PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31175950-0 2019 Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1. triterpenoids 33-46 carboxylesterase 1 Homo sapiens 96-114 31175950-2 2019 In this study, a series of natural pentacyclic triterpenoids were collected and their inhibitory effects against CES1 and CES2 were assayed using D-luciferin methyl ester (DME) and N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinolin- 6-yl)- 2-chloroacetamide (NCEN) as specific optical substrate for CES1, and CES2, respectively. triterpenoids 47-60 carboxylesterase 1 Homo sapiens 113-117 31175950-2 2019 In this study, a series of natural pentacyclic triterpenoids were collected and their inhibitory effects against CES1 and CES2 were assayed using D-luciferin methyl ester (DME) and N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinolin- 6-yl)- 2-chloroacetamide (NCEN) as specific optical substrate for CES1, and CES2, respectively. triterpenoids 47-60 carboxylesterase 1 Homo sapiens 306-310 28713276-0 2017 Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1. triterpenoids 48-61 carboxylesterase 1 Homo sapiens 111-129 29600756-9 2019 RESULTS: The results showed that more than 50 natural inhibitors of CES1 or CES2, including phenolic chemicals, triterpenoids, and tanshinones were found from herbs, whereas only few inducers of CES1 and CES2 were reported. triterpenoids 112-125 carboxylesterase 1 Homo sapiens 68-72 28713276-4 2017 Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2. triterpenoids 43-56 carboxylesterase 1 Homo sapiens 146-150 28713276-6 2017 The inhibitory effects of these derivatives on hCEs were assayed and the structure-activity relationships of tested triterpenoids as hCE1 inhibitors were carefully investigated. triterpenoids 116-129 carboxylesterase 1 Homo sapiens 133-137 28713276-9 2017 3D-QSAR analysis of all tested triterpenoids including OA and UA derivatives provide new insights into the fine relationships linking between the inhibitory effects on hCE1 and the steric-electrostatic properties of triterpenoids. triterpenoids 31-44 carboxylesterase 1 Homo sapiens 168-172 28713276-9 2017 3D-QSAR analysis of all tested triterpenoids including OA and UA derivatives provide new insights into the fine relationships linking between the inhibitory effects on hCE1 and the steric-electrostatic properties of triterpenoids. triterpenoids 216-229 carboxylesterase 1 Homo sapiens 168-172 28713276-3 2017 To this end, a series of natural triterpenoids were collected and their inhibitory effects against human carboxylesterases (hCEs) were assayed using D-Luciferin methyl ester (DME) and 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate (DDAB) as specific optical substrate for hCE1, and hCE2, respectively. triterpenoids 33-46 carboxylesterase 1 Homo sapiens 105-122