PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21573617-0	1993	Activation of thio-tepa cytotoxicity toward human breast-cancer cells by hepatic cytochrome-p450.	Thiotepa	14-23	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-96	
11468938-0	2001	A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide.	Thiotepa	115-123	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	48-63	
19616568-10	2009	This was further confirmed by significant inhibition of primaquine hemotoxicity by the selective CYP inhibitors, namely thiotepa (CYP2B6), fluoxetine (CYP2D6) and troleandomycin (CYP3A4).	Thiotepa	120-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	97-100	
12107550-0	2002	Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA.	Thiotepa	86-94	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15	
12107550-1	2002	PURPOSE: To establish the cytochrome P450 (CYP) isozymes involved in the metabolism of the alkylating agent, thiotepa, to the pharmacologically active metabolite, TEPA.	Thiotepa	109-117	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-41	
12107550-1	2002	PURPOSE: To establish the cytochrome P450 (CYP) isozymes involved in the metabolism of the alkylating agent, thiotepa, to the pharmacologically active metabolite, TEPA.	Thiotepa	109-117	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-46	
12107550-10	2002	There is a potential for CYP-mediated drug interactions with thiotepa.	Thiotepa	61-69	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	25-28	
12107550-11	2002	Pharmacokinetic variability of thiotepa may be related to expression of hepatic CYP isozymes.	Thiotepa	31-39	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	80-83	
2504483-4	1989	Thiotepa was shown to be metabolized under these conditions in a NADPH- and O2-dependent reaction that was catalyzed by one or more microsomal cytochrome P-450 enzymes that were present in the S-9 fraction.	Thiotepa	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	143-159	
2504483-9	1989	These findings establish that the cytotoxic effects of thiotepa are oxygen dependent and may involve, at least in part, metabolic processes catalyzed by cytochrome P-450 enzymes.	Thiotepa	55-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	153-169