PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24269480-2	2013	SAR optimization led to the identification of isoindoline 3c and piperidine 4a which showed good in vitro binding and functional activities, as well as improved aqueous solubility.	piperidine	65-75	sarcosine dehydrogenase	Homo sapiens	0-3	
26832218-4	2016	The synthesis and SAR of these substituted piperidine and piperazine CGRP antagonists are discussed.	piperidine	43-53	sarcosine dehydrogenase	Homo sapiens	18-21	
22197137-2	2012	The three sites impacting SAR are substitutions on the aryl group (R(1)), the piperidine nitrogen (R(2)), and the amide (R(3)).	piperidine	78-88	sarcosine dehydrogenase	Homo sapiens	26-29	
16690312-2	2006	SAR on the electron-induced effects of various linkers as well as substituents on the phenyl rings and the piperidine nitrogen has been investigated.	piperidine	107-117	sarcosine dehydrogenase	Homo sapiens	0-3	
21324684-0	2011	Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.	piperidine	79-89	sarcosine dehydrogenase	Homo sapiens	68-71	
21324684-1	2011	SAR study of the piperidine moiety in a series of quinolizidinone carboxylic acid M(1) positive allosteric modulators was examined.	piperidine	17-27	sarcosine dehydrogenase	Homo sapiens	0-3	
18926711-3	2008	In this report, we describe SAR in this series of compounds and show that the 3,4-methylenedioxybenzoyl (piperonyloyl) group on the nitrogen of piperidine and lipophilic substitution at the C(6)-position of pyrimidine are important for this inhibitory activity.	piperidine	144-154	sarcosine dehydrogenase	Homo sapiens	28-31	
17768046-1	2007	SAR about the piperidine core in a series of MC4R agonists is described.	piperidine	14-24	sarcosine dehydrogenase	Homo sapiens	0-3	
12161132-1	2002	By employing a stereosimplification approach, a thorough SAR exploration of the piperidine region of Sch 206272 was possible through a practical and efficient synthesis of substituted cyclic ureas.	piperidine	80-90	sarcosine dehydrogenase	Homo sapiens	57-60	
12109901-0	2002	SAR studies of piperidine-based analogues of cocaine.	piperidine	15-25	sarcosine dehydrogenase	Homo sapiens	0-3