PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31793911-3 2020 Here, we show that 3,4-dihydroxyphenylglycolaldehyde, which is produced exclusively in noradrenergic neurons by monoamine oxidase A metabolism of norepinephrine, activated asparagine endopeptidase that cleaved Tau at residue N368 into aggregation- and propagation-prone forms, thus leading to LC degeneration and the spread of Tau pathology. 2-amino-5-fluoro-4-picoline 225-229 monoamine oxidase A Homo sapiens 112-131