PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19100343-8 2009 KHBJ-9B and the combination of 3 triterpenoids markedly inhibited the level of IL-1beta and TNF-alpha, and down-regulated the level of aggrecanases, ADAMTS-4, ADAMTS-5, MMP-1 and MMP-13, and up-regulated TIMP-3 in human cartilage explants culture. triterpenoids 33-46 ADAM metallopeptidase with thrombospondin type 1 motif 4 Homo sapiens 149-157