PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30587573-5	2019	We found that ATP binding is sufficient to switch SUR1 alone between inward- or outward-facing conformations with low or high dissociation constant, KD , values for the conformation-sensitive channel antagonist [3H]glibenclamide ([3H]GBM), indicating that ATP can act as a pure agonist.	Tritium	212-214	ATP binding cassette subfamily C member 8	Homo sapiens	50-54	
30587573-5	2019	We found that ATP binding is sufficient to switch SUR1 alone between inward- or outward-facing conformations with low or high dissociation constant, KD , values for the conformation-sensitive channel antagonist [3H]glibenclamide ([3H]GBM), indicating that ATP can act as a pure agonist.	Tritium	231-233	ATP binding cassette subfamily C member 8	Homo sapiens	50-54	
30587573-6	2019	Assembly with Kir6.2 reduced SUR1"s KD for [3H]GBM.	Tritium	44-46	ATP binding cassette subfamily C member 8	Homo sapiens	29-33	
30587573-8	2019	Moreover, ATP/GBM site coupling was constrained in WT SUR1/WT Kir6.2 channels; ATP-bound channels had a lower KD for [3H]GBM than ATP-bound SUR1.	Tritium	118-120	ATP binding cassette subfamily C member 8	Homo sapiens	54-58	
30587573-8	2019	Moreover, ATP/GBM site coupling was constrained in WT SUR1/WT Kir6.2 channels; ATP-bound channels had a lower KD for [3H]GBM than ATP-bound SUR1.	Tritium	118-120	ATP binding cassette subfamily C member 8	Homo sapiens	140-144	
12031979-10	2002	[(3)H]glibenclamide binding to membranes from HEK293 cells transfected with SUR1 was displaced by NNC 55-9216 (IC(50) = 105 micromol/l), and this effect was impaired when NBD2 of SUR1 was replaced by that of SUR2A.	Tritium	2-5	ATP binding cassette subfamily C member 8	Homo sapiens	76-80	
19154434-3	2009	This study investigates the relation between the recovery of channel activity from glibenclamide inhibition and the dissociation rate of [(3)H]-glibenclamide from the channel at 37 degrees C. EXPERIMENTAL APPROACH: K(IR)6.2, K(IR)6.2DeltaN5 or K(IR)6.2DeltaN10 (the latter lacking amino-terminal residues 2-5 or 2-10 respectively) were coexpressed with SUR1 in HEK cells.	Tritium	137-143	ATP binding cassette subfamily C member 8	Homo sapiens	353-357	
12031979-10	2002	[(3)H]glibenclamide binding to membranes from HEK293 cells transfected with SUR1 was displaced by NNC 55-9216 (IC(50) = 105 micromol/l), and this effect was impaired when NBD2 of SUR1 was replaced by that of SUR2A.	Tritium	2-5	ATP binding cassette subfamily C member 8	Homo sapiens	179-183