PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26022180-5	2015	Signaling through PI(3,4)P2 can be negatively regulated by inositol polyphosphate 4-phosphatases (INPP4A and INPP4B), which selectively degrade PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	18-27	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	109-115	
34035258-1	2021	INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer.	phosphoinositide-3,4-bisphosphate	51-60	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	0-6	
34035258-5	2021	We used integrated proteomics, transcriptomics and imaging to demonstrate INPP4B localized to late endosomes via interaction with Rab7, which increased endosomal PI3Kalpha-dependent PI(3,4)P2 to PI(3)P conversion, late endosome/lysosome number and cargo trafficking, resulting in enhanced GSK3beta lysosomal degradation and activation of Wnt/beta-catenin signaling.	phosphoinositide-3,4-bisphosphate	182-191	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	74-80	
34035258-7	2021	Therefore, INPP4B facilitates PI3Kalpha crosstalk with Wnt signaling in ER+ breast cancer via PI(3,4)P2 to PI(3)P conversion on late endosomes, suggesting these tumors may be targeted with combined PI3K and Wnt/beta-catenin therapies.	phosphoinositide-3,4-bisphosphate	94-103	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	11-17	
29343273-9	2018	The mass of PI (3,4) P2 and PI (3) P was analyzed by ELISA upon INPP4B overexpression.	phosphoinositide-3,4-bisphosphate	12-23	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	64-70	
28196852-0	2017	INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC.	phosphoinositide-3,4-bisphosphate	30-39	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	0-6	
28196852-3	2017	Inositol polyphosphate-4-phosphatase type II (INPP4B) catalyzes the removal of the 4"-phosphate of phosphatidylinositol-(3, 4)-bisphosphate (PI-3,4-P2), creating phosphatidylinositol-3-phosphate.	phosphoinositide-3,4-bisphosphate	141-150	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	46-52	
28196852-5	2017	If PI-3,4-P2 is a positive effector, INPP4B would be a negative regulator of PI3K signaling, and there is some evidence to support this.	phosphoinositide-3,4-bisphosphate	3-12	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	37-43	
28196852-8	2017	In summary, the current investigation of INPP4B in PTEN-null TNBC suggests new mechanistic insight and the potential for targeted therapy for this aggressive subset of breast cancer.Implications: These data support a model where PI-3,4-P2 is inhibitory toward PI3K, revealing a novel feedback mechanism under conditions of excessive signaling, and potentially an indication for PI3K-beta isoform-specific inhibitors in PTEN-null TNBC that have lost INPP4B expression.	phosphoinositide-3,4-bisphosphate	229-238	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	41-47	
28196852-8	2017	In summary, the current investigation of INPP4B in PTEN-null TNBC suggests new mechanistic insight and the potential for targeted therapy for this aggressive subset of breast cancer.Implications: These data support a model where PI-3,4-P2 is inhibitory toward PI3K, revealing a novel feedback mechanism under conditions of excessive signaling, and potentially an indication for PI3K-beta isoform-specific inhibitors in PTEN-null TNBC that have lost INPP4B expression.	phosphoinositide-3,4-bisphosphate	229-238	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	449-455	
26022180-5	2015	Signaling through PI(3,4)P2 can be negatively regulated by inositol polyphosphate 4-phosphatases (INPP4A and INPP4B), which selectively degrade PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	144-153	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	109-115	
24591580-5	2014	INPP4B, which dephosphorylates PI(3,4)P2 to PI(3)P, was also found to be essential for macropinocytosis.	phosphoinositide-3,4-bisphosphate	31-40	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	0-6	
24091101-6	2014	This could be linked to the relative importance of PI(3,4)P2 (a product of SHIP2 phosphatase activity) which is also controlled by the PI 4-phosphatase and tumor suppressor INPP4B.	phosphoinositide-3,4-bisphosphate	51-60	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	173-179	
22403078-9	2012	The inositol polyphosphate 4-phosphatases, INPP4A and INPP4B degrade PtdIns(3,4)P(2) to PtdIns(3)P and regulate neuroexcitatory cell death, or act as a tumor suppressor in breast cancer respectively.	phosphoinositide-3,4-bisphosphate	69-81	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	54-60