PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12354565-8	2002	8-OH-DPAT also reduced the levels of the upstream activator of Erk1/2, phosphorylated extracellular signal-regulated kinase kinase (phospho-MEK1/2), and at least one potential downstream target, the nuclear transcription factor phospho-Elk-1.	8-Hydroxy-2-(di-n-propylamino)tetralin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	63-69	
25957476-7	2015	treatment with FGF-2 and the 5-HT1A agonist 8-OHDPAT synergistically increased FGFR1 and ERK1/2 phosphorylation in the raphe midline area of the midbrain and in the RN33B cells.	8-Hydroxy-2-(di-n-propylamino)tetralin	44-52	mitogen activated protein kinase 3	Rattus norvegicus	89-95	
24679950-7	2014	The PKMzeta peptide blocker ZIP and MEK inhibitor U0126 significantly inhibited the increase in extracellular signal-regulated kinase 1/2 and cyclic adenosine monophosphate response element binding protein phosphorylation in the mitogen-activated protein kinase (MAPK) pathway and hippocampal NSC neurogenesis in response to fluoxetine and the 5-HT1A receptor agonist 8-OH DPAT.	8-Hydroxy-2-(di-n-propylamino)tetralin	368-377	mitogen activated protein kinase 3	Rattus norvegicus	96-137	
24679950-7	2014	The PKMzeta peptide blocker ZIP and MEK inhibitor U0126 significantly inhibited the increase in extracellular signal-regulated kinase 1/2 and cyclic adenosine monophosphate response element binding protein phosphorylation in the mitogen-activated protein kinase (MAPK) pathway and hippocampal NSC neurogenesis in response to fluoxetine and the 5-HT1A receptor agonist 8-OH DPAT.	8-Hydroxy-2-(di-n-propylamino)tetralin	368-377	mitogen activated protein kinase 3	Rattus norvegicus	263-267	
12354565-3	2002	In contrast to the effect in cells, the 5-HT(1A) receptor agonist 8-hydroxy-N,N-diproylaminotetralin (8-OH-DPAT) dose- and time-dependently decreased basal levels of phosphorylated Erk1/2 (phospho-Erk1/2) in rat hippocampus (ED(50) approximately 0.1 mg/kg, maximum approximately 90%) without altering total Erk1/2.	8-Hydroxy-2-(di-n-propylamino)tetralin	102-111	mitogen activated protein kinase 3	Rattus norvegicus	181-187	
12354565-3	2002	In contrast to the effect in cells, the 5-HT(1A) receptor agonist 8-hydroxy-N,N-diproylaminotetralin (8-OH-DPAT) dose- and time-dependently decreased basal levels of phosphorylated Erk1/2 (phospho-Erk1/2) in rat hippocampus (ED(50) approximately 0.1 mg/kg, maximum approximately 90%) without altering total Erk1/2.	8-Hydroxy-2-(di-n-propylamino)tetralin	102-111	mitogen activated protein kinase 3	Rattus norvegicus	197-203	
12354565-3	2002	In contrast to the effect in cells, the 5-HT(1A) receptor agonist 8-hydroxy-N,N-diproylaminotetralin (8-OH-DPAT) dose- and time-dependently decreased basal levels of phosphorylated Erk1/2 (phospho-Erk1/2) in rat hippocampus (ED(50) approximately 0.1 mg/kg, maximum approximately 90%) without altering total Erk1/2.	8-Hydroxy-2-(di-n-propylamino)tetralin	102-111	mitogen activated protein kinase 3	Rattus norvegicus	197-203