many ECM proteins. arginyl-glycyl-aspartic acid 71-101 integrin subunit alpha V Homo sapiens 27-47 20641437-5 2004 Several integrins, such as integrin alphavbeta3, have affinity for the arginine-glycine-aspartic acid (RGD) tripeptide motif, which is found in many ECM proteins. arginyl-glycyl-aspartic acid 71-101 integrin subunit alpha V Homo sapiens 27-47 20641361-5 2004 Several integrins, such as integrin alphavbeta3, have affinity for the arginine-glycine-aspartic acid (RGD) tripeptide motif, which is found in many ECM proteins. arginyl-glycyl-aspartic acid 71-101 integrin subunit alpha V Homo sapiens 27-47 20641766-3 2004 Several integrins, such as integrin alphavbeta3, have affinity for the arginine-glycine-aspartic acid (RGD) tripeptide motif, which is found in many ECM proteins. arginyl-glycyl-aspartic acid 71-101 integrin subunit alpha V Homo sapiens 27-47 33803385-1 2021 Arg-Gly-Asp (RGD)-based cyclopentapeptides (cRGDs) have a high affinity towards integrin alphavbeta3 and alphavbeta5, which are overexpressed by many tumor cells. arginyl-glycyl-aspartic acid 0-11 integrin subunit alpha V Homo sapiens 80-100 20641240-5 2004 Several integrins, such as integrin alphavbeta3, have affinity for the arginine-glycine-aspartic acid (RGD) tripeptide motif, which is found in many ECM proteins. arginyl-glycyl-aspartic acid 71-101 integrin subunit alpha V Homo sapiens 27-47 18221059-5 2007 Integrin alpha (v)beta(3) is a glycoprotein membrane receptor which recognizes ECM proteins expressing an arginine-glycine-aspartic acid (RGD) peptide sequence. arginyl-glycyl-aspartic acid 106-136 integrin subunit alpha V Homo sapiens 0-15 15530369-1 2004 Integrin alpha(V)beta(3) binds to extracellular matrix proteins through the tripeptide Arg-Gly-Asp (RGD), forming a shallow crevice rather than a deep binding pocket. arginyl-glycyl-aspartic acid 87-98 integrin subunit alpha V Homo sapiens 0-24 11433393-2 2001 On the other hand, most inhibitors of integrin alpha v beta 3 are peptide antagonists that include the Arg-Gly-Asp (RGD) motif. arginyl-glycyl-aspartic acid 103-114 integrin subunit alpha V Homo sapiens 38-61 33803385-1 2021 Arg-Gly-Asp (RGD)-based cyclopentapeptides (cRGDs) have a high affinity towards integrin alphavbeta3 and alphavbeta5, which are overexpressed by many tumor cells. arginyl-glycyl-aspartic acid 13-16 integrin subunit alpha V Homo sapiens 80-100 35480387-1 2022 An integrin alphaVbeta3-targeting linear RGD mimetic containing a small-molecule drug conjugate (SMDC) was synthesized by combining the antimitotic agent monomethyl auristatin E (MMAE), an enzymatically cleavable Val-Ala-PABC linker with a linear conjugable RGD mimetic. arginyl-glycyl-aspartic acid 41-44 integrin subunit alpha V Homo sapiens 3-23 34356543-1 2021 Integrin alphavbeta3 interacting with the short Arg-Gly-Asp (RGD) motif plays a critical role in the progression of several types of tumors. arginyl-glycyl-aspartic acid 48-59 integrin subunit alpha V Homo sapiens 0-20 34356543-1 2021 Integrin alphavbeta3 interacting with the short Arg-Gly-Asp (RGD) motif plays a critical role in the progression of several types of tumors. arginyl-glycyl-aspartic acid 61-64 integrin subunit alpha V Homo sapiens 0-20 32451087-0 2020 Radioiodinated bicyclic RGD peptide for imaging integrin alphavbeta3 in cancers. arginyl-glycyl-aspartic acid 24-35 integrin subunit alpha V Homo sapiens 48-68 35370207-4 2022 Ligands bearing 2-aminobenzimidazoyl and glycyl groups separated by a benzophenone spacer demonstrated more potent binding than did a linear Arg-Gly-Asp (RGD) tripeptide that represents the native integrin alphavbeta3 binding motif. arginyl-glycyl-aspartic acid 141-152 integrin subunit alpha V Homo sapiens 197-217 32612532-4 2020 Folic acid and arginine-glycine-aspartate (Arg-Gly-Asp, RGD) tripeptide sequence have a high affinity for folate receptor and integrin alpha v beta 3, respectively. arginyl-glycyl-aspartic acid 56-59 integrin subunit alpha V Homo sapiens 126-149 32612532-4 2020 Folic acid and arginine-glycine-aspartate (Arg-Gly-Asp, RGD) tripeptide sequence have a high affinity for folate receptor and integrin alpha v beta 3, respectively. arginyl-glycyl-aspartic acid 43-54 integrin subunit alpha V Homo sapiens 126-149 32688289-1 2020 PURPOSE: Integrin alphavbeta3, a member of the arginine-glycine-aspartate (RGD)-binding subfamily, is associated with tumor angiogenesis and metastasis. arginyl-glycyl-aspartic acid 75-78 integrin subunit alpha V Homo sapiens 9-29 32655786-3 2020 Arg-Gly-Asp (RGD) is a peptide targeting integrin alphavbeta3, which is highly expressed during tumor angiogenesis. arginyl-glycyl-aspartic acid 0-11 integrin subunit alpha V Homo sapiens 41-61 32655786-3 2020 Arg-Gly-Asp (RGD) is a peptide targeting integrin alphavbeta3, which is highly expressed during tumor angiogenesis. arginyl-glycyl-aspartic acid 13-16 integrin subunit alpha V Homo sapiens 41-61 31243977-5 2019 The latter is composed of the Arg-Gly-Asp peptide sequence cyclized via a diketopiperazine scaffold and is characterized by its high selectivity toward integrin alphavbeta3. arginyl-glycyl-aspartic acid 30-49 integrin subunit alpha V Homo sapiens 152-172 31642677-1 2019 The cyclic Arg-Gly-Asp(cRGD) peptides are widely used as tumor-targeting ligands due to their specific binding ability to integrin alphavbeta3 that is overexpressed on the surface of various cancer cells and the epithelial cells of new blood vessels within tumor tissue. arginyl-glycyl-aspartic acid 4-22 integrin subunit alpha V Homo sapiens 122-142 31540828-2 2019 Octreotate (TATE) and Arg-Gly-Asp (RGD) peptides target somatostatin receptor 2 (sstr2) and integrin alphavbeta3, respectively. arginyl-glycyl-aspartic acid 22-33 integrin subunit alpha V Homo sapiens 92-112 31540828-2 2019 Octreotate (TATE) and Arg-Gly-Asp (RGD) peptides target somatostatin receptor 2 (sstr2) and integrin alphavbeta3, respectively. arginyl-glycyl-aspartic acid 35-38 integrin subunit alpha V Homo sapiens 92-112 25647279-0 2015 A fluorescent Arg-Gly-Asp (RGD) peptide-naphthalenediimide (NDI) conjugate for imaging integrin alpha(v)beta(3) in vitro. arginyl-glycyl-aspartic acid 14-25 integrin subunit alpha V Homo sapiens 87-110 26957261-1 2016 OBJECTIVE: To design a new Arg-Gly-Asp (RGD) peptide that can specifically bind integrin alphavbeta3 and evaluate the possibility of using 131I-labeled peptide for imaging alphavbeta3-positive tumors. arginyl-glycyl-aspartic acid 27-38 integrin subunit alpha V Homo sapiens 80-100 30811704-3 2019 Inhibitors of integrin alphav beta3 are interesting anticancer agents but their molecular mechanisms are still unclear: Peptides and peptidomimetics characterized by the Arg-Gly-Asp (RGD) or isoAsp-Gly-Arg (isoDGR) binding motifs have shown controversial agonist/antagonist effects. arginyl-glycyl-aspartic acid 170-181 integrin subunit alpha V Homo sapiens 14-35 30578136-2 2019 Arg-Gly-Asp (RGD) and GE11 peptides specifically target integrin alphaVbeta3 and EGFR, respectively. arginyl-glycyl-aspartic acid 0-11 integrin subunit alpha V Homo sapiens 56-76 28363829-5 2017 A ligand of integrin alphav-beta3, (cyclopentapeptide containing Arginyl-Glycyl-Aspartic acid motif, RGD), was used to mimic integrin signaling. arginyl-glycyl-aspartic acid 65-93 integrin subunit alpha V Homo sapiens 12-33 25349221-1 2014 UNLABELLED: RGD (arginylglycylaspartic acid)-based imaging tracers allow specific imaging of integrin alphavbeta3 expression, proteins overexpressed during angiogenesis; however, few studies have investigated the potential of these tracers to monitor responses of antiangiogenic or radiation therapy. arginyl-glycyl-aspartic acid 17-44 integrin subunit alpha V Homo sapiens 93-113 23708872-1 2013 INTRODUCTION: Radiolabeled Arg-Gly-Asp (RGD) and bombesin (BBN) heterodimers have been investigated for dual targeting of tumor integrin alphavbeta3 receptors and gastrin-releasing peptide receptors. arginyl-glycyl-aspartic acid 27-38 integrin subunit alpha V Homo sapiens 128-148 24212468-2 2014 Arg-Gly-Asp (RGD) and Asn-Gly-Arg (NGR) were combined in the targeting vector so as to allow binding, on the surface of tumor cells, to integrin alphavbeta3 and aminopeptidase N (CD13), respectively. arginyl-glycyl-aspartic acid 0-11 integrin subunit alpha V Homo sapiens 136-156 21547159-4 2011 The peptide ligands containing the arginine-glycine-aspartic acid (RGD), which displays a strong binding affinity and selectivity to integrins, particularly to integrin alphavbeta3, have been developed to conjugate with various conventional chemotherapeutic agents, such as small molecules, peptides and proteins, and nanoparticle-carried drugs for integtrin targeted therapeutic studies. arginyl-glycyl-aspartic acid 35-65 integrin subunit alpha V Homo sapiens 160-180 22248086-2 2012 However, the apoptosis induction capacity of mda-7/IL-24 was low and directly correlated with the adhesion to tumor cells.Cell adhesion molecule integrin alpha(v)beta(3) expressed on the surface of several types of solid tumor cells, and they bind to arginine-glycine-aspartic acid (RGD) which enhanced the adhesion to tumor cells. arginyl-glycyl-aspartic acid 251-281 integrin subunit alpha V Homo sapiens 145-169 21136958-4 2009 AS1411 aptamer, which targets nucleolin, was labeled by Cy3 (Cy3-AS1411) and arginine-glycine-aspartic acid (RGD) peptide, which targets integrin alpha(v) beta(3) , was conjugated with quantum dot (525 nm, Qd) Qd arginine-glycine-aspartic acid (Qd-RGD). arginyl-glycyl-aspartic acid 77-107 integrin subunit alpha V Homo sapiens 137-162 21136958-4 2009 AS1411 aptamer, which targets nucleolin, was labeled by Cy3 (Cy3-AS1411) and arginine-glycine-aspartic acid (RGD) peptide, which targets integrin alpha(v) beta(3) , was conjugated with quantum dot (525 nm, Qd) Qd arginine-glycine-aspartic acid (Qd-RGD). arginyl-glycyl-aspartic acid 213-243 integrin subunit alpha V Homo sapiens 137-162