PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32702607-3 2020 In the face of such threats, a more effective antidote against organophosphonate acetylcholinesterase (AChE) inhibitors is needed, one that can freely penetrate into the central nervous system (CNS) through the blood-brain barrier (BBB). Organophosphonates 63-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 2362084-3 1990 This work was done to identify more clearly the nature of phosphinylated AChE with regard to oxime reactivation potency and the potential of phosphinates as pretreatment drugs to protect AChE against organophosphonate poisoning. Organophosphonates 200-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 2362084-3 1990 This work was done to identify more clearly the nature of phosphinylated AChE with regard to oxime reactivation potency and the potential of phosphinates as pretreatment drugs to protect AChE against organophosphonate poisoning. Organophosphonates 200-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 3783578-2 1986 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro. Organophosphonates 129-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 566114-0 1978 Fluorescent phosphonate label for serine hydrolases, pyrenebutyl methylphosphonofluoridate: reaction with acetylcholinesterase. Organophosphonates 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 32702607-3 2020 In the face of such threats, a more effective antidote against organophosphonate acetylcholinesterase (AChE) inhibitors is needed, one that can freely penetrate into the central nervous system (CNS) through the blood-brain barrier (BBB). Organophosphonates 63-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 22982773-4 2013 Our objective was to identify common mechanism(s) among OP-AChE conjugates of phosphates, phosphonates and phosphoramidates that result in resistance to oxime reactivation. Organophosphonates 90-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. Organophosphonates 61-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 20189400-0 2010 Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase. Organophosphonates 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 19536291-1 2009 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Organophosphonates 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 19536291-1 2009 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Organophosphonates 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 19536291-2 2009 Design of effective AChE reactivators as antidotes to various organophosphonates requires information on how the reactivators interact with the phosphonylated AChEs. Organophosphonates 62-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 10653663-3 2000 While AChE adducts with phosphonates and phosphates are known to age through scission of the alkoxy C-O bond, the aging path for adducts with phosphoroamidates (P-N agents) like the nerve agent N,N-dimethylphosphonocyanoamidate (tabun) is not clear. Organophosphonates 24-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 17382909-9 2007 These results in conjunction with previous data with organophosphates and organophosphonates emphasizes the necessity for kinetic studies as basis for future work on structural analysis with human AChE and for the development of effective broad-spectrum oximes. Organophosphonates 74-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 16429526-0 2005 Acetylcholinesterase mutants: oxime-assisted catalytic scavengers of organophosphonates. Organophosphonates 69-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18821801-1 2008 Two diastereomers of a phosphonate analog 6 of the AChE inhibitor cyclophostin were synthesized. Organophosphonates 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 8718893-0 1996 Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Organophosphonates 96-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 2037866-5 1991 Examples of acetylcholinesterase inhibition by two diagonally different phosphonate inhibitors are used for illustrating accuracy and precision of the competitive irreversible inhibition technique at different levels of enzyme saturation with inhibitor and substrate. Organophosphonates 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 1890690-7 1991 The individual mean values of the ki for each inhibitor in each class (phosphonate or phosphinate) were different with respect to each AChE, which may be a reflection of differences in enzyme configuration, whereas the general rank order of inhibitor potency within each class, reflected by the ki, was similar with respect to each AChE, which may be related to similar active centers. Organophosphonates 71-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 7619798-3 1995 "Pushing" of an alkoxy ligand by Glu199 and the numerous small van der Waals interactions promote dealkylation in phosphonate adducts of AChE much more effectively than any other enzyme. Organophosphonates 114-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 7619798-5 1995 Stabilization of the developing negative charge on the phosphonates in the soman-inhibited PSCS adducts of serine hydrolases is by electrophilic residues in the oxyanion hole (AChE) and the protonated catalytic His. Organophosphonates 55-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180