PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21086978-1	2010	Tamoxifen (Tam), the antiestrogen used to treat estrogen receptor-positive breast cancer is a pro-drug that is converted to its major active metabolites, endoxifen and 4-hydroxy-tamoxifen (4-OH-Tam) by various biotransformation enzymes of which cytochrome P450-2D6 (CYP2D6) is key.	4'-hydroxytamoxifen	168-187	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	245-264	
21086978-1	2010	Tamoxifen (Tam), the antiestrogen used to treat estrogen receptor-positive breast cancer is a pro-drug that is converted to its major active metabolites, endoxifen and 4-hydroxy-tamoxifen (4-OH-Tam) by various biotransformation enzymes of which cytochrome P450-2D6 (CYP2D6) is key.	4'-hydroxytamoxifen	168-187	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	266-272	
25940823-3	2015	Tamoxifen is bioactivated by cytochrome P450 (CYP) enzymes such as CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4/5, resulting in the formation of active metabolites, including 4-hydroxy-tamoxifen and endoxifen.	4'-hydroxytamoxifen	173-192	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	92-98