PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33735724-0	2021	A novel flavonoid from Fissistigma cupreonitens, 5-hydroxy-7,8-dimethoxyflavanone, competitively inhibited the efflux function of human P-glycoprotein and reversed cancer multi-drug resistance.	5-hydroxy-7,8-dimethoxyflavanone	49-81	ATP binding cassette subfamily B member 1	Homo sapiens	136-150	
33735724-9	2021	5-hydroxy-7,8-dimethoxyflavanone slightly changed P-gp"s conformation and only stimulated ATPase at very high concentration (100 mug/ml).	5-hydroxy-7,8-dimethoxyflavanone	0-32	ATP binding cassette subfamily B member 1	Homo sapiens	50-54	
33735724-10	2021	The docking results showed that 5-hydroxy-7,8-dimethoxyflavanone and verapamil exhibited similar binding affinity to P-gp.	5-hydroxy-7,8-dimethoxyflavanone	32-64	ATP binding cassette subfamily B member 1	Homo sapiens	117-121	
33735724-11	2021	The MDR reversing effects were prominent in the vincristine group, the reversal folds were 23.01 and 13.03 when combined with 10 mug/ml 5-hydroxy-7,8-dimethoxyflavanone in the P-gp over-expressing cell line (ABCB1/Flp-In -293) and MDR cancer cell line (KB/VIN), respectively.	5-hydroxy-7,8-dimethoxyflavanone	136-168	ATP binding cassette subfamily B member 1	Homo sapiens	176-180	
33735724-11	2021	The MDR reversing effects were prominent in the vincristine group, the reversal folds were 23.01 and 13.03 when combined with 10 mug/ml 5-hydroxy-7,8-dimethoxyflavanone in the P-gp over-expressing cell line (ABCB1/Flp-In -293) and MDR cancer cell line (KB/VIN), respectively.	5-hydroxy-7,8-dimethoxyflavanone	136-168	ATP binding cassette subfamily B member 1	Homo sapiens	208-213	
33735724-12	2021	CONCLUSION: The present study demonstrated that 5-hydroxy-7,8-dimethoxyflavanone was a novel effective flavonoid in the P-gp efflux inhibition and in vitro cancer MDR reversion.	5-hydroxy-7,8-dimethoxyflavanone	48-80	ATP binding cassette subfamily B member 1	Homo sapiens	120-124