PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8798386-3	1996	Activation of ERK2 by the 5-HT1A receptor-selective agonist 8-hydroxy-N,N-dipropyl-2-aminotetralin hydrobromide (8-OH-DPAT) was inhibited completely by pertussis toxin and substantially by prolonged treatment of cells with phorbol 12-myristate 13-acetate.	8-Hydroxy-2-(di-n-propylamino)tetralin	60-111	mitogen-activated protein kinase 1	Homo sapiens	14-18	
8798386-3	1996	Activation of ERK2 by the 5-HT1A receptor-selective agonist 8-hydroxy-N,N-dipropyl-2-aminotetralin hydrobromide (8-OH-DPAT) was inhibited completely by pertussis toxin and substantially by prolonged treatment of cells with phorbol 12-myristate 13-acetate.	8-Hydroxy-2-(di-n-propylamino)tetralin	113-122	mitogen-activated protein kinase 1	Homo sapiens	14-18	
26876117-6	2016	Interestingly, co-incubation of heterodimer-expressing HEK 293 cells with clozapine and the 5-HT1 A R agonist 8-OH DPAT potentiated post-synaptic effects, especially with respect to ERK activation.	8-Hydroxy-2-(di-n-propylamino)tetralin	110-119	mitogen-activated protein kinase 1	Homo sapiens	182-185	
18607571-3	2008	Stimulation with the 5-HT(1A/7) receptor agonist, 8-OH-DPAT, reduced P-T(185)/Y(187)-ERK2.	8-Hydroxy-2-(di-n-propylamino)tetralin	50-59	mitogen-activated protein kinase 1	Homo sapiens	85-89	
18607571-5	2008	Pretreatment with the cholesterol sequestering agent, methyl-beta-cyclodextrin, before adding 8-OH-DPAT, significantly counteracted the inhibitory influence of 8-OH-DPAT on P-T(185)/Y(187)-ERK2 and P-S(133)-CREB.	8-Hydroxy-2-(di-n-propylamino)tetralin	160-169	mitogen-activated protein kinase 1	Homo sapiens	189-193	
12676358-7	2003	Finally, transient expression of kinase-negative PKCalpha eliminated the 8-OH-DPAT-evoked block on the H(2)O(2)-triggered caspase-3 stimulation, establishing PKCalpha as a link between ERK and caspase-3 (5-HT(1A)-R-->PLC-->ERK1/2-->PKCalpha-->caspase-3).	8-Hydroxy-2-(di-n-propylamino)tetralin	73-82	mitogen-activated protein kinase 1	Homo sapiens	185-188	
32396921-7	2020	In addition, mPFC infusion of 8-OH-DPAT increased the phosphorylation of signaling proteins downstream of BDNF, including mTOR, ERK, 4EBP1, and p70S6K.	8-Hydroxy-2-(di-n-propylamino)tetralin	30-39	mitogen-activated protein kinase 1	Homo sapiens	128-131