PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24464226-2 2014 Truncated Bid (tBid) induces Bax/Bak-dependent mitochondrial outer membrane permeability and the release of cytochrome c and Smac/Diablo. tBID 15-19 diablo IAP-binding mitochondrial protein Homo sapiens 125-129 32345661-5 2020 tBid-induced mitochondrial outer membrane permeabilization was also required to drive SMAC release and relieve inhibitor of apoptosis protein inhibition of caspase-3, thereby allowing caspase-3 auto-processing to the fully active p17/p12 form. tBID 0-4 diablo IAP-binding mitochondrial protein Homo sapiens 86-90 11782443-5 2002 Release of Smac/DIABLO from mitochondria through the TRAIL-caspase-8-tBid-Bax cascade is required to remove the inhibitory effect of XIAP and allow apoptosis to proceed. tBID 69-73 diablo IAP-binding mitochondrial protein Homo sapiens 11-15 11782443-5 2002 Release of Smac/DIABLO from mitochondria through the TRAIL-caspase-8-tBid-Bax cascade is required to remove the inhibitory effect of XIAP and allow apoptosis to proceed. tBID 69-73 diablo IAP-binding mitochondrial protein Homo sapiens 16-22 24464226-2 2014 Truncated Bid (tBid) induces Bax/Bak-dependent mitochondrial outer membrane permeability and the release of cytochrome c and Smac/Diablo. tBID 15-19 diablo IAP-binding mitochondrial protein Homo sapiens 130-136 15661737-3 2005 Synthetic HN peptide binds purified Bid and tBid in vitro and blocks tBid-induced release of cytochrome c and SMAC from isolated mitochondria, whereas mutant peptides that fail to bind Bid or tBid lack this activity. tBID 69-73 diablo IAP-binding mitochondrial protein Homo sapiens 110-114 15661737-3 2005 Synthetic HN peptide binds purified Bid and tBid in vitro and blocks tBid-induced release of cytochrome c and SMAC from isolated mitochondria, whereas mutant peptides that fail to bind Bid or tBid lack this activity. tBID 69-73 diablo IAP-binding mitochondrial protein Homo sapiens 110-114 18084240-7 2008 When incubated with tBid, mitochondria isolated from U18666A-treated cells showed a delay in the release of Smac/Diablo and Cytochrome c, as well as in Bax oligomerization. tBID 20-24 diablo IAP-binding mitochondrial protein Homo sapiens 108-112 18084240-7 2008 When incubated with tBid, mitochondria isolated from U18666A-treated cells showed a delay in the release of Smac/Diablo and Cytochrome c, as well as in Bax oligomerization. tBID 20-24 diablo IAP-binding mitochondrial protein Homo sapiens 113-119 15537572-7 2005 In summary, whereas tBid permeabilizes the outer membrane to cytochrome c, Smac/DIABLO, and Omi/HtrA2, the release of cytochrome c during apoptosis will be underestimated unless sufficient ionic strength is maintained to overcome the electrostatic association of cytochrome c with membranes. tBID 20-24 diablo IAP-binding mitochondrial protein Homo sapiens 75-79 15537572-7 2005 In summary, whereas tBid permeabilizes the outer membrane to cytochrome c, Smac/DIABLO, and Omi/HtrA2, the release of cytochrome c during apoptosis will be underestimated unless sufficient ionic strength is maintained to overcome the electrostatic association of cytochrome c with membranes. tBID 20-24 diablo IAP-binding mitochondrial protein Homo sapiens 80-86 11741882-0 2002 Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. tBID 18-22 diablo IAP-binding mitochondrial protein Homo sapiens 48-52 11741882-0 2002 Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. tBID 18-22 diablo IAP-binding mitochondrial protein Homo sapiens 53-59 11741882-3 2002 Using green fluorescent protein fusion proteins and immunostaining in individual permeabilized HepG2 cells, first we demonstrated that truncated Bid (15.5-kDa C-terminal fragment, tBid) evoked a rapid and essentially complete release of cytochrome c and Smac/DIABLO from every mitochondrion. tBID 180-184 diablo IAP-binding mitochondrial protein Homo sapiens 254-258 11741882-3 2002 Using green fluorescent protein fusion proteins and immunostaining in individual permeabilized HepG2 cells, first we demonstrated that truncated Bid (15.5-kDa C-terminal fragment, tBid) evoked a rapid and essentially complete release of cytochrome c and Smac/DIABLO from every mitochondrion. tBID 180-184 diablo IAP-binding mitochondrial protein Homo sapiens 259-265 11741882-4 2002 To establish at a resolution of seconds the kinetics of tBid-induced cytochrome c and Smac/DIABLO release and depolarization, we monitored the mitochondrial membrane potential (DeltaPsi(m)) fluorimetrically in permeabilized cells and applied a rapid filtration method to obtain cytosolic fractions for Western blotting. tBID 56-60 diablo IAP-binding mitochondrial protein Homo sapiens 86-90 11741882-4 2002 To establish at a resolution of seconds the kinetics of tBid-induced cytochrome c and Smac/DIABLO release and depolarization, we monitored the mitochondrial membrane potential (DeltaPsi(m)) fluorimetrically in permeabilized cells and applied a rapid filtration method to obtain cytosolic fractions for Western blotting. tBID 56-60 diablo IAP-binding mitochondrial protein Homo sapiens 91-97 11741882-7 2002 In response to 2.5 nm tBid, cytochrome c release started after a 10 s delay, displayed rapid progression, and was complete at 50-70 s. Release of Smac/DIABLO was synchronized with cytochrome c release, whereas the loss of DeltaPsi(m) lagged slightly behind cytochrome c release. tBID 22-26 diablo IAP-binding mitochondrial protein Homo sapiens 146-150 11741882-7 2002 In response to 2.5 nm tBid, cytochrome c release started after a 10 s delay, displayed rapid progression, and was complete at 50-70 s. Release of Smac/DIABLO was synchronized with cytochrome c release, whereas the loss of DeltaPsi(m) lagged slightly behind cytochrome c release. tBID 22-26 diablo IAP-binding mitochondrial protein Homo sapiens 151-157 11741882-9 2002 Thus, tBid-induced permeabilization of the outer membrane permits rapid release of cytochrome c and Smac/DIABLO from all domains of the intermembrane space. tBID 6-10 diablo IAP-binding mitochondrial protein Homo sapiens 100-104 11741882-9 2002 Thus, tBid-induced permeabilization of the outer membrane permits rapid release of cytochrome c and Smac/DIABLO from all domains of the intermembrane space. tBID 6-10 diablo IAP-binding mitochondrial protein Homo sapiens 105-111