PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20404718-13 2010 CONCLUSIONS: These studies delineate a novel pathway of Vpr-induced apoptosis in RTEC, which is mediated by sustained ERK activation, resulting in caspase 8-mediated cleavage of BID to tBID, thereby facilitating Bax-mediated mitochondrial injury and apoptosis. tBID 185-189 mitogen-activated protein kinase 1 Homo sapiens 118-121