PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24269480-2 2013 SAR optimization led to the identification of isoindoline 3c and piperidine 4a which showed good in vitro binding and functional activities, as well as improved aqueous solubility. piperidine 65-75 sarcosine dehydrogenase Homo sapiens 0-3 26832218-4 2016 The synthesis and SAR of these substituted piperidine and piperazine CGRP antagonists are discussed. piperidine 43-53 sarcosine dehydrogenase Homo sapiens 18-21 22197137-2 2012 The three sites impacting SAR are substitutions on the aryl group (R(1)), the piperidine nitrogen (R(2)), and the amide (R(3)). piperidine 78-88 sarcosine dehydrogenase Homo sapiens 26-29 16690312-2 2006 SAR on the electron-induced effects of various linkers as well as substituents on the phenyl rings and the piperidine nitrogen has been investigated. piperidine 107-117 sarcosine dehydrogenase Homo sapiens 0-3 21324684-0 2011 Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series. piperidine 79-89 sarcosine dehydrogenase Homo sapiens 68-71 21324684-1 2011 SAR study of the piperidine moiety in a series of quinolizidinone carboxylic acid M(1) positive allosteric modulators was examined. piperidine 17-27 sarcosine dehydrogenase Homo sapiens 0-3 18926711-3 2008 In this report, we describe SAR in this series of compounds and show that the 3,4-methylenedioxybenzoyl (piperonyloyl) group on the nitrogen of piperidine and lipophilic substitution at the C(6)-position of pyrimidine are important for this inhibitory activity. piperidine 144-154 sarcosine dehydrogenase Homo sapiens 28-31 17768046-1 2007 SAR about the piperidine core in a series of MC4R agonists is described. piperidine 14-24 sarcosine dehydrogenase Homo sapiens 0-3 12161132-1 2002 By employing a stereosimplification approach, a thorough SAR exploration of the piperidine region of Sch 206272 was possible through a practical and efficient synthesis of substituted cyclic ureas. piperidine 80-90 sarcosine dehydrogenase Homo sapiens 57-60 12109901-0 2002 SAR studies of piperidine-based analogues of cocaine. piperidine 15-25 sarcosine dehydrogenase Homo sapiens 0-3