PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2610822-5	1989	These results strengthen the notion that the [3H]-DHA sites with low agonist affinity for isoproterenol represent 5-HT1B receptors induced following a reduction of serotonergic neuronal function.	Tritium	46-48	5-hydroxytryptamine receptor 1B	Homo sapiens	114-120	
3815073-1	1987	High-affinity [3H]serotonin (5-hydroxytryptamine, 5-HT) binding sites from human frontal cortex can be divided into at least 3 pharmacological subtypes (5-HT1A, 5-HT1B and 5-HT3) based on affinity for [3H]serotonin and spiperone.	Tritium	15-17	5-hydroxytryptamine receptor 1B	Homo sapiens	161-167	
2532791-2	1989	Binding parameters and in vitro receptor autoradiography were performed by using two different ligands which have been shown to label 5-HT1B sites, namely [3H]5-HT, in presence of 100 nM 8-OH-DPAT, and [125I]cyanopindolol, in presence of 10 microM (-)isoproterenol.	Tritium	156-158	5-hydroxytryptamine receptor 1B	Homo sapiens	134-140	
2966310-1	1988	In human caudate and cortex membranes, [3H]serotonin ([3H]5-HT) labels 5-HT1A and 5-HT1C recognition sites which show nanomolar affinity for 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-HT1B binding could be identified.	Tritium	40-42	5-hydroxytryptamine receptor 1B	Homo sapiens	234-240	
2966310-1	1988	In human caudate and cortex membranes, [3H]serotonin ([3H]5-HT) labels 5-HT1A and 5-HT1C recognition sites which show nanomolar affinity for 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-HT1B binding could be identified.	Tritium	55-57	5-hydroxytryptamine receptor 1B	Homo sapiens	234-240	
3141589-2	1988	[3H]5-HT binding, in the presence of pindolol (to block 5-HT1A and 5-HT1B receptors) and mesulergine (to block 5-HT1C receptors), was specific, saturable, reversible, and of high affinity.	Tritium	1-3	5-hydroxytryptamine receptor 1B	Homo sapiens	67-73	
19401496-5	2009	[N-methyl-(3)H(3)]-AZ10419369 showed saturable single-site high-affinity in vitro binding (guinea pig, K(d) = 0.38 and human, K(d) = 0.37) to guinea pig or human 5-HT(1B) receptors in recombinant membranes and high-affinity (K(d) = 1.9 nM) saturable (B(max) = 0.099 pmol/mg protein) binding in membranes from guinea pig striatum.	Tritium	10-14	5-hydroxytryptamine receptor 1B	Homo sapiens	162-169	
3719375-6	1986	[3H]5-HT was used to label both 5-HT1A and 5-HT1B receptor subtypes.	Tritium	1-3	5-hydroxytryptamine receptor 1B	Homo sapiens	43-49	
10188970-2	1999	The inhibition by 5-HT of the K+ (15 mM)-evoked overflow of [3H]5-HT was antagonized by the 5-HT1B/5-HT1D receptor ligand GR 127935, which was ineffective on its own; this drug was previously found to behave as a full agonist at the h5-HT1D heteroreceptor regulating glutamate release.	Tritium	61-63	5-hydroxytryptamine receptor 1B	Homo sapiens	92-98	
11641558-6	2001	Here, 3H-sumatriptan binding at sites similar to mammalian 5-HT(1B/D) receptors was significantly higher in forebrain regions of submissive anoles than in dominant cagemates; this receptor site seemed pharmacologically more like a 5-HT(1B) than a 5-HT(1D) receptor.	Tritium	6-8	5-hydroxytryptamine receptor 1B	Homo sapiens	59-66	
11641558-6	2001	Here, 3H-sumatriptan binding at sites similar to mammalian 5-HT(1B/D) receptors was significantly higher in forebrain regions of submissive anoles than in dominant cagemates; this receptor site seemed pharmacologically more like a 5-HT(1B) than a 5-HT(1D) receptor.	Tritium	6-8	5-hydroxytryptamine receptor 1B	Homo sapiens	231-238	
10193663-0	1999	Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors.	Tritium	85-87	5-hydroxytryptamine receptor 1B	Homo sapiens	116-122	
10193663-3	1999	Kinetic studies comparing the binding of [3H]eletriptan and [3H]sumatriptan to the human recombinant 5-HT1B and 5-HT1D receptors expressed in HeLa cells revealed that both radioligands bound with high specificity (>90%) and reached equilibrium within 10-15 min.	Tritium	42-44	5-hydroxytryptamine receptor 1B	Homo sapiens	101-107	
10193663-3	1999	Kinetic studies comparing the binding of [3H]eletriptan and [3H]sumatriptan to the human recombinant 5-HT1B and 5-HT1D receptors expressed in HeLa cells revealed that both radioligands bound with high specificity (>90%) and reached equilibrium within 10-15 min.	Tritium	61-63	5-hydroxytryptamine receptor 1B	Homo sapiens	101-107	
10193663-4	1999	However, [3H]eletriptan had over 6-fold higher affinity than [3H]sumatriptan at the 5-HT1D receptor (K(D)): 0.92 and 6.58 nM, respectively) and over 3-fold higher affinity than [3H]sumatriptan at the 5-HT1B receptor (K(D): 3.14 and 11.07 nM, respectively).	Tritium	10-12	5-hydroxytryptamine receptor 1B	Homo sapiens	200-206	
9225278-8	1997	The proportion of [3H]sumatriptan binding sites displaced by 5-CT and insensitive to ketanserin, corresponding to 5-HT1B receptors, was, in general, the most abundant, ranging from 43.8% in substantia gelatinosa to 69.9% in the periaqueductal grey.	Tritium	19-21	5-hydroxytryptamine receptor 1B	Homo sapiens	114-120	
9774213-5	1998	Using transfected cells expressing either 5-HT1B or 5-HT1D receptors, it was shown that 5-HT-moduline prevents the binding of [3H]5-HT to 5-HT1B as well as to 5-HT1D receptors with similar biochemical characteristics: the IC50 of the peptide was 1.2x10(-12) M for 5-HT1B and 9x10(-13) M for 5-HT1D receptors.	Tritium	127-129	5-hydroxytryptamine receptor 1B	Homo sapiens	42-48	
9774213-5	1998	Using transfected cells expressing either 5-HT1B or 5-HT1D receptors, it was shown that 5-HT-moduline prevents the binding of [3H]5-HT to 5-HT1B as well as to 5-HT1D receptors with similar biochemical characteristics: the IC50 of the peptide was 1.2x10(-12) M for 5-HT1B and 9x10(-13) M for 5-HT1D receptors.	Tritium	127-129	5-hydroxytryptamine receptor 1B	Homo sapiens	138-144	
9774213-5	1998	Using transfected cells expressing either 5-HT1B or 5-HT1D receptors, it was shown that 5-HT-moduline prevents the binding of [3H]5-HT to 5-HT1B as well as to 5-HT1D receptors with similar biochemical characteristics: the IC50 of the peptide was 1.2x10(-12) M for 5-HT1B and 9x10(-13) M for 5-HT1D receptors.	Tritium	127-129	5-hydroxytryptamine receptor 1B	Homo sapiens	138-144	
9774213-6	1998	The observed effect corresponds to a marked decrease of the maximal binding for [3H]5-HT on 5-HT1B (-51.2 +/- 1%) as well as 5-HT1D binding (-47.2 +/- 7.7% of the control binding) whereas the affinity of 5-HT is increased by a factor close to 3.	Tritium	81-83	5-hydroxytryptamine receptor 1B	Homo sapiens	92-98	
9225276-7	1997	Guinea pig 5-HT1B and 5-HT1D receptor genes were transiently expressed in Cos-7 cells and their binding properties were evaluated using [3H]5-HT.	Tritium	137-139	5-hydroxytryptamine receptor 1B	Homo sapiens	11-17	
9225278-0	1997	Differential distribution of [3H]sumatriptan binding sites (5-HT1B, 5-HT1D and 5-HT1F receptors) in human brain: focus on brainstem and spinal cord.	Tritium	30-32	5-hydroxytryptamine receptor 1B	Homo sapiens	60-66	
9606727-0	1997	Autoradiographic mapping of 5-HT1B- and 5-HT1D receptors in human brain using [3H]alniditan, a new radioligand.	Tritium	79-81	5-hydroxytryptamine receptor 1B	Homo sapiens	28-34	
7589183-5	1995	These results indicate that [3H]sumatriptan labels predominantly 5-HT1D alpha and/or 5-HT1D beta (but not 5-HT1A or 5-HT1F) receptor subtypes in cat brain stem and spinal cord.	Tritium	29-31	5-hydroxytryptamine receptor 1B	Homo sapiens	85-96	
8491253-5	1993	In contrast, [3H]5-HT binding determined in the presence of drugs masking 5-HT1A, 5-HT1B and 5-HT1C receptors, is markedly (50%) reduced 3 days after the viral infection.	Tritium	14-16	5-hydroxytryptamine receptor 1B	Homo sapiens	82-88	
8218242-4	1993	Agonist radioligand [3H]5-HT binding studies showed that the expressed 5-HT1B and m5-HT1B receptors displayed the characteristic pharmacological profile of the neuronal 5-HT1B receptor.	Tritium	21-23	5-hydroxytryptamine receptor 1B	Homo sapiens	71-77	
8218242-4	1993	Agonist radioligand [3H]5-HT binding studies showed that the expressed 5-HT1B and m5-HT1B receptors displayed the characteristic pharmacological profile of the neuronal 5-HT1B receptor.	Tritium	21-23	5-hydroxytryptamine receptor 1B	Homo sapiens	83-89	
2213830-4	1990	Whereas tryptamine derivatives generally display little selectivity for the various populations of 5-HT receptors, N1-n-propyl-5-methoxy-alpha-methyltryptamine (3h) binds with significant affinity (Ki = 12 nM) and selectivity at 5-HT2 receptors relative to 5-HT1A (Ki = 7100 nM), 5-HT1B (Ki = 5000 nM), 5-HT1C (Ki = 120 nM), and 5-HT1D (Ki greater than 10,000 nM) receptors.	Tritium	161-163	5-hydroxytryptamine receptor 1B	Homo sapiens	280-286