PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21738715-8	2011	PS feeding resulted in a dose-dependent decrease of fractional cholesterol absorption (~2-7-fold reduction) in wild-type mice and ~80% reduction in Abcg5(-/-) mice.	Phytosterols	0-2	ATP binding cassette subfamily G member 5	Mus musculus	148-153	
23380580-0	2013	Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice.	Phytosterols	0-11	ATP binding cassette subfamily G member 5	Mus musculus	39-44	
23380580-5	2013	The high-phytosterol diet was extremely toxic to the ABCG5/G8 knockout mice but had no adverse effects on wild-type mice.	Phytosterols	9-20	ATP binding cassette subfamily G member 5	Mus musculus	53-58	
23380580-7	2013	This study is the first to report such toxic effects of phytosterol accumulation in ABCG5/G8 knockout mice.	Phytosterols	56-67	ATP binding cassette subfamily G member 5	Mus musculus	84-89	
22715101-0	2012	The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation.	Phytosterols	128-139	ATP binding cassette subfamily G member 5	Mus musculus	4-9	
21738715-9	2011	Furthermore, PS feeding led to a strong, dose-independent induction of neutral sterol excretion (3.4-fold in wild-types and 2.7-fold in Abcg5(-/-) mice) without changes in biliary cholesterol secretion.	Phytosterols	13-15	ATP binding cassette subfamily G member 5	Mus musculus	136-141	
19846887-8	2010	ABCG5 and ABCG8 form a functional complex that limits dietary phytosterol accumulation.	Phytosterols	62-73	ATP binding cassette subfamily G member 5	Mus musculus	0-5	
18692849-6	2009	Conclusive studies using ABCA1 and ABCG5/G8-deficient mice have demonstrated that the phytosterol-mediated inhibition of intestinal cholesterol absorption is independent of these ATP-binding cassette (ABC) transporters.	Phytosterols	86-97	ATP binding cassette subfamily G member 5	Mus musculus	35-40	
19306529-1	2009	PURPOSE OF REVIEW: This review summarizes recent developments in the activity, regulation, and physiology of the ABCG5 ABCG8 (G5G8) transporter and the use of its xenobiotic substrates, phytosterols, as cholesterol lowering agents in the treatment of cardiovascular disease.	Phytosterols	186-198	ATP binding cassette subfamily G member 5	Mus musculus	113-118	
18692849-8	2009	The accumulation of phytosterols in ABCG5/G8-deficient mice, which develop features of human sitosterolaemia, disrupts cholesterol homeostasis by affecting sterol regulatory element-binding protein (SREBP)-2 processing and liver X receptor (LXR) regulatory pathways.	Phytosterols	20-32	ATP binding cassette subfamily G member 5	Mus musculus	36-41	
15939057-2	2005	The increased activity of ATP-binding cassette (ABC) transporters ABCA1, ABCG5 and ABCG8, or, alternatively, a decrease in Niemann-Pick C1 Like 1 (NPC1L1) could mediate the reduction in intestinal cholesterol absorption caused by phytosterols.	Phytosterols	230-242	ATP binding cassette subfamily G member 5	Mus musculus	73-78	
15939057-7	2005	ABCA1, ABCG5, ABCG8 and NPC1L1 mRNA levels were slightly reduced in the intestine of phytosterol-treated apoE(-/-) and LDLR(-/-) mice, but increased in C57BL/6J-treated mice.	Phytosterols	85-96	ATP binding cassette subfamily G member 5	Mus musculus	7-12	
12847102-2	2003	LXR activation induces the expression of ATP-binding cassette (ABC) transporters, such as ABCG5 and ABCG8, which inhibit intestinal absorption of cholesterol and phytosterols.	Phytosterols	162-174	ATP binding cassette subfamily G member 5	Mus musculus	90-95