PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20816810-0	2010	Activation of phosphatidylinositol 3-kinase/Akt signaling pathway and endogenous nitric oxide are needed for the antiarrhythmic effect of centrally administered rilmenidine.	Rilmenidine	161-172	AKT serine/threonine kinase 1	Rattus norvegicus	44-47	
20816810-4	2010	The present study was designed to examine a role of pertussis toxin-sensitive G protein, phosphatidylinositol 3-kinase/Akt signaling pathway and endogenous nitric oxide in the antiarrhythmic effect of rilmenidine.	Rilmenidine	201-212	AKT serine/threonine kinase 1	Rattus norvegicus	119-122	
20816810-8	2010	We also performed Western blot analysis to determine phosphorylation of Akt and glycogen synthase kinase 3beta, a direct Akt downstream target, following the central administration of rilmenidine.	Rilmenidine	184-195	AKT serine/threonine kinase 1	Rattus norvegicus	72-75	
20816810-8	2010	We also performed Western blot analysis to determine phosphorylation of Akt and glycogen synthase kinase 3beta, a direct Akt downstream target, following the central administration of rilmenidine.	Rilmenidine	184-195	AKT serine/threonine kinase 1	Rattus norvegicus	121-124	
20816810-10	2010	Rilmenidine increased Akt and glycogen synthase kinase 3beta phosphorylation (28+-13% and 32+-13%, respectively), and this action was abolished by wortmannin.	Rilmenidine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	22-25	
20816810-11	2010	The present results demonstrated that pertussis toxin-sensitive G protein, phosphatidylinositol 3-kinase-Akt-GSK3beta signaling pathway and endogenous nitric oxide may play a key role in antiarrhythmic effect of centrally administered rilmenidine.	Rilmenidine	235-246	AKT serine/threonine kinase 1	Rattus norvegicus	105-108