PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10579326-2 1999 In subconfluent cultures, wortmannin, LY294002, and rapamycin reversed insulin- and EGF-induced [3H]thymidine incorporation into DNA. Tritium 97-99 epidermal growth factor like 1 Rattus norvegicus 84-87 11263267-5 2000 In contrary, 65% or 75% EGF- or tetradecanoylphorbol acetate (TDPA, formally called PMA)--stimulated CCDPK activity and 38% or 42% [3H]thymidine incorporation treated by PDBU were inhibited, respectively. Tritium 132-134 epidermal growth factor like 1 Rattus norvegicus 24-27 10954043-5 2000 The EGF-induced increase in [3H]-labeled mucin in the full-thickness mucosa was not suppressed by either NG-nitro-L-arginine (10(-5) M) or 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (10(-5) M). Tritium 29-31 epidermal growth factor like 1 Rattus norvegicus 4-7 9729576-6 1998 Forty-eight hours postaerosolization of rat lungs with EGF there was an approximately 40% increase in active Na+ transport and lung liquid clearance compared with control rats, in the absence of changes in 22Na+, [3H]mannitol, and albumin permeabilities. Tritium 214-216 epidermal growth factor like 1 Rattus norvegicus 55-58 10576546-6 1999 In EGF-treated astrocytes, [3H]DA uptake increased in a time-dependent manner until 72 h in both the presence and absence of Na +. Tritium 28-30 epidermal growth factor like 1 Rattus norvegicus 3-6 9016808-5 1997 EGF (0.5-2.5 ng/ml) stimulated [3H]thymidine incorporation and increased DNA content of cultures. Tritium 32-34 epidermal growth factor like 1 Rattus norvegicus 0-3 8591854-4 1996 Activin A, at a concentration of 10(-9) mol/L, blocked the effect of epidermal growth factor (EGF) on DNA synthesis, that was assessed by measuring [3H] thymidine incorporation and nuclear labeling, almost completely, and NE reversed the inhibitory effect of activin A on DNA synthesis. Tritium 149-151 epidermal growth factor like 1 Rattus norvegicus 69-92 8591854-4 1996 Activin A, at a concentration of 10(-9) mol/L, blocked the effect of epidermal growth factor (EGF) on DNA synthesis, that was assessed by measuring [3H] thymidine incorporation and nuclear labeling, almost completely, and NE reversed the inhibitory effect of activin A on DNA synthesis. Tritium 149-151 epidermal growth factor like 1 Rattus norvegicus 94-97 8206647-3 1994 Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) added singly caused significant increases relative to control in both the uptake of [3H]thymidine into the cellular DNA of subconfluent monolayers and of [3H]proline into collagenase-sensitive protein. Tritium 157-159 epidermal growth factor like 1 Rattus norvegicus 0-23 8550051-6 1996 Infusion of EGF, HGF, uPA, or any combination thereof for up to 7 days resulted in increased numbers of [3H]thymidine-labeled ductal and periductal cells expanding into the liver acinus. Tritium 105-107 epidermal growth factor like 1 Rattus norvegicus 12-15 8206647-3 1994 Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) added singly caused significant increases relative to control in both the uptake of [3H]thymidine into the cellular DNA of subconfluent monolayers and of [3H]proline into collagenase-sensitive protein. Tritium 157-159 epidermal growth factor like 1 Rattus norvegicus 25-28 8206647-3 1994 Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) added singly caused significant increases relative to control in both the uptake of [3H]thymidine into the cellular DNA of subconfluent monolayers and of [3H]proline into collagenase-sensitive protein. Tritium 227-229 epidermal growth factor like 1 Rattus norvegicus 0-23 8206647-3 1994 Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) added singly caused significant increases relative to control in both the uptake of [3H]thymidine into the cellular DNA of subconfluent monolayers and of [3H]proline into collagenase-sensitive protein. Tritium 227-229 epidermal growth factor like 1 Rattus norvegicus 25-28 7908802-3 1994 Epidermal growth factor (EGF) (50 ng/ml) and platelet-derived growth factor (PDGF)-BB induced an elevation of the [3H]thymidine incorporation into cell DNA from 154 +/- 7 (basal value) to 1270 +/- 95 and 1552 +/- 178 cpm/microgram protein (mean +/- S.D., n = 3). Tritium 115-117 epidermal growth factor like 1 Rattus norvegicus 0-23 7908802-3 1994 Epidermal growth factor (EGF) (50 ng/ml) and platelet-derived growth factor (PDGF)-BB induced an elevation of the [3H]thymidine incorporation into cell DNA from 154 +/- 7 (basal value) to 1270 +/- 95 and 1552 +/- 178 cpm/microgram protein (mean +/- S.D., n = 3). Tritium 115-117 epidermal growth factor like 1 Rattus norvegicus 25-28 7908802-5 1994 In contrast to phenylephrine, oxymetazoline caused an elevation of the PDGF-BB- and EGF-induced [3H]thymidine incorporation to 1561 +/- 143 and 2086 +/- 235 (means S.D., n = 3), respectively. Tritium 97-99 epidermal growth factor like 1 Rattus norvegicus 84-87 7908802-6 1994 In addition, EGF (1 to 50 ng/ml) induced a dose-dependent increase of [3H]thymidine incorporation from 154 +/- 7 (basal value) to 486 +/- 35 (1 ng/ml), 912 +/- 74 (5 ng/ml), 1019 +/- 40 (25 ng/ml) and 1270 +/- 95 (50 ng/ml) cpm/microgram protein (mean +/- S.D.). Tritium 71-73 epidermal growth factor like 1 Rattus norvegicus 13-16 7908802-7 1994 In the presence of 10(-6) M oxymetazoline, 1, 5, 25 and 50 ng/ml EGF caused an increase of [3H]thymidine incorporation to 633 +/- 101, 1124 +/- 87, 1231 +/- 101, and 1561 +/- 89 cpm/microgram protein (mean +/- S.D.). Tritium 92-94 epidermal growth factor like 1 Rattus norvegicus 65-68 1444891-5 1992 Inhibitory effects of insulin on the [3H]-thymidine incorporation were potentiated by EGF, though EGF alone strongly increased the effect; whereas the addition of TGF-beta had no significant effect on the insulin action. Tritium 38-40 epidermal growth factor like 1 Rattus norvegicus 86-89 8235720-3 1993 The results showed that EGF inhibited the 3H-TdR incorporation into DNA of granulosa cells, while the progesterone production was increased due to enhanced 3 beta-HSD activity. Tritium 42-44 epidermal growth factor like 1 Rattus norvegicus 24-27 1358576-5 1992 CdCl2, at concentrations that range from 0.25 to 2 microM, was found to inhibit, in a dose-dependent fashion, the EGF-induced DNA synthesis (as judged by [3H]thymidine incorporation) in the cells. Tritium 155-157 epidermal growth factor like 1 Rattus norvegicus 114-117 1380434-6 1992 In particular, addition of increasing concentrations of EGF from 0.25-10 ng/ml to a constant concentration of 50 ng/ml IGF-I resulted in significant potentiation of [3H]thymidine incorporation of astroglial cells. Tritium 166-168 epidermal growth factor like 1 Rattus norvegicus 56-59 1757491-3 1991 Analysis at the single-cell level by [3H]thymidine autoradiography indicated that in 40-50% of the EGF-treated cell population the entry into S phase is delayed. Tritium 38-40 epidermal growth factor like 1 Rattus norvegicus 99-102 1800771-7 1991 Treatment of mesencephalic cultures with EGF (3 ng/ml) for 20 days stimulated [3H]dopamine and [14C]GABA uptakes about 4-fold. Tritium 79-81 epidermal growth factor like 1 Rattus norvegicus 41-44 1651844-1 1991 Treatment of pituitary GH4C1 cells with epidermal growth factor (EGF) caused up to a 60% reduction in the amount of [3H]MeTRH bound to specific TRH receptors. Tritium 117-119 epidermal growth factor like 1 Rattus norvegicus 40-63 1651844-1 1991 Treatment of pituitary GH4C1 cells with epidermal growth factor (EGF) caused up to a 60% reduction in the amount of [3H]MeTRH bound to specific TRH receptors. Tritium 117-119 epidermal growth factor like 1 Rattus norvegicus 65-68 1407562-9 1992 The proliferative response of these non-neuronal cells to epidermal growth factor, as assessed by [3H]thymidine incorporation, was evident after three days of epidermal growth factor application, persisted thereafter, and could be antagonized by the inclusion of the antimitotic 5-fluorodeoxyuridine. Tritium 99-101 epidermal growth factor like 1 Rattus norvegicus 58-81 1407562-9 1992 The proliferative response of these non-neuronal cells to epidermal growth factor, as assessed by [3H]thymidine incorporation, was evident after three days of epidermal growth factor application, persisted thereafter, and could be antagonized by the inclusion of the antimitotic 5-fluorodeoxyuridine. Tritium 99-101 epidermal growth factor like 1 Rattus norvegicus 159-182 1412511-5 1992 Nevertheless, addition of 5 nM EGF increased [3H]thymidine incorporation by 22% in the control, but not in the BP- or nicotine-treated group. Tritium 46-48 epidermal growth factor like 1 Rattus norvegicus 31-34 1347714-5 1992 Stimulation of [3H]thymidine incorporation into the DNA by CPA was only observed in the presence of epidermal growth factor (EGF) (10 ng/ml) and insulin (10 mU/ml). Tritium 16-18 epidermal growth factor like 1 Rattus norvegicus 100-123 1347714-5 1992 Stimulation of [3H]thymidine incorporation into the DNA by CPA was only observed in the presence of epidermal growth factor (EGF) (10 ng/ml) and insulin (10 mU/ml). Tritium 16-18 epidermal growth factor like 1 Rattus norvegicus 125-128 2011856-3 1991 EGF at a concentration of 10 ng/ml was found to stimulate DNA synthesis (as judged by [3H]thymidine incorporation) in growth-arrested NRK-49F cells. Tritium 87-89 epidermal growth factor like 1 Rattus norvegicus 0-3 2123407-2 1990 In the current study using glass beads to permeabilize [3H]- or [14C]-arachidonate labelled mesangial cells we demonstrate that guanine nucleotides modulate the EGF-mediated stimulation of arachidonic acid release (75% inhibition with 100 microM GDP beta S and 108% augmentation with 100 microM GTP gamma S). Tritium 56-58 epidermal growth factor like 1 Rattus norvegicus 161-164 1705563-3 1991 Thyrotropin-releasing hormone (TRH), tetradecanoylphorbol acetate (TPA), and epidermal growth factor (EGF), each known to enhance calcium entry in GH4 cells, decrease GH4 cell number and incorporation of [3H]-thymidine. Tritium 205-208 epidermal growth factor like 1 Rattus norvegicus 77-100 1705563-3 1991 Thyrotropin-releasing hormone (TRH), tetradecanoylphorbol acetate (TPA), and epidermal growth factor (EGF), each known to enhance calcium entry in GH4 cells, decrease GH4 cell number and incorporation of [3H]-thymidine. Tritium 205-208 epidermal growth factor like 1 Rattus norvegicus 102-105 1670924-4 1991 These morphological changes were accompanied by the functional expression of D2 dopamine receptors as shown by the presence of a specific, saturable, and stereoselective high affinity binding for [3H]spiroperidol in epidermal growth factor-treated cells and by the fact that the selective D2 agonist quinpirole recovered the property to inhibit PRL secretion in the cell cultures exposed to the neurotrophic factor. Tritium 197-199 epidermal growth factor like 1 Rattus norvegicus 216-239 2396670-5 1990 Exogenous EGF resulted in greater levels of renal [3H]thymidine incorporation into renal proximal tubule cells compared with those observed in nontreated animals at several time points in the first 48 h after toxic injury. Tritium 51-53 epidermal growth factor like 1 Rattus norvegicus 10-13 2306559-2 1990 Maximal effect of aFGF and EGF on DNA synthesis measured by [3H]thymidine incorporation was observed after 18 h. aFGF stimulated DNA synthesis by 3.5-fold with an ED50 of 0.75 ng/ml while a 2.3-fold EGF stimulation was recorded with an ED50 of 0.067 ng/ml. Tritium 61-63 epidermal growth factor like 1 Rattus norvegicus 27-30 2158429-10 1990 [3H]Thymidine incorporation in the presence of epidermal growth factor (50 ng/ml) was stimulated 66% by IGF-II (300 ng/ml) in control cells compared with 220% in cells from hepatectomized animals. Tritium 1-3 epidermal growth factor like 1 Rattus norvegicus 47-70 2808537-9 1989 Epidermal growth factor promoted the incorporation of [3H]-thymidine into DNA by quiescent cells, and this was also markedly stimulated when cells were plated onto ECM-coated plasticware rather than onto plastic substratum. Tritium 55-57 epidermal growth factor like 1 Rattus norvegicus 0-23 2483973-4 1989 Maximal 3H-thymidine incorporation occurred 48 hours after addition of EGF. Tritium 8-10 epidermal growth factor like 1 Rattus norvegicus 71-74 2783308-9 1989 The addition of EGF to glial cultures produced a dose-dependent stimulation of [3H]thymidine incorporation as well as the multiplication of cells over a 6-day period. Tritium 80-82 epidermal growth factor like 1 Rattus norvegicus 16-19 2741168-3 1989 Platelet-derived growth factor (PDGF), epidermal growth factor (EGF) and somatomedin-C (Sm-C) increased [3H]thymidine incorporation, an index of DNA synthesis, and cell number of rat aortic SMCs after 36 hr of incubation. Tritium 105-107 epidermal growth factor like 1 Rattus norvegicus 39-62 2741168-3 1989 Platelet-derived growth factor (PDGF), epidermal growth factor (EGF) and somatomedin-C (Sm-C) increased [3H]thymidine incorporation, an index of DNA synthesis, and cell number of rat aortic SMCs after 36 hr of incubation. Tritium 105-107 epidermal growth factor like 1 Rattus norvegicus 64-67 2470581-3 1989 However, this concentration of EGF inhibited [3H]thymidine incorporation into DNA by 44%, decreased DNA content by 20%, and increased the concentrations of amylase, chymotrypsinogen, and protein by 106%, 232%, and 42%, respectively. Tritium 46-48 epidermal growth factor like 1 Rattus norvegicus 31-34 3049121-3 1988 Hepatocyte cultures electroporated with the c-myc gene showed a potentiation of this EGF effect exhibiting rates of DNA synthesis up to 50% greater than those of control electroporated cultures, as determined by [3H]thymidine labeling of cell nuclei. Tritium 213-215 epidermal growth factor like 1 Rattus norvegicus 85-88 3260875-6 1988 Moreover, EGF (10(-7) M) stimulated [3H]arachidonate release from pre-labelled rat pituitary cells. Tritium 37-40 epidermal growth factor like 1 Rattus norvegicus 10-13 3121411-9 1987 EGF treatment did not alter cell number but slightly increased [3H]thymidine incorporation into cellular DNA. Tritium 64-66 epidermal growth factor like 1 Rattus norvegicus 0-3 3283731-5 1988 EGF significantly increased [3H]-phenylalanine incorporation into acinar protein and the specific activity of phenylalanine-acylated transfer RNA (tRNAphe), but did not change the apparent rate of protein synthesis when compared with insulin of IGF-I. Tritium 29-31 epidermal growth factor like 1 Rattus norvegicus 0-3 3499217-1 1987 Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine. Tritium 222-224 epidermal growth factor like 1 Rattus norvegicus 146-149 3548718-2 1987 Incorporation of [3H]-thymidine was stimulated 1.4-2.4 fold by insulin, insulin like growth factor (IGF), platelet derived growth factor (PDGF), epidermal growth factor (EGF) and 2% fetal calf serum (FCS) respectively. Tritium 18-20 epidermal growth factor like 1 Rattus norvegicus 145-168 3548718-2 1987 Incorporation of [3H]-thymidine was stimulated 1.4-2.4 fold by insulin, insulin like growth factor (IGF), platelet derived growth factor (PDGF), epidermal growth factor (EGF) and 2% fetal calf serum (FCS) respectively. Tritium 18-20 epidermal growth factor like 1 Rattus norvegicus 170-173 2426089-9 1986 The peak effect on DNA and S phase was consistently at 48 h. Epidermal growth factor (EGF) was shown to increase [3H]Tdr incorporation in a nondose-dependent fashion (10(-10) to 5 X 10(-9) M gave approximately 250% of control) over 1, 2, 3, 5, and 7 days, with no increase in DNA and a slight decrement in the concentration of cAMP. Tritium 114-116 epidermal growth factor like 1 Rattus norvegicus 61-84 2426089-9 1986 The peak effect on DNA and S phase was consistently at 48 h. Epidermal growth factor (EGF) was shown to increase [3H]Tdr incorporation in a nondose-dependent fashion (10(-10) to 5 X 10(-9) M gave approximately 250% of control) over 1, 2, 3, 5, and 7 days, with no increase in DNA and a slight decrement in the concentration of cAMP. Tritium 114-116 epidermal growth factor like 1 Rattus norvegicus 86-89 6307497-9 1983 In both the normal and malignant cell strains, EGF was found to increase incorporation of 3H-labeled thymidine into acid-precipitable macromolecules. Tritium 90-92 epidermal growth factor like 1 Rattus norvegicus 47-50 3489609-3 1986 EGF stimulated cellular proliferation and incorporation of [3H]thymidine and [3H]leucine into the cells in a dose-dependent fashion; the approximate half-maximal stimulation was induced with 1.5 X 10(-10)M. Platelet-derived growth factor (PDGF) had an additive effect with EGF on DNA synthesis by VSMC. Tritium 60-62 epidermal growth factor like 1 Rattus norvegicus 0-3 3489609-3 1986 EGF stimulated cellular proliferation and incorporation of [3H]thymidine and [3H]leucine into the cells in a dose-dependent fashion; the approximate half-maximal stimulation was induced with 1.5 X 10(-10)M. Platelet-derived growth factor (PDGF) had an additive effect with EGF on DNA synthesis by VSMC. Tritium 78-80 epidermal growth factor like 1 Rattus norvegicus 0-3 6604568-3 1983 Twenty-four hour treatment of UMR 106 cells with EGF in doses ranging from 10(-12) M to 2 X 10(-8) M stimulated the incorporation of [3H]thymidine and DNA synthesis in a dose-dependent manner. Tritium 134-136 epidermal growth factor like 1 Rattus norvegicus 49-52 6313708-6 1983 FSH-sensitive adenylate cyclase activity, as measured by the conversion of (3H)-ATP to (3H)-cAMP, was inhibited by GnRHa and EGF at 48 h of culture. Tritium 75-80 epidermal growth factor like 1 Rattus norvegicus 125-128 93054-1 1979 Epidermal growth factor stimulated both [3H]thymidine uptake and proliferation of rat AH66 hepatoma cells. Tritium 41-43 epidermal growth factor like 1 Rattus norvegicus 0-23