PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35636449-8 2022 The present review suggests that TXA has an anti-inflammatory effect in patients undergoing orthopaedic surgery illustrated by decreased levels of C-reactive protein and interleukin-6 in patients receiving TXA compared with patients receiving no or lower doses of TXA. Tranexamic Acid 264-267 interleukin 6 Homo sapiens 170-183 32347005-6 2020 RESULTS: The CRP and IL-6 levels were lower in the TXA + DEX group than in the TXA group (all P < 0.001) at 24 h, 48 h, and 72 h postoperatively. Tranexamic Acid 51-54 interleukin 6 Homo sapiens 21-25 35636449-8 2022 The present review suggests that TXA has an anti-inflammatory effect in patients undergoing orthopaedic surgery illustrated by decreased levels of C-reactive protein and interleukin-6 in patients receiving TXA compared with patients receiving no or lower doses of TXA. Tranexamic Acid 33-36 interleukin 6 Homo sapiens 170-183 35636449-8 2022 The present review suggests that TXA has an anti-inflammatory effect in patients undergoing orthopaedic surgery illustrated by decreased levels of C-reactive protein and interleukin-6 in patients receiving TXA compared with patients receiving no or lower doses of TXA. Tranexamic Acid 206-209 interleukin 6 Homo sapiens 170-183 33013880-11 2020 The fold decrease in plasma IL-6 was significantly less in the 4 g TXA group [1.36 (0.87-2.42)] compared to the placebo group [0.46 (0.19-1.69)] at 72 h post-TXA (p = 0.028). Tranexamic Acid 67-70 interleukin 6 Homo sapiens 28-32 33013880-11 2020 The fold decrease in plasma IL-6 was significantly less in the 4 g TXA group [1.36 (0.87-2.42)] compared to the placebo group [0.46 (0.19-1.69)] at 72 h post-TXA (p = 0.028). Tranexamic Acid 158-161 interleukin 6 Homo sapiens 28-32 31441836-9 2019 CONCLUSION: The combined administration of TXA + Dexa significantly reduced the level of postoperative CRP and IL-6, relieve postoperative pain, ameliorate the incidence of POVN, provide additional analgesic and antiemetic effects, reduce postoperative fatigue, and improve ROM, without increasing the risk of complications in primary TKA. Tranexamic Acid 43-46 interleukin 6 Homo sapiens 111-115 29914535-5 2018 RESULTS: After the bone cut and surgery, TXA significantly increased MCP-1, TNF-alpha, IL-1beta and IL-6 levels compared to non-TXA patients, which was further amplified postoperatively. Tranexamic Acid 41-44 interleukin 6 Homo sapiens 100-104 12154423-9 2002 MEASUREMENTS AND MAIN RESULTS: In the control and tranexamic acid groups, tumor necrosis factor-alpha, IL-6, and IL-10 secretion by whole blood cell cultures were rapidly decreased, whereas IL-8 secretion was unaffected. Tranexamic Acid 50-65 interleukin 6 Homo sapiens 103-107 30578968-8 2019 Furthermore, the anti-inflammatory effects of TXA were associated with the inhibition of TLR2, pro-inflammatory cytokines (IL-6 and TNFalpha) and chemokines (CCL10) expression in LL37-activated HaCaT cells. Tranexamic Acid 46-49 interleukin 6 Homo sapiens 123-140 30238726-11 2018 Univariate analysis showed that the level of IL-6 in serum at 1 day after operation was significantly higher in variables as follows: age, diagnosis, history of lung infection, range of motion, preoperative levels of CRP and IL-6 in serum, intravenous dosage of tranexamic acid and dexamethasone on day of operation ( P<0.05). Tranexamic Acid 262-277 interleukin 6 Homo sapiens 45-49