PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28980850-0	2018	Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progression.	Rilmenidine	0-11	superoxide dismutase 1, soluble	Mus musculus	62-66	
28980850-6	2018	Treatment of these cells with rilmenidine, an anti-hypertensive agent and imidazoline-1 receptor agonist that induces autophagy, promoted autophagic clearance of mutant SOD1 and efficient mitophagy.	Rilmenidine	30-41	superoxide dismutase 1, soluble	Mus musculus	169-173	
28980850-7	2018	Rilmenidine administration to mutant SOD1G93A mice upregulated autophagy and mitophagy in spinal cord, leading to reduced soluble mutant SOD1 levels.	Rilmenidine	0-11	superoxide dismutase 1, soluble	Mus musculus	37-41	
28980850-7	2018	Rilmenidine administration to mutant SOD1G93A mice upregulated autophagy and mitophagy in spinal cord, leading to reduced soluble mutant SOD1 levels.	Rilmenidine	0-11	superoxide dismutase 1, soluble	Mus musculus	137-141	
28980850-8	2018	Importantly, rilmenidine increased autophagosome abundance in motor neurons of SOD1G93A mice, suggesting a direct action on target cells.	Rilmenidine	13-24	superoxide dismutase 1, soluble	Mus musculus	79-83	
28980850-9	2018	Despite robust induction of autophagy in vivo, rilmenidine worsened motor neuron degeneration and symptom progression in SOD1G93A mice.	Rilmenidine	47-58	superoxide dismutase 1, soluble	Mus musculus	121-125	
28980850-10	2018	These effects were associated with increased accumulation and aggregation of insoluble and misfolded SOD1 species outside the autophagy pathway, and severe mitochondrial depletion in motor neurons of rilmenidine-treated mice.	Rilmenidine	200-211	superoxide dismutase 1, soluble	Mus musculus	101-105