PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31698450-2	2019	We previously showed that the cyclooxygenase (COX) inhibitor indomethacin prevents the ability of stromal cells to diminish p53-mediated killing of cocultured ALL cells in vitro, possibly by blocking the production of prostaglandin E2 (PGE2).	Indomethacin	61-73	tumor protein p53	Homo sapiens	124-127	
31698450-6	2019	The indomethacin treatment increased the level of p53 in the leukemic cells, implying that COX inhibition might reduce progression of ALL by attenuating protective paracrine PGE2 signaling from bone marrow stroma to leukemic cells.	Indomethacin	4-16	tumor protein p53	Homo sapiens	50-53	
31308078-6	2019	Additionally, bioinformatical analysis of indomethacin treated resistant cells revealed that indomethacin significantly activates the unfolded protein response (UPR), p53 and apoptosis pathways, and suppresses cell cycle, Myc and AR/ARV7 pathways.	Indomethacin	93-105	tumor protein p53	Homo sapiens	167-170	
20878062-9	2010	P53 staining was decreased, while PCNA and TGFbeta3 staining were increased by indomethacin in tumor areas with high presence of COX-2, which correlated to staining of BAX, TUNEL, Bcl-2, c-jun, p21, p27, p53 and NM23.	Indomethacin	79-91	tumor protein p53	Homo sapiens	204-207	
31308078-6	2019	Additionally, bioinformatical analysis of indomethacin treated resistant cells revealed that indomethacin significantly activates the unfolded protein response (UPR), p53 and apoptosis pathways, and suppresses cell cycle, Myc and AR/ARV7 pathways.	Indomethacin	42-54	tumor protein p53	Homo sapiens	167-170	
24213373-7	2014	Induction of the DR5 by indomethacin was found to be p53 independent but dependent on the induction of CCAAT/enhancer-binding protein homologous protein (CHOP).	Indomethacin	24-36	tumor protein p53	Homo sapiens	53-56	
11260862-8	2001	Indomethacin reduces the proliferation rate and induces apoptosis in CaCo-2 colon cancer cells through enhanced expression of c-myc, p53, and p27 proteins.	Indomethacin	0-12	tumor protein p53	Homo sapiens	133-136	
10582657-15	1999	Induction of p53 levels was observed in WHCO3 cells exposed to GLA, AA, PGA2, indomethacin and the combination of indomethacin and GLA or AA.	Indomethacin	114-126	tumor protein p53	Homo sapiens	13-16	
10403534-11	1999	It can be concluded that wild-type p53 and/or up-regulation of c-myc is associated with indomethacin-mediated differential apoptosis in gastric epithelial cells.	Indomethacin	88-100	tumor protein p53	Homo sapiens	35-38	
10582657-15	1999	Induction of p53 levels was observed in WHCO3 cells exposed to GLA, AA, PGA2, indomethacin and the combination of indomethacin and GLA or AA.	Indomethacin	78-90	tumor protein p53	Homo sapiens	13-16	
10403534-0	1999	Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc.	Indomethacin	26-38	tumor protein p53	Homo sapiens	116-119