PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10733008-2 2000 Binding site densities for the PTBR ligand [3H-PK11195] are increased in autopsied brain tissue from PSE patients as well as in the brains of animals with experimental chronic liver failure. Tritium 44-46 translocator protein Homo sapiens 31-35 14675564-3 2004 Evaluation of kinetic parameters of PBR was performed using [3H]PK11195, as specific radioligand compared with 15 healthy volunteers. Tritium 61-63 translocator protein Homo sapiens 36-39 12020611-4 2002 Increased densities of binding sites for the PTBR ligand [3H]-PK11195 are also observed in these conditions as well as in brains of animals with acute liver failure, congenital urea cycle disorders and in patients who died in hepatic coma. Tritium 58-60 translocator protein Homo sapiens 45-49 11697575-1 2001 The binding characteristics of the pBR (peripheral benzodiazepine receptor) inverse agonist, [3H]-Ro 5-4864, were examined in patients diagnosed as generalized anxiety disorder. Tritium 94-96 translocator protein Homo sapiens 35-38 11697575-1 2001 The binding characteristics of the pBR (peripheral benzodiazepine receptor) inverse agonist, [3H]-Ro 5-4864, were examined in patients diagnosed as generalized anxiety disorder. Tritium 94-96 translocator protein Homo sapiens 40-74 18690876-4 2008 In our previous studies we investigated the presence of nuclear PBR in different hepatic tumour cell lines with regard to binding to [3H] PK 11,195 and protein analysis. Tritium 134-136 translocator protein Homo sapiens 64-67 15769477-3 2005 In our study we investigated the presence of perinuclear/nuclear PBR in different hepatic tumor cell lines with regard to binding to [3H] PK 11195 and protein analysis. Tritium 134-136 translocator protein Homo sapiens 65-68 11893007-5 2002 Receptor sites were evaluated using an in vitro binding assay and the selective PTBR ligand [3H]PK11195. Tritium 93-95 translocator protein Homo sapiens 80-84 11044655-3 2000 Binding capacity for the PBR ligand [3H]-Ro5-4864 was strongly related to the phase of the cell cycle with a positive correlation (r=0.98) with a high percentage of cells in S phase. Tritium 37-39 translocator protein Homo sapiens 25-28 11215759-2 2000 We have recently reported a significant decrease in the density of BZRP labeled by [3H] PK 11195 in the postmortem brain of chronic schizophrenics, suggesting that dysfunctions of the BZRP are involved in the pathophysiology of schizophrenia. Tritium 84-86 translocator protein Homo sapiens 67-71 11215759-2 2000 We have recently reported a significant decrease in the density of BZRP labeled by [3H] PK 11195 in the postmortem brain of chronic schizophrenics, suggesting that dysfunctions of the BZRP are involved in the pathophysiology of schizophrenia. Tritium 84-86 translocator protein Homo sapiens 184-188 9527511-7 1997 The novel peripheral-type benzodiazepine receptor ligand 2-(4-fluorophenyl)-N,N-di-n-hexyl-1H-indole-3-acetamide (FGIN1-27) displaced only [3H]PK11195 binding with high potency. Tritium 140-142 translocator protein Homo sapiens 10-49 9540054-2 1998 In vitro binding of [3H]PK-11195[1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3-isoguinol ine carboxamide] to human gliomas in radioligand binding studies revealed a significantly higher level (about 3 fold) of PBR binding sites in both low grade and high grade gliomas as compared to normal cortex. Tritium 21-23 translocator protein Homo sapiens 211-214 10330690-2 1999 Receptor autoradiography of [3H]-PK11195, a PBR selective ligand, indicated dose-dependent increases throughout the nigrostriatal dopaminergic system as early as 24 h after MPTP administration (10-80 mg/kg), which persisted for at least 21 days. Tritium 29-31 translocator protein Homo sapiens 44-47 10579463-4 1999 Ro5-4864 (IC50 17.3 nM) and PK 11195 (IC50 12.3 nM) were able to compete with [3H]Ro5-4864 for binding, indicating specificity of interaction with PBR. Tritium 79-81 translocator protein Homo sapiens 147-150 9606532-5 1998 Kinetic binding properties of pBR were measured using 3H-PK11195 as a ligand. Tritium 54-56 translocator protein Homo sapiens 30-33 9513188-6 1998 Mitochondrial benzodiazepine receptor pharmacology was studied using [3H] PK11195 binding to cancer cell homogenates and isolated kidney mitochondrial membranes. Tritium 70-72 translocator protein Homo sapiens 0-37 8866701-7 1996 [3H]PK 11195 was used to label platelet PBR. Tritium 1-3 translocator protein Homo sapiens 40-43 8221702-4 1993 It appears that the PBR are composed of three subunits: an 18-kDa subunit that binds isoquinoline carboxamide derivatives; a 30-kDa subunit that binds benzodiazepines; and a 32-kDa subunit labeled by the benzodiazepine [3H]AHN 086, the voltage-dependent anion channel. Tritium 220-222 translocator protein Homo sapiens 20-23 7617701-4 1995 Mechanically induced increases in activity by forced running stress results in a significant reduction in [3H]Ro 5-4864 binding to PBR in olfactory bulb, opposite to the PBR changes in this tissue following forced cold-water swim stress. Tritium 107-109 translocator protein Homo sapiens 131-134 7714547-3 1994 PBR Bmax was assessed by [3H]PK-11195 in vitro binding in surgical specimens and GUR was measured by Positron Emission Tomography with [18F]2-Fluorodeoxyglucose before the surgery. Tritium 26-28 translocator protein Homo sapiens 0-3 8121239-4 1994 [3H] Ro 5-4864, an agonist, showed a low affinity (KD = 188.38 +/- 16.46 nM) for human peripheral-type benzodiazepine receptor subtype. Tritium 1-3 translocator protein Homo sapiens 87-126 8307574-9 1993 Expression of PBR cDNA in pCMV5 vectors transfected into COS-1 cells resulted in increased binding of [3H]PK11195, but expression of PBR-S did not. Tritium 103-105 translocator protein Homo sapiens 14-17 1667758-4 1991 After galactose induction, the transformed cells expressed a functional hPBR which displayed a Kd for the specific peripheral-type ligand [3H]PK11195 of 9.9 +/- 1.3 nM and a maximal binding capacity of 249,300 +/- 50,400 sites/cell. Tritium 139-141 translocator protein Homo sapiens 72-76 1322664-12 1992 Although the difference between values for displacing potency and ability to inhibit cell multiplication cannot be explained as yet, it is interesting that all PBR-ligands followed the same sequence in displacing [3H]Pk 11195 and inhibiting cell multiplication and that central type ligands were ineffective in both assays. Tritium 214-216 translocator protein Homo sapiens 160-163 1326278-6 1992 The PBR ligand [3H]PK 11195 had high affinity for the expressed receptor in COS-1 cells, but the affinities of a pair of isoquinoline propanamide enantiomers differed remarkably in expressed and endogenous human PBR. Tritium 16-18 translocator protein Homo sapiens 4-7 2167748-4 1990 Using radioligand binding techniques, we have demonstrated that 6 out of 6 glioblastoma (GBM) specimens had high concentrations of PBR [( 3H]PK 11195 binding sites) which were significantly greater than in 5 normal human frontal cortex samples. Tritium 138-140 translocator protein Homo sapiens 131-134 1847384-5 1991 Scatchard analysis in both cell lines revealed one class of specific binding sites for [3H] flunitrazepam verified as being MBR by displacement studies with a series of MBR ligands. Tritium 88-90 translocator protein Homo sapiens 124-127 1847384-5 1991 Scatchard analysis in both cell lines revealed one class of specific binding sites for [3H] flunitrazepam verified as being MBR by displacement studies with a series of MBR ligands. Tritium 88-90 translocator protein Homo sapiens 169-172 2167748-8 1990 The ligand recognition site of the PBR in human GBM tissue was photoaffinity labeled using [3H]PK 14105, a nitrophenyl analogue of PK 11195. Tritium 92-94 translocator protein Homo sapiens 35-38 31578541-10 2019 TSPO radioligand binding was increased up to seven times for 3H-PBR28 and up to two times for 3H-PK11195 in active lesions and the centre of chronic active lesions and a strong correlation was found between the radioligand binding signal for both tracers and the number of TSPO+ cells across all of the tissues examined. Tritium 61-63 translocator protein Homo sapiens 0-4 2826958-1 1988 The characteristics of [3H]Ro 5-4864 binding to "peripheral" benzodiazepine receptors (PBR) in the central nervous system and peripheral tissues were examined after chemical sympathectomy with 6-hydroxydopamine (6-OHDA). Tritium 24-26 translocator protein Homo sapiens 48-85 2826958-1 1988 The characteristics of [3H]Ro 5-4864 binding to "peripheral" benzodiazepine receptors (PBR) in the central nervous system and peripheral tissues were examined after chemical sympathectomy with 6-hydroxydopamine (6-OHDA). Tritium 24-26 translocator protein Homo sapiens 87-90 34248642-5 2021 The results imply that koumine might be a high-affinity ligand of TSPO and that it likely acts as a PAM since it could delay the dissociation of 3H-PK11195 from TSPO. Tritium 145-147 translocator protein Homo sapiens 66-70 34248642-5 2021 The results imply that koumine might be a high-affinity ligand of TSPO and that it likely acts as a PAM since it could delay the dissociation of 3H-PK11195 from TSPO. Tritium 145-147 translocator protein Homo sapiens 161-165 3132026-2 1988 It was found that all tested benzodiazepines suppressed [3H]-thymidine incorporation into the DNA of glioma cells, the effects being stronger in case of peripheral-type benzodiazepine receptor ligands. Tritium 57-59 translocator protein Homo sapiens 153-192 31578541-10 2019 TSPO radioligand binding was increased up to seven times for 3H-PBR28 and up to two times for 3H-PK11195 in active lesions and the centre of chronic active lesions and a strong correlation was found between the radioligand binding signal for both tracers and the number of TSPO+ cells across all of the tissues examined. Tritium 94-96 translocator protein Homo sapiens 0-4 24625077-4 2014 METHODS: TSPO binding of DPA-713, DPA-714 and PK11195 were assessed by in vitro competition studies with [3H]DPA-713 using human macrophage THP-1 cells and CD14+ monocytes from healthy volunteers. Tritium 106-108 translocator protein Homo sapiens 9-13 30126329-6 2018 We also investigated the effects of haloperidol ( n=9) or placebo ( n=10) on the expression of the translocator protein 18 kDa (TSPO) using autoradiography with [3H]PBR28, a TSPO ligand used in human positron emission tomography (PET) studies. Tritium 162-164 translocator protein Homo sapiens 99-126 30126329-6 2018 We also investigated the effects of haloperidol ( n=9) or placebo ( n=10) on the expression of the translocator protein 18 kDa (TSPO) using autoradiography with [3H]PBR28, a TSPO ligand used in human positron emission tomography (PET) studies. Tritium 162-164 translocator protein Homo sapiens 128-132 27939322-8 2017 Using [3H]PK 11195 as a radio ligand, we found that TSPO binding sites are not uniform, but separated into two sub-populations, one with high affinity (respective Kd and Bmax values of 1.40+-0.08nM and 1586+-48 fmol/mg protein), another with lower affinity (respective Kd and Bmax values of 61+-5nM and 26260+-1050 fmol/mg protein). Tritium 7-9 translocator protein Homo sapiens 52-56 28875261-4 2018 Here we report that [3H]-DPA-713 in the presence of cholesterol or PK11195 has an accelerated dissociation rate from TSPO in platelets isolated from individuals with the T/T genotype. Tritium 21-23 translocator protein Homo sapiens 117-121 24814875-5 2014 Transient overexpression of TSPO enhanced efflux (E%) of [3H]cholesterol to apoA-I, HDL and human serum compared with empty vector (EV) controls, whereas gene knockdown of TSPO achieved the converse. Tritium 58-60 translocator protein Homo sapiens 28-32 24814875-6 2014 Ligation of TSPO (using PK11195, FGIN-1-27 and flunitrazepam) triggered increases in [3H]cholesterol efflux, an effect that was amplified in TSPO-overexpressing macrophages. Tritium 86-88 translocator protein Homo sapiens 12-16 18806692-4 2008 Successful TSPO knockdown was characterized by reduction of 20% in TSPO RNA levels, 50% in protein expression of the TSPO, and 50% in binding with the TSPO ligand, [3H]PK 11195. Tritium 165-167 translocator protein Homo sapiens 11-15 18054208-6 2008 METHODS: The equilibrium binding parameters of the specific TSPO ligand [3H]PK 11195 were estimated on platelet membranes from 40 adult outpatients with DSM-IV diagnosis of MDD, with or without separation anxiety symptoms, and 20 healthy controls. Tritium 73-75 translocator protein Homo sapiens 60-64