PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9122262-4	1997	EEDQ decreased the specific binding of [3H]5HT to 5HT2c receptors.	Tritium	39-42	5-hydroxytryptamine receptor 2C	Homo sapiens	50-55	
11465634-3	2001	METHODS: Since 5-HT2C receptors are positively coupled to phospholipase C (PLC), their activation was determined by depletion of membrane-bound pools of pre-labelled [3H]phosphotidylinositol ([3H]PI).	Tritium	167-169	5-hydroxytryptamine receptor 2C	Homo sapiens	15-21	
11465634-3	2001	METHODS: Since 5-HT2C receptors are positively coupled to phospholipase C (PLC), their activation was determined by depletion of membrane-bound pools of pre-labelled [3H]phosphotidylinositol ([3H]PI).	Tritium	193-195	5-hydroxytryptamine receptor 2C	Homo sapiens	15-21	
9831908-5	1998	5-HT stimulated [3H]-inositol phosphate ([3H]-IPx) production at both the 5-HT2C (pEC50=8.03+/-0.15) and 5-HT2A receptors (pEC50=7.15+/-0.08), with maximal responses occurring after exposure to 1 microM and 10 microM 5-HT, respectively.	Tritium	17-19	5-hydroxytryptamine receptor 2C	Homo sapiens	74-80	
9831908-5	1998	5-HT stimulated [3H]-inositol phosphate ([3H]-IPx) production at both the 5-HT2C (pEC50=8.03+/-0.15) and 5-HT2A receptors (pEC50=7.15+/-0.08), with maximal responses occurring after exposure to 1 microM and 10 microM 5-HT, respectively.	Tritium	42-44	5-hydroxytryptamine receptor 2C	Homo sapiens	74-80	
9050900-4	1997	In accord with the electrophysiological results, fluoxetine inhibited the binding of [3H]5HT to 5HT2C receptors expressed in HeLa cells (Ki approximately 65-97 nM), and the binding to 5HT receptors in rat cortex membranes was also inhibited but less efficiently (Ki approximately 56 microM).	Tritium	86-88	5-hydroxytryptamine receptor 2C	Homo sapiens	96-101	
8780834-2	1996	CHO cells, transfected with a cDNA clone for the 5-HT2C receptor, expressed 287 fmol/mg of the receptor protein as determined by mianserin-sensitive [3H]-mesulergine binding (kd = 0.49 nM).	Tritium	150-152	5-hydroxytryptamine receptor 2C	Homo sapiens	49-55	
1358117-5	1992	The affinity of [3H]SCH39166 for 5-HT2 and 5-HT1c receptors is at least an order of magnitude lower than the affinity of [3H]SCH23390 for these same receptor sites.	Tritium	17-19	5-hydroxytryptamine receptor 2C	Homo sapiens	43-49	
8643087-3	1996	5-HT2C receptor ligands modulated [3H]thymidine incorporation, DNA amounts, and cell number in serum-starved NIH-3T3 fibroblasts transfected with 5-HT2C receptor cDNA.	Tritium	35-37	5-hydroxytryptamine receptor 2C	Homo sapiens	0-6	
8643087-7	1996	The rank order of potencies of inverse agonists to decrease basal [3H]thymidine incorporation was consistent with their rank order to decrease basal 5-HT2C receptor-mediated phosphoinositide hydrolysis.	Tritium	67-70	5-hydroxytryptamine receptor 2C	Homo sapiens	149-155	
8401931-2	1993	[3H]-5-hydroxytryptamine (5-HT) has been shown to radiolabel at least five types of 5-HT binding sites in mammalian brain tissue, 5-HT1A, 5-HT1C, 5-HT1D and 5-HT1D and 5-HT1E (Frazer et al., 1990).	Tritium	1-3	5-hydroxytryptamine receptor 2C	Homo sapiens	138-144	
2213830-4	1990	Whereas tryptamine derivatives generally display little selectivity for the various populations of 5-HT receptors, N1-n-propyl-5-methoxy-alpha-methyltryptamine (3h) binds with significant affinity (Ki = 12 nM) and selectivity at 5-HT2 receptors relative to 5-HT1A (Ki = 7100 nM), 5-HT1B (Ki = 5000 nM), 5-HT1C (Ki = 120 nM), and 5-HT1D (Ki greater than 10,000 nM) receptors.	Tritium	161-163	5-hydroxytryptamine receptor 2C	Homo sapiens	303-309	
2193614-2	1990	Although these sites have similar pharmacology to D1 dopamine receptors, the high-affinity component of 3H-SCH-23390 binding in the choroid plexus has been identified as the 5-HT1c subtype of serotonin receptor.	Tritium	104-106	5-hydroxytryptamine receptor 2C	Homo sapiens	174-180	
2533325-4	1989	In addition, 5-HT1A and 5-HT1C sites were directly visualized with the more selective radioligands [3H]8-OH-DPAT and [3H]mesulergine, respectively.	Tritium	100-103	5-hydroxytryptamine receptor 2C	Homo sapiens	24-30	
2530468-7	1989	A small proportion (less than 10%) of [3H]5-HT sites in the frontal cortex appeared to be of the 5-HT1C subtype, as these sites were displaced with high affinity by mianserin.	Tritium	39-41	5-hydroxytryptamine receptor 2C	Homo sapiens	97-103	
2966310-1	1988	In human caudate and cortex membranes, [3H]serotonin ([3H]5-HT) labels 5-HT1A and 5-HT1C recognition sites which show nanomolar affinity for 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-HT1B binding could be identified.	Tritium	40-42	5-hydroxytryptamine receptor 2C	Homo sapiens	82-88	
3141589-2	1988	[3H]5-HT binding, in the presence of pindolol (to block 5-HT1A and 5-HT1B receptors) and mesulergine (to block 5-HT1C receptors), was specific, saturable, reversible, and of high affinity.	Tritium	1-3	5-hydroxytryptamine receptor 2C	Homo sapiens	111-117	
2966310-1	1988	In human caudate and cortex membranes, [3H]serotonin ([3H]5-HT) labels 5-HT1A and 5-HT1C recognition sites which show nanomolar affinity for 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-HT1B binding could be identified.	Tritium	55-57	5-hydroxytryptamine receptor 2C	Homo sapiens	82-88