PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26856854-4	2016	OBJECTIVES: This study aimed to determine the effect of extensive MDMA self-administration on behavioral responses to the 5-HT(1A) agonist, 8-hydroxy-2-(n-dipropylamino)tetralin (8-OH-DPAT), and the 5-HT(1B/1A) agonist, RU 24969.	8-Hydroxy-2-(di-n-propylamino)tetralin	179-188	5-hydroxytryptamine receptor 1B	Rattus norvegicus	199-206	
19014464-5	2008	The 5-HT1A, 5-HT1B and 5-HT1D receptor agonists 8-OH-DPAT (3 microM), CP93129 (3 microM) and L694247 (3 microM), but not the 5-HT1F receptor agonist LY344864 (1 - 3 microM) inhibited evoked IPSCs.	8-Hydroxy-2-(di-n-propylamino)tetralin	48-57	5-hydroxytryptamine receptor 1B	Rattus norvegicus	12-18	
1836757-5	1991	Transient expression of this clone demonstrated high-affinity binding of [3H]5-HT with a pharmacological profile corresponding to that of the 5-HT1B subtype: 5-CT, 5-HT greater than propranolol greater than methysergide greater than rauwolscine greater than 8-OH-DPAT.	8-Hydroxy-2-(di-n-propylamino)tetralin	258-267	5-hydroxytryptamine receptor 1B	Rattus norvegicus	142-148	
9085496-5	1996	Both CGS-12066 and 8-OH-DPAT (5HT1B and 5HT1A receptor agonists, respectively) suppressed XII nerve activity in a dose-dependent manner by about 20%.	8-Hydroxy-2-(di-n-propylamino)tetralin	19-28	5-hydroxytryptamine receptor 1B	Rattus norvegicus	30-35	
8734491-7	1996	Although the antagonism of the 8-OH-DPAT-induced decrease of 5-HT levels by (-)-pindolol and (+/-)-tertatolol is likely to be related to their 5-HT1A antagonist properties, their ability to increase extracellular 5-HT levels when given alone may involve interactions with 5-HT1B receptors at hippocampal 5-HT terminals.	8-Hydroxy-2-(di-n-propylamino)tetralin	31-40	5-hydroxytryptamine receptor 1B	Rattus norvegicus	272-278	
11249960-3	2001	In both DRN and MRN, 5-HT release on short trains was reduced by the selective 5-HT(1A) agonist 8-OH-DPAT (1 microM), an effect blocked by the selective 5-HT(1A) antagonist WAY 100635 (0.1 microM) but not by SB 216641 (0.05 and 0.2 microM) or BRL 15572 (0.5 microM), selective antagonists at the 5-HT(1B) and 5-HT(1D) receptors respectively.	8-Hydroxy-2-(di-n-propylamino)tetralin	96-105	5-hydroxytryptamine receptor 1B	Rattus norvegicus	296-303	
8158130-3	1994	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 20 microM), a 5-HT1A agonist, increased ACh levels, whereas 7-trifluoromethyl-4-(4-methyl-1-piperazinyl)-pyrrolo[1,2-a]quinoxaline (CGS-12066B; 100 microM), a 5-HT1B agonist, decreased it.	8-Hydroxy-2-(di-n-propylamino)tetralin	0-38	5-hydroxytryptamine receptor 1B	Rattus norvegicus	210-216	
8158130-3	1994	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 20 microM), a 5-HT1A agonist, increased ACh levels, whereas 7-trifluoromethyl-4-(4-methyl-1-piperazinyl)-pyrrolo[1,2-a]quinoxaline (CGS-12066B; 100 microM), a 5-HT1B agonist, decreased it.	8-Hydroxy-2-(di-n-propylamino)tetralin	40-49	5-hydroxytryptamine receptor 1B	Rattus norvegicus	210-216	
8361548-6	1993	In addition, by blocking the 5-HT1B sites with 100 nM CP 93129, the remaining population of [125I]GTI binding sites could be studied and was found to have high affinity for PAPP, rauwolscine and 8-OH-DPAT.	8-Hydroxy-2-(di-n-propylamino)tetralin	195-204	5-hydroxytryptamine receptor 1B	Rattus norvegicus	29-35	
2524390-3	1989	The putative 5-HT1B agonist, 1-(3-trifluoromethylphenyl)piperazine (TFMPP), had a weak effect on the responses to DOI or 8-OHDPAT.	8-Hydroxy-2-(di-n-propylamino)tetralin	121-129	5-hydroxytryptamine receptor 1B	Rattus norvegicus	13-19	
20504589-3	1990	Competition studies employing the 5-HT(1B) selective agonist RU24969, in the presence of 100 nM 8-OH-DPAT, indicated that RU24969 demonstrated high affinity (K(i = 1.1 nM)) competitive inhibition for 26.2 +/- 1.4% of all [(3)H]5-HT binding sites.	8-Hydroxy-2-(di-n-propylamino)tetralin	96-105	5-hydroxytryptamine receptor 1B	Rattus norvegicus	34-41	
2530590-7	1989	It is concluded that 8-OH-DPAT-induced increase in serum corticosterone concentration results from its action at a site different than the adrenal cortex and is mediated by postsynaptic 5-HT1A receptors, whereas other subtypes (5-HT1B, 5-HT2, 5-HT3) of 5-HT receptors do not participate in this response.	8-Hydroxy-2-(di-n-propylamino)tetralin	21-30	5-hydroxytryptamine receptor 1B	Rattus norvegicus	228-234	
1829611-5	1991	Clonidine (an alpha 2-agonist) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, a 5-HT1A agonist) induced hyperphagia and 1-(3-trifluoromethylphenyl)piperazine (TFMPP, a 5-HT1B agonist) induced hypophagia dose-dependently in both rat lines.	8-Hydroxy-2-(di-n-propylamino)tetralin	35-73	5-hydroxytryptamine receptor 1B	Rattus norvegicus	176-182	
1829611-5	1991	Clonidine (an alpha 2-agonist) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, a 5-HT1A agonist) induced hyperphagia and 1-(3-trifluoromethylphenyl)piperazine (TFMPP, a 5-HT1B agonist) induced hypophagia dose-dependently in both rat lines.	8-Hydroxy-2-(di-n-propylamino)tetralin	75-84	5-hydroxytryptamine receptor 1B	Rattus norvegicus	176-182	
1834089-1	1991	In order to establish whether the 5-HT1A or the 5HT1B agonists, 8-OH-DPAT or TFMPP, produce their facilitatory or inhibitory actions on masculine sexual behaviour via a mechanism involving: (a) the serotonin synthesis or release; (b) the stimulation of presynaptic receptors, or (c) the stimulation of somatodendritic receptors, three series of experiments were performed.	8-Hydroxy-2-(di-n-propylamino)tetralin	64-73	5-hydroxytryptamine receptor 1B	Rattus norvegicus	48-53	
2970974-2	1988	8-OH-DPAT-induced feeding was blocked by metergoline which has comparable affinity for 5-HT1A, 5-HT1B, 5-HT1C and 5-HT2 receptors.	8-Hydroxy-2-(di-n-propylamino)tetralin	0-9	5-hydroxytryptamine receptor 1B	Rattus norvegicus	95-101	
3293039-5	1988	8-OH DPAT and TFMPP also serve as training drugs; the 8-OH DPAT-stimulus generalizes to other 5-HT1A agonists, but not to 5-HT1B or 5-HT2 agonists, whereas the TFMPP-stimulus generalizes to other 5-HT1B agonists, but not to 5-HT1A or 5-HT2 agonists.	8-Hydroxy-2-(di-n-propylamino)tetralin	54-63	5-hydroxytryptamine receptor 1B	Rattus norvegicus	196-202	
3352865-4	1988	The pEC40 values of 5-HT agonists tested, determined from release assays, significantly correlated with the relative affinities (pKD"s) of these compounds for the binding of [3H]5-HT to the 5-HT1B receptor subtype in the presence of 2 microM 8-OHDPAT, as determined from radioligand binding studies (r = 0.98, P = 0.003).	8-Hydroxy-2-(di-n-propylamino)tetralin	242-250	5-hydroxytryptamine receptor 1B	Rattus norvegicus	190-196	
2947981-4	1986	The "non-5-HT1A" sites labeled by 3H-5-HT in the presence of 0.1 microM 8-OH-DPAT corresponded mainly to 5-HT1B sites.	8-Hydroxy-2-(di-n-propylamino)tetralin	72-81	5-hydroxytryptamine receptor 1B	Rattus norvegicus	105-111	
2883013-5	1987	Evidence suggests that the above action of 8-OH-DPAT is mediated by 5-HT1A receptors since it was antagonised by the 5-HT1A antagonist spiperone but not by the 5-HT2 antagonist ketanserin and was not mimicked by the 5-HT1B agonist RU 24969.	8-Hydroxy-2-(di-n-propylamino)tetralin	43-52	5-hydroxytryptamine receptor 1B	Rattus norvegicus	216-222	
3160596-0	1985	Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites.	8-Hydroxy-2-(di-n-propylamino)tetralin	43-52	5-hydroxytryptamine receptor 1B	Rattus norvegicus	82-88	
3002805-9	1985	The low affinity of 5-HT1B recognition sites for some 5-HT1A, 5-HT1C and 5-HT2 selective compounds (e.g. 8-OH-DPAT, mesulergine, ketanserin) suggests that 5-HT1B recognition sites are pharmacologically different from 5-HT1A, 5-HT1C and 5-HT2 recognition sites.	8-Hydroxy-2-(di-n-propylamino)tetralin	105-114	5-hydroxytryptamine receptor 1B	Rattus norvegicus	20-26	
2941817-6	1986	In rats the hypothermia induced by 8-OH-DPAT was partially antagonised by TVX Q 7821 while the behavioural "serotonin syndrome" induced by 8-OH-DPAT (a possible post-synaptic 5-HT1B-mediated effect) was unaffected by TVX Q 7821 as was the locomotion induced by RU 24969.	8-Hydroxy-2-(di-n-propylamino)tetralin	139-148	5-hydroxytryptamine receptor 1B	Rattus norvegicus	175-181	
2580582-2	1985	These techniques have also indicated that certain drugs appear to show sub-type specificity: 8-hydroxy-2-(di-n-propylamino)tetralin(8-OH-DPAT), a 5-HT1A agonist; 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1-H indole (RU 24969), a 5-HT1B agonist; and ritanserin, a 5-HT2 antagonist.	8-Hydroxy-2-(di-n-propylamino)tetralin	132-141	5-hydroxytryptamine receptor 1B	Rattus norvegicus	230-236