PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31175950-0	2019	Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1.	triterpenoids	33-46	carboxylesterase 1	Homo sapiens	96-114	
31175950-2	2019	In this study, a series of natural pentacyclic triterpenoids were collected and their inhibitory effects against CES1 and CES2 were assayed using D-luciferin methyl ester (DME) and N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinolin- 6-yl)- 2-chloroacetamide (NCEN) as specific optical substrate for CES1, and CES2, respectively.	triterpenoids	47-60	carboxylesterase 1	Homo sapiens	113-117	
31175950-2	2019	In this study, a series of natural pentacyclic triterpenoids were collected and their inhibitory effects against CES1 and CES2 were assayed using D-luciferin methyl ester (DME) and N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinolin- 6-yl)- 2-chloroacetamide (NCEN) as specific optical substrate for CES1, and CES2, respectively.	triterpenoids	47-60	carboxylesterase 1	Homo sapiens	306-310	
29600756-9	2019	RESULTS: The results showed that more than 50 natural inhibitors of CES1 or CES2, including phenolic chemicals, triterpenoids, and tanshinones were found from herbs, whereas only few inducers of CES1 and CES2 were reported.	triterpenoids	112-125	carboxylesterase 1	Homo sapiens	68-72	
28713276-0	2017	Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1.	triterpenoids	48-61	carboxylesterase 1	Homo sapiens	111-129	
28713276-3	2017	To this end, a series of natural triterpenoids were collected and their inhibitory effects against human carboxylesterases (hCEs) were assayed using D-Luciferin methyl ester (DME) and 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate (DDAB) as specific optical substrate for hCE1, and hCE2, respectively.	triterpenoids	33-46	carboxylesterase 1	Homo sapiens	105-122	
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	triterpenoids	43-56	carboxylesterase 1	Homo sapiens	146-150	
28713276-6	2017	The inhibitory effects of these derivatives on hCEs were assayed and the structure-activity relationships of tested triterpenoids as hCE1 inhibitors were carefully investigated.	triterpenoids	116-129	carboxylesterase 1	Homo sapiens	133-137	
28713276-9	2017	3D-QSAR analysis of all tested triterpenoids including OA and UA derivatives provide new insights into the fine relationships linking between the inhibitory effects on hCE1 and the steric-electrostatic properties of triterpenoids.	triterpenoids	31-44	carboxylesterase 1	Homo sapiens	168-172	
28713276-9	2017	3D-QSAR analysis of all tested triterpenoids including OA and UA derivatives provide new insights into the fine relationships linking between the inhibitory effects on hCE1 and the steric-electrostatic properties of triterpenoids.	triterpenoids	216-229	carboxylesterase 1	Homo sapiens	168-172