PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10614779-4	1999	Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha, the PMA-induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline, 3,4-dichloroisocoumarin (3,4-DCI), iodoacetamide, and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone (TPCK).	1,10-phenanthroline	231-250	tumor necrosis factor	Homo sapiens	167-176	
10614779-5	1999	Hydroxamate MMP inhibitors and 1,10-phenanthroline inhibited the processing of TNF-alpha on the cell surface, whereas 3,4-DCI, iodoacetamide, and TPCK inhibited the transport of TNF-alpha to the cell surface.	1,10-phenanthroline	31-50	tumor necrosis factor	Homo sapiens	79-88	
7569774-5	1995	Furthermore, 1,10-phenanthroline also reduced PMA-induced down-regulation of TNF-receptors in both cell lines as judged by TNF-binding to cells.	1,10-phenanthroline	13-32	tumor necrosis factor	Homo sapiens	77-80	
10090924-6	1999	The downmodulation of CXCR1 and CXCR2 by LPS and TNF-alpha was most dramatically inhibited by metalloproteinase inhibitors; 1, 10-phenanthroline and EDTA significantly attenuated LPS- and TNF-alpha-induced loss of CXCR1 and CXCR2 cell surface expression.	1,10-phenanthroline	124-144	tumor necrosis factor	Homo sapiens	188-197	
10090924-8	1999	In addition, while treatment of neutrophils with LPS and TNF-alpha inhibited IL-8 receptor-mediated calcium mobilization and IL-8-directed neutrophil chemotaxis, both 1, 10-phenanthroline and EDTA blocked these inhibitory processes.	1,10-phenanthroline	167-187	tumor necrosis factor	Homo sapiens	57-66	
7569774-5	1995	Furthermore, 1,10-phenanthroline also reduced PMA-induced down-regulation of TNF-receptors in both cell lines as judged by TNF-binding to cells.	1,10-phenanthroline	13-32	tumor necrosis factor	Homo sapiens	123-126	
7569774-6	1995	Reduced down-regulation and TNF-receptor shedding by 1,10-phenanthroline was reversed by Zn2+, indicating involvement of a Zn(2+)-dependent metalloprotease.	1,10-phenanthroline	53-72	tumor necrosis factor	Homo sapiens	28-31	
7962141-7	1994	It was discovered that cupric o-phenanthroline markedly potentiated the effects of TNF on the resistant CEM-SS cells leading to cell death.	1,10-phenanthroline	30-46	tumor necrosis factor	Homo sapiens	83-86	
25414128-3	2017	We found that O-phenanthroline reduced the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFalpha/IL-1beta exposure in an explant model.	1,10-phenanthroline	14-30	tumor necrosis factor	Homo sapiens	167-175	
25414128-4	2017	Interestingly, O-phenanthroline significantly inhibited matrix degradation in a TNFalpha/IL-1beta-dependent model of cartilage degeneration when compared to control and natural hypoxia (2.5% O2 ).	1,10-phenanthroline	15-31	tumor necrosis factor	Homo sapiens	80-88