PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23387849-3	2013	OBJECTIVES: Here we elucidated the molecular mechanisms by which OSS activates EC Smad1/5 and its in vivo functional role.	OSS	65-68	SMAD family member 1	Homo sapiens	82-89	
23387849-7	2013	OSS induced sustained BMPRIB-alphav beta3 integrin association in ECs, which was mediated by the intracytoplasmic kinase domain of BMPRII and subsequently activated the Shc/focal adhesion kinase (FAK)/extracellular signal-regulated kinase (ERK) cascade, leading to Smad1/5 activation.	OSS	0-3	SMAD family member 1	Homo sapiens	265-272	
23387849-8	2013	This OSS-activation of Smad1/5 induced its association with and activation of runt-related transcription factor-2 (Runx2), leading to activations of mammalian target of rapamycin (mTOR) and p70S6 kinase (p70S6K), a pathway critical for EC proliferation in response to OSS.	OSS	5-8	SMAD family member 1	Homo sapiens	23-30	
23387849-8	2013	This OSS-activation of Smad1/5 induced its association with and activation of runt-related transcription factor-2 (Runx2), leading to activations of mammalian target of rapamycin (mTOR) and p70S6 kinase (p70S6K), a pathway critical for EC proliferation in response to OSS.	OSS	268-271	SMAD family member 1	Homo sapiens	23-30	
22550179-4	2012	Application of OSS (0.5 +- 4 dyn/cm(2)) causes the sustained activation of Smad1/5 in ECs through activations of mammalian target of rapamycin and p70S6 kinase, leading to up-regulation of cyclin A and down-regulations of p21(CIP1) and p27(KIP1) and, hence, EC cycle progression.	OSS	15-18	SMAD family member 1	Homo sapiens	75-82	
22550179-6	2012	Immunohistochemical and en face examinations of the experimentally stenosed abdominal aorta in rats show high levels of phospho-Smad1/5 in ECs at poststenotic sites, where OSS occurs.	OSS	172-175	SMAD family member 1	Homo sapiens	128-135	
22550179-8	2012	Transfecting ECs with Smad1/5-specific small interfering RNAs inhibits the OSS-induced EC cycle progression.	OSS	75-78	SMAD family member 1	Homo sapiens	22-29