PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25206483-10	2013	These results suggest that 8-OH-DPAT inhibits Bax and caspase-3 expression, increases Bcl-2 expression, and reduces neural cell apoptosis, resulting in neuroprotection against diffuse axonal injury.	8-Hydroxy-2-(di-n-propylamino)tetralin	27-36	caspase 3	Rattus norvegicus	54-63	
26819921-0	2015	Effect of Buspirone, Fluoxetine and 8-OH-DPAT on Striatal Expression of Bax, Caspase-3 and Bcl-2 Proteins in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Rats.	8-Hydroxy-2-(di-n-propylamino)tetralin	36-45	caspase 3	Rattus norvegicus	77-86	
26819921-3	2015	In this study we investigated the effect of sub-chronic administration of buspirone, fluoxetine and 8-hydroxy-2-[di-n-propylamino]tetralin (8-OH-DPAT) in 6-hydroxydopamine (6-OHDA)-lesioned rats and assayed striatal concentrations of apoptotic (Bax, Caspase3) and anti-apoptotic (Bcl-2) proteins.	8-Hydroxy-2-(di-n-propylamino)tetralin	140-149	caspase 3	Rattus norvegicus	250-258	
26819921-6	2015	RESULTS: The results showed that the expression of Bax and caspase3 proteins was increased three weeks after 6-OHDA injection while they were decreased significantly in parkinsonian rats which were treated by buspirone, fluoxetine and 8-OH-DPAT.	8-Hydroxy-2-(di-n-propylamino)tetralin	235-244	caspase 3	Rattus norvegicus	59-67	
15661577-5	2005	In addition, 8-OH-DPAT inhibited the H(2)O(2)-induced elevation of glutamate release into the medium and cytosolic Ca(2+) concentration ([Ca(2+)](c)), generation of reactive oxygen species (ROS), and caspase-3 activity.	8-Hydroxy-2-(di-n-propylamino)tetralin	13-22	caspase 3	Rattus norvegicus	200-209	
12604665-4	2003	NMDA-induced caspase-3 activity and DNA fragmentation were almost completely blocked by the 5-HT1A agonists 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and (R)-5-fluoro-8 hydroxy-2-(dipropylamino)-tetralin (R-UH-301).	8-Hydroxy-2-(di-n-propylamino)tetralin	108-147	caspase 3	Rattus norvegicus	13-22	
12604665-4	2003	NMDA-induced caspase-3 activity and DNA fragmentation were almost completely blocked by the 5-HT1A agonists 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and (R)-5-fluoro-8 hydroxy-2-(dipropylamino)-tetralin (R-UH-301).	8-Hydroxy-2-(di-n-propylamino)tetralin	149-158	caspase 3	Rattus norvegicus	13-22	
12604665-5	2003	Additionally, the protective effects of 8-OH-DPAT and R-UH-301 on NMDA-induced caspase-3 activation and apoptosis were reversed by pretreatment with the 5-HT1A antagonists N-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-N-(2-pyridinyl) cyclohexane carboxamide (WAY 100635) and S-UH-301, respectively.	8-Hydroxy-2-(di-n-propylamino)tetralin	40-49	caspase 3	Rattus norvegicus	79-88	
12604665-7	2003	Caspase-3 activation and DNA fragmentation in primary mesencephalic neurons were almost completely inhibited by 8-OH-DPAT.	8-Hydroxy-2-(di-n-propylamino)tetralin	112-121	caspase 3	Rattus norvegicus	0-9