PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34996525-7	2022	RESULTS: The Kaplan-Meier analysis showed association between the serum NFL tertiles and risk of cognitive stage transition in MCI (P = 0.002) and CU (P = 0.028) participants, analyzed separately.	Copper	147-149	neurofilament light chain	Homo sapiens	72-75	
23228886-9	2013	At a low concentration of THP, copper ions enhanced the modification of NF-L.	Copper	31-37	neurofilament light chain	Homo sapiens	72-76	
15388232-4	2004	Cu,Zn-SOD/H2O2-mediated modification of NF-L was significantly inhibited by radical scavenger, spin trap agents and copper chelators.	Copper	0-2	neurofilament light chain	Homo sapiens	40-44	
15388232-4	2004	Cu,Zn-SOD/H2O2-mediated modification of NF-L was significantly inhibited by radical scavenger, spin trap agents and copper chelators.	Copper	116-122	neurofilament light chain	Homo sapiens	40-44	
15388232-5	2004	Dityrosine crosslink formation was obtained in Cu,Zn-SOD/H2O2-mediated NF-L aggregates.	Copper	47-49	neurofilament light chain	Homo sapiens	71-75	
15388232-7	2004	This study suggests that copper-mediated NF-L modification may be closely related to oxidative reactions which play a critical role in neurodegenerative diseases.	Copper	25-31	neurofilament light chain	Homo sapiens	41-45	
9349538-4	1997	Neurofilament-L (NF-L), one of the most abundant proteins in motor neurons, bound multiple zinc atoms with sufficient affinity to potentially remove zinc from both wild-type and mutant SOD while having a lower affinity for copper.	Copper	223-229	neurofilament light chain	Homo sapiens	0-15	
14536032-0	2003	Oxidative modification of neurofilament-L by copper-catalyzed reaction.	Copper	45-51	neurofilament light chain	Homo sapiens	26-41	
14536032-2	2003	Since oxidative stress might play a critical role in the pathogenesis of neurodegenerative diseases, we investigated the role of copper and peroxide in the modification of NF-L.	Copper	129-135	neurofilament light chain	Homo sapiens	172-176	
14536032-3	2003	When disassembled NF-L was incubated with copper ion and hydrogen peroxide, then the aggregation of protein was proportional to copper and hydrogen peroxide concentrations.	Copper	42-48	neurofilament light chain	Homo sapiens	18-22	
14536032-3	2003	When disassembled NF-L was incubated with copper ion and hydrogen peroxide, then the aggregation of protein was proportional to copper and hydrogen peroxide concentrations.	Copper	128-134	neurofilament light chain	Homo sapiens	18-22	
14536032-4	2003	Dityrosine crosslink formation was obtained in copper-mediated NF-L aggregates.	Copper	47-53	neurofilament light chain	Homo sapiens	63-67	
14536032-5	2003	The copper-mediated modification of NF-L was significantly inhibited by thiol antioxidants, Nacetylcysteine, glutathione, and thiourea.	Copper	4-10	neurofilament light chain	Homo sapiens	36-40	
14536032-6	2003	A thioflavin-T binding assay was performed to determine whether the copper/H2O2 system-induced in vitro aggregation of NF-L displays amyloid-like characteristics.	Copper	68-74	neurofilament light chain	Homo sapiens	119-123	
14536032-8	2003	This study suggests that copper-mediated NF-L modification might be closely related to oxidative reactions which may play a critical role in neurodegenerative diseases.	Copper	25-31	neurofilament light chain	Homo sapiens	41-45	
9349538-4	1997	Neurofilament-L (NF-L), one of the most abundant proteins in motor neurons, bound multiple zinc atoms with sufficient affinity to potentially remove zinc from both wild-type and mutant SOD while having a lower affinity for copper.	Copper	223-229	neurofilament light chain	Homo sapiens	17-21	
34964348-9	2021	Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL.	Copper	29-31	neurofilament light chain	Homo sapiens	130-133