PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21115820-0	2010	Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells.	phosphoinositide-3,4-bisphosphate	20-29	profilin 1	Homo sapiens	0-9	
25613364-2	2015	Profilin1, an actin and phosphoinositide binding protein, is downregulated in several adenocarcinomas and it is been shown that its depletion enhances invasiveness and motility of breast cancer cells by increasing PI(3,4)P2 levels at the leading edge.	phosphoinositide-3,4-bisphosphate	214-223	profilin 1	Homo sapiens	0-9	
25613364-6	2015	We found that loss of profilin1 expression increases the levels of PI(3,4)P2 at the invadopodium and as a result, enhances recruitment of the interacting adaptor Tks5.	phosphoinositide-3,4-bisphosphate	67-76	profilin 1	Homo sapiens	22-31	
25613364-8	2015	Our results indicate that profilin1 acts as a molecular regulator of the levels of PI(3,4)P2 and Tks5 recruitment in invadopodia to control the invasion efficiency of invadopodia.	phosphoinositide-3,4-bisphosphate	83-92	profilin 1	Homo sapiens	26-35