PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9876215-4 1999 Donepezil HCl, for example, is a piperidine-based, reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other ChE inhibitors and rationally designed for the symptomatic treatment of AD. piperidine 33-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 11830754-3 2001 Donepezil is a piperidine-based, reversible acetylcholinesterase inhibitor, that is chemically unrelated to other cholinesterase inhibitors. piperidine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 11830754-3 2001 Donepezil is a piperidine-based, reversible acetylcholinesterase inhibitor, that is chemically unrelated to other cholinesterase inhibitors. piperidine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-64 11249555-3 1999 Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE). piperidine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 11249555-3 1999 Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE). piperidine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 10332937-0 1999 Clinical benefits of a new piperidine-class AChE inhibitor. piperidine 27-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 11343620-4 2000 Donepezil is a second-generation, piperidine-class, selective and reversible acetylcholinesterase inhibitor. piperidine 34-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 9876215-4 1999 Donepezil HCl, for example, is a piperidine-based, reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other ChE inhibitors and rationally designed for the symptomatic treatment of AD. piperidine 33-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 9853200-1 1998 Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer"s disease (AD). piperidine 19-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 9853200-1 1998 Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer"s disease (AD). piperidine 19-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 34964956-6 2021 The dihydro-pyrrole alkaloid tiliine A, the piperidine alkaloid tiliamine B, and the acetylated piperidine alkaloid tilacetine A were characterized as acetylcholinesterase inhibitors. piperidine 44-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 33583373-5 2021 Interestingly, synthetic xanthone derivatives with complex substituents such as alkyl, pyrrolidine, piperidine and morpholine have shown greater acetylcholinesterase inhibition activities. piperidine 100-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 19603258-3 2009 MATERIALS AND METHODS: Support vector machine classification and regression models with molecular descriptors derived from Shape Signatures and the Molecular Operating Environment (MOE) application software were built and tested using a set of piperidine AChE inhibitors (N = 110). piperidine 244-254 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 30267791-3 2018 This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE). piperidine 160-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-238 30265992-2 2018 It was found that substituted salicylaldehydes conjugated to aminobenzamide through piperidine would produce efficient reactivators for sarin, VX and tabun inhibited hAChE, such as L6M1R3, L6M1R5 to L6M1R7, L4M1R3 and L4M1R5 to L4M1R7. piperidine 84-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-171 30047333-0 2018 2D & 3D-QSAR Study on Novel Piperidine and Piperazine Derivatives as Acetylcholinesterase Enzyme Inhibitors. piperidine 28-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-96 30680760-4 2019 For the compounds containing pyrroline or piperidine side chain, the bioactivity in AChE inhibition is much intense than those containing N,N-diethylamino side chain. piperidine 42-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 26105711-0 2015 In vitro evaluation and in silico screening of synthetic acetylcholinesterase inhibitors bearing functionalized piperidine pharmacophores. piperidine 112-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 20422942-2 2010 BACKGROUND: Donepezil hydrochloride (CAS 120014-06-4) is a piperidine-based, reversible inhibitor of the enzyme acetylcholinesterase (AChE). piperidine 59-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 20422942-2 2010 BACKGROUND: Donepezil hydrochloride (CAS 120014-06-4) is a piperidine-based, reversible inhibitor of the enzyme acetylcholinesterase (AChE). piperidine 59-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 17681794-0 2007 Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer"s disease therapeutics. piperidine 57-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 17681794-1 2007 With the goal of developing Alzheimer"s disease therapeutics, we have designed and synthesized new piperidine derivatives having dual action of acetylcholinesterase (AChE) and beta-amyloid peptide (Abeta) aggregation inhibition. piperidine 99-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 17681794-1 2007 With the goal of developing Alzheimer"s disease therapeutics, we have designed and synthesized new piperidine derivatives having dual action of acetylcholinesterase (AChE) and beta-amyloid peptide (Abeta) aggregation inhibition. piperidine 99-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 14622273-1 2003 E2020 (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl)piperidine hydrochloride is a piperidine-based acetylcholinesterase (AChE) inhibitor that was approved for the treatment of Alzheimer"s disease in the United States. piperidine 62-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135