PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34126010-1 2021 3"-Deoxy-3",4"-didehydro-cytidine triphosphate (ddhCTP) is a novel antiviral molecule produced by the enzyme viperin as part of the innate immune response. ddhCTP 48-54 radical S-adenosyl methionine domain containing 2 Homo sapiens 109-116 32232843-0 2020 ddhCTP produced by the radical-SAM activity of RSAD2 (viperin) inhibits the NAD+ -dependent activity of enzymes to modulate metabolism. ddhCTP 0-6 radical S-adenosyl methionine domain containing 2 Homo sapiens 47-52 32603630-4 2020 Most recently, however, viperin was demonstrated to catalyze the conversion of cytidine triphosphate (CTP) to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP), a previously unknown ribonucleotide. ddhCTP 140-146 radical S-adenosyl methionine domain containing 2 Homo sapiens 24-31 35128501-8 2022 Transcripts of viperin and CMPK2, enzymes responsible for ddhCTP synthesis, were amongst the five genes most highly correlated to ddhC abundance. ddhCTP 58-64 radical S-adenosyl methionine domain containing 2 Homo sapiens 15-22 32232843-0 2020 ddhCTP produced by the radical-SAM activity of RSAD2 (viperin) inhibits the NAD+ -dependent activity of enzymes to modulate metabolism. ddhCTP 0-6 radical S-adenosyl methionine domain containing 2 Homo sapiens 54-61 32232843-2 2020 Recently, it was found that RSAD2 catalyses transformation of cytidine triphosphate (CTP) to its analogue 3 -deoxy-3 ,4 -didehydro-CTP (ddhCTP). ddhCTP 136-142 radical S-adenosyl methionine domain containing 2 Homo sapiens 28-33 32232843-6 2020 We propose that ddhCTP regulates cellular metabolism in response to inflammatory stimuli such as viral infection, pointing to a broader function of RSAD2 than previously thought. ddhCTP 16-22 radical S-adenosyl methionine domain containing 2 Homo sapiens 148-153 30092190-3 2018 (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering insights into drug design. ddhCTP 99-105 radical S-adenosyl methionine domain containing 2 Homo sapiens 31-38 29925952-4 2018 Here we demonstrate that viperin catalyses the conversion of cytidine triphosphate (CTP) to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP), a previously undescribed biologically relevant molecule, via a SAM-dependent radical mechanism. ddhCTP 122-128 radical S-adenosyl methionine domain containing 2 Homo sapiens 25-32 29925952-5 2018 We show that mammalian cells expressing viperin and macrophages stimulated with IFNalpha produce substantial quantities of ddhCTP. ddhCTP 123-129 radical S-adenosyl methionine domain containing 2 Homo sapiens 40-47