PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31308078-6 2019 Additionally, bioinformatical analysis of indomethacin treated resistant cells revealed that indomethacin significantly activates the unfolded protein response (UPR), p53 and apoptosis pathways, and suppresses cell cycle, Myc and AR/ARV7 pathways. Indomethacin 93-105 tumor protein p53 Homo sapiens 167-170 31698450-2 2019 We previously showed that the cyclooxygenase (COX) inhibitor indomethacin prevents the ability of stromal cells to diminish p53-mediated killing of cocultured ALL cells in vitro, possibly by blocking the production of prostaglandin E2 (PGE2). Indomethacin 61-73 tumor protein p53 Homo sapiens 124-127 31698450-6 2019 The indomethacin treatment increased the level of p53 in the leukemic cells, implying that COX inhibition might reduce progression of ALL by attenuating protective paracrine PGE2 signaling from bone marrow stroma to leukemic cells. Indomethacin 4-16 tumor protein p53 Homo sapiens 50-53 31308078-6 2019 Additionally, bioinformatical analysis of indomethacin treated resistant cells revealed that indomethacin significantly activates the unfolded protein response (UPR), p53 and apoptosis pathways, and suppresses cell cycle, Myc and AR/ARV7 pathways. Indomethacin 42-54 tumor protein p53 Homo sapiens 167-170 24213373-7 2014 Induction of the DR5 by indomethacin was found to be p53 independent but dependent on the induction of CCAAT/enhancer-binding protein homologous protein (CHOP). Indomethacin 24-36 tumor protein p53 Homo sapiens 53-56 20878062-9 2010 P53 staining was decreased, while PCNA and TGFbeta3 staining were increased by indomethacin in tumor areas with high presence of COX-2, which correlated to staining of BAX, TUNEL, Bcl-2, c-jun, p21, p27, p53 and NM23. Indomethacin 79-91 tumor protein p53 Homo sapiens 204-207 10403534-11 1999 It can be concluded that wild-type p53 and/or up-regulation of c-myc is associated with indomethacin-mediated differential apoptosis in gastric epithelial cells. Indomethacin 88-100 tumor protein p53 Homo sapiens 35-38 10582657-15 1999 Induction of p53 levels was observed in WHCO3 cells exposed to GLA, AA, PGA2, indomethacin and the combination of indomethacin and GLA or AA. Indomethacin 114-126 tumor protein p53 Homo sapiens 13-16 10403534-0 1999 Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc. Indomethacin 26-38 tumor protein p53 Homo sapiens 116-119 11260862-8 2001 Indomethacin reduces the proliferation rate and induces apoptosis in CaCo-2 colon cancer cells through enhanced expression of c-myc, p53, and p27 proteins. Indomethacin 0-12 tumor protein p53 Homo sapiens 133-136 10582657-15 1999 Induction of p53 levels was observed in WHCO3 cells exposed to GLA, AA, PGA2, indomethacin and the combination of indomethacin and GLA or AA. Indomethacin 78-90 tumor protein p53 Homo sapiens 13-16