PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28851867-3 2017 Triterpenoids are a class of small molecules with potent immunomodulatory activity linked to activation of Nrf2 target genes, and can also suppress the manifestations of experimental autoimmune encephalomyelitis (EAE). triterpenoids 0-13 NFE2 like bZIP transcription factor 2 Homo sapiens 107-111 28856520-3 2018 However, pentacyclic triterpenoids also modulate the expression and transcriptional activities of Nrf2 and exert cytoprotective effects. triterpenoids 21-34 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 24533814-3 2014 However, most known inducers (e.g., triterpenoids, isothiocyanates and sulfoxythiocarbamates) that activate the ARE system through electrophilic attacks on the cysteine sulfhydryl group of Keap1 also disrupt theKeap1-Nrf2 interaction. triterpenoids 36-49 NFE2 like bZIP transcription factor 2 Homo sapiens 217-221 27242339-5 2016 All the above triterpenoids increased the level of an Nrf2-targeted gene, NADPH:quinone oxidoreductase-1, in normal human epidermal keratinocytes. triterpenoids 14-27 NFE2 like bZIP transcription factor 2 Homo sapiens 54-58 25511620-5 2015 This review article is focused on triterpenoids that activate Nrf2, and their potential for reducing oxidative stress in SCD as an approach to prevent organ dysfunction associated with this disease. triterpenoids 34-47 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 24783956-8 2014 NRF2 inducers such as phytochemical isothyocyanates and synthetic triterpenoids, have been discovered and used in model systems of oxidant-induced lung diseases, and data suggest a potential for clinical interventions. triterpenoids 66-79 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 24486487-2 2014 Several synthetic oleanolic triterpenoids including dihydro-CDDO-trifluoroethyl amide (dh404) appear to be potent activators of Nrf2 and exhibit chemopreventive promises in multiple disease models. triterpenoids 28-41 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 28024463-0 2017 In silico Evidence for Binding of Pentacyclic Triterpenoids to Keap1-Nrf2 Protein-Protein Binding Site. triterpenoids 46-59 NFE2 like bZIP transcription factor 2 Homo sapiens 69-73 28024463-3 2017 Naturally occurring pentacyclic triterpenoids (PTs) and their synthetic derivatives are projected as activators of Nrf2 signalling. triterpenoids 32-45 NFE2 like bZIP transcription factor 2 Homo sapiens 115-119 27989132-5 2016 Many dietary phytochemicals with cancer chemopreventive properties, such as polyphenols, isothiocyanates, and triterpenoids, exert antioxidant and anti-inflammatory functions by activating the Nrf2 pathway. triterpenoids 110-123 NFE2 like bZIP transcription factor 2 Homo sapiens 193-197 25536195-2 2014 Synthetic triterpenoids, including CDDO-Me, act as anti-inflammatory and antioxidant modulators primarily by inducing the transcription factor Nrf2 to activate downstream genes containing antioxidant response elements (AREs). triterpenoids 10-23 NFE2 like bZIP transcription factor 2 Homo sapiens 143-147 24009841-0 2012 Targeting nrf2-mediated gene transcription by triterpenoids and their derivatives. triterpenoids 46-59 NFE2 like bZIP transcription factor 2 Homo sapiens 10-14 24659938-2 2014 Low nanomolar concentrations of triterpenoids inhibit the induction of inflammatory cytokines, and these drugs are potent activators of the Nrf2 cytoprotective pathway. triterpenoids 32-45 NFE2 like bZIP transcription factor 2 Homo sapiens 140-144 24659938-5 2014 In an experimental model of lung cancer, the triterpenoids activated the Nrf2 pathway, as seen by induction of the cytoprotective enzyme NQO1, and reduced the toxicity of carboplatin and paclitaxel. triterpenoids 45-58 NFE2 like bZIP transcription factor 2 Homo sapiens 73-77 23581983-8 2013 The most effective Keap1-Nrf2 activators are synthetic oleanane triterpenoids. triterpenoids 64-77 NFE2 like bZIP transcription factor 2 Homo sapiens 25-29 24009841-4 2012 Activation of Nrf2 by triterpenoids induces the expression of phase 2 detoxifying and antioxidant enzymes such as NAD(P)H quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) - proteins which can protect cells or tissues against various toxic metabolites. triterpenoids 22-35 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 17822364-0 2007 Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. triterpenoids 56-69 NFE2 like bZIP transcription factor 2 Homo sapiens 40-44 19732782-7 2010 Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. triterpenoids 331-344 NFE2 like bZIP transcription factor 2 Homo sapiens 163-167 19732782-7 2010 Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. triterpenoids 331-344 NFE2 like bZIP transcription factor 2 Homo sapiens 163-167 15930299-0 2005 The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. triterpenoids 14-27 NFE2 like bZIP transcription factor 2 Homo sapiens 100-104