PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11468938-0 2001 A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide. Thiotepa 115-123 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-63 19616568-10 2009 This was further confirmed by significant inhibition of primaquine hemotoxicity by the selective CYP inhibitors, namely thiotepa (CYP2B6), fluoxetine (CYP2D6) and troleandomycin (CYP3A4). Thiotepa 120-128 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 97-100 12107550-0 2002 Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA. Thiotepa 86-94 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 12107550-1 2002 PURPOSE: To establish the cytochrome P450 (CYP) isozymes involved in the metabolism of the alkylating agent, thiotepa, to the pharmacologically active metabolite, TEPA. Thiotepa 109-117 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-41 12107550-1 2002 PURPOSE: To establish the cytochrome P450 (CYP) isozymes involved in the metabolism of the alkylating agent, thiotepa, to the pharmacologically active metabolite, TEPA. Thiotepa 109-117 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 43-46 12107550-10 2002 There is a potential for CYP-mediated drug interactions with thiotepa. Thiotepa 61-69 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 25-28 12107550-11 2002 Pharmacokinetic variability of thiotepa may be related to expression of hepatic CYP isozymes. Thiotepa 31-39 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-83 21573617-0 1993 Activation of thio-tepa cytotoxicity toward human breast-cancer cells by hepatic cytochrome-p450. Thiotepa 14-23 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 81-96 2504483-4 1989 Thiotepa was shown to be metabolized under these conditions in a NADPH- and O2-dependent reaction that was catalyzed by one or more microsomal cytochrome P-450 enzymes that were present in the S-9 fraction. Thiotepa 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 143-159 2504483-9 1989 These findings establish that the cytotoxic effects of thiotepa are oxygen dependent and may involve, at least in part, metabolic processes catalyzed by cytochrome P-450 enzymes. Thiotepa 55-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 153-169