PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32308543-4 2020 VEGF165 also promoted tyrosine phosphorylation of VEGFR-1 and VEGFR-2 in HUVECs, which was again abolished by TA. Tranexamic Acid 110-112 fms related receptor tyrosine kinase 1 Homo sapiens 50-57 32308543-5 2020 TA further showed similar effects to neutralization of VEGFR-1 and VEGFR-2 in inhibiting cell proliferation, migration, invasion and tube formation of HUVECs induced by VEGF165, suggesting that TA could inhibit angiogenesis by targeting VEGFRs in HUVECs. Tranexamic Acid 194-196 fms related receptor tyrosine kinase 1 Homo sapiens 55-62 32308543-6 2020 In addition, VEGF165 enhanced the expression of VEGFRs and promoted tyrosine phosphorylation of VEGFR-1 and VEGFR-2 in normal human melanocytes, which were also attenuated by TA. Tranexamic Acid 175-177 fms related receptor tyrosine kinase 1 Homo sapiens 96-103 32308543-7 2020 Furthermore, TA showed similar effects to neutralization of VEGFR-1 and VEGFR-2 in inhibiting tyrosinase activity, melanin production and even melanogenic proteins induced by VEGF165, suggesting that TA could reduce melanogenesis via inhibiting activation of VEGFRs and subsequent expression of melanogenic proteins in melanocytes. Tranexamic Acid 200-202 fms related receptor tyrosine kinase 1 Homo sapiens 60-67