PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10491346-12 1999 In contrast with nabumatone, indomethacin decreased the plasma renin concentration. Indomethacin 29-41 renin Homo sapiens 63-68 11078175-9 2000 Addition of indomethacin to patients taking either drug caused a rise in weight and a fall in plasma renin. Indomethacin 12-24 renin Homo sapiens 101-106 25012174-6 2015 Indomethacin significantly reduced eGFR and plasma renin concentration. Indomethacin 0-12 renin Homo sapiens 51-56 1435154-8 1992 Resting plasma renin activity (PRA) and aldosterone (ALDO) were significantly reduced during the INDO trial. Indomethacin 97-101 renin Homo sapiens 15-20 8086773-5 1994 Indomethacin treatment improved serum potassium concentration and decreased plasma renin activity, plasma aldosterone concentration, and urinary prostaglandin E but had to be discontinued because of side effects. Indomethacin 0-12 renin Homo sapiens 83-88 1387841-2 1992 Two hours after a single dose of indomethacin (INDO), plasma renin activity (PRA) and atrial natriuretic peptide (ANP) levels decreased, which is consistent with an effect of lowering prostaglandins (PG). Indomethacin 33-45 renin Homo sapiens 61-66 1387841-2 1992 Two hours after a single dose of indomethacin (INDO), plasma renin activity (PRA) and atrial natriuretic peptide (ANP) levels decreased, which is consistent with an effect of lowering prostaglandins (PG). Indomethacin 47-51 renin Homo sapiens 61-66 1572111-3 1992 Drugs like indomethacin abolish the renin increment and could potentially affect both mechanisms: they inhibit cyclooxygenase but could also compete with furosemide for transport into the tubular lumen, reducing furosemide concentration at its site of action. Indomethacin 11-23 renin Homo sapiens 36-41 1836782-9 1991 Basal serum aldosterone and plasma renin activity were reduced by indomethacin. Indomethacin 66-78 renin Homo sapiens 35-40 1756437-0 1991 Effect of prostaglandin inhibition by indomethacin on plasma active and inactive renin concentration in men. Indomethacin 38-50 renin Homo sapiens 81-86 1756437-1 1991 The effect of inhibition of prostaglandin synthesis by indomethacin on active renin and on acid-activable inactive renin was studied in nine healthy, sodium-replete men, both at rest and exercise. Indomethacin 55-67 renin Homo sapiens 78-83 1756437-3 1991 Indomethacin induced a decrease in active (p = 0.004), total (p less than 0.001), and inactive (p = 0.02) renin at rest recumbent on average by 42, 19, and 8%, respectively, and at rest sitting on average by 45, 15, and 3%, respectively. Indomethacin 0-12 renin Homo sapiens 106-111 1756437-4 1991 Inhibition of prostaglandins with indomethacin reduced (p less than 0.001) active and total renin at each level of work load but not (p = 0.32) inactive renin. Indomethacin 34-46 renin Homo sapiens 92-97 1756437-5 1991 However, the exercise-induced stimulation (p less than 0.05) of active and total renin still occur during indomethacin. Indomethacin 106-118 renin Homo sapiens 81-86 2703968-6 1989 Indomethacin reduced base-line and diuretic-induced increase in plasma renin activity, plasma angiotensin II levels and urinary excretion of prostaglandin 6-keto F1 alpha to a similar extent under the two sodium diets. Indomethacin 0-12 renin Homo sapiens 71-76 2656774-7 1989 Plasma renin activity (PRA) was reduced by indomethacin pretreatment. Indomethacin 43-55 renin Homo sapiens 7-12 2254725-5 1990 Indomethacin administered acutely reduced urinary potassium and kallikrein excretion and, on chronic administration, lowered plasma renin activity, urinary chloride excretion, and raised serum potassium. Indomethacin 0-12 renin Homo sapiens 132-137 2225702-7 1990 Indomethacin did not oppose the diuretic effect of hydrochlorothiazide as assessed by weight loss but did attenuate the rise in plasma renin activity. Indomethacin 0-12 renin Homo sapiens 135-140 2655691-10 1989 The degree of inhibition of the renin responses was significantly greater in the presence of indomethacin than with either dose of ibuprofen. Indomethacin 93-105 renin Homo sapiens 32-37 2655691-13 1989 In the presence of frusemide, indomethacin had more anti-natriuretic and renin-suppressing effect than ibuprofen. Indomethacin 30-42 renin Homo sapiens 73-78 2643635-3 1989 Stimulation of renin secretion with prolonged dietary sodium restriction or amiloride resulted in marked increases in the plasma levels of prorenin, active renin, and plasma renin activity (PRA); suppression of renin secretion with indomethacin resulted in parallel decreases in prorenin, active renin, and PRA. Indomethacin 232-244 renin Homo sapiens 15-20 3038418-3 1987 Indomethacin, which decreased serum thromboxane B2 and urinary 6-keto prostaglandin-F1 alpha, reduced the plasma renin activity (PRA) increased by Enalapril. Indomethacin 0-12 renin Homo sapiens 113-118 2527542-10 1989 Correspondingly the decrease of plasma renin activity (PRA) and urinary prostaglandin excretion (PGE2) was more pronounced in those patients treated initially with indomethacin. Indomethacin 164-176 renin Homo sapiens 39-44 3652622-7 1987 Indomethacin attenuated the natriuretic and renin responses to frusemide, but did not alter urine dopamine output. Indomethacin 0-12 renin Homo sapiens 44-49 3516475-2 1986 Indomethacin, diclofenac-sodium and flurbiprofen decreased proteinuria, glomerular filtration rate, plasma renin activity and renal prostaglandin E2 excretion by 59%, 19%, 55% and 68% respectively. Indomethacin 0-12 renin Homo sapiens 107-112 3525404-1 1986 The prolonged effects (42 days) of indomethacin treatment on the renin-angiotensin-aldosterone axis, renal hemodynamics, and renal excretory function in humans were studied. Indomethacin 35-47 renin Homo sapiens 65-70 3525404-2 1986 Indomethacin produced a 41% sustained depression in the 24-hour excretion of prostaglandin E2 and a mild (7%) decrease in inulin clearance but did not affect the clearance of p-aminohippurate, the 24-hour excretion of sodium and potassium, or the basal values of plasma aldosterone; however, it decreased the basal values of renin and prevented the stimulated (3 hours of walking) responses of plasma renin activity and plasma aldosterone. Indomethacin 0-12 renin Homo sapiens 325-330 3525404-2 1986 Indomethacin produced a 41% sustained depression in the 24-hour excretion of prostaglandin E2 and a mild (7%) decrease in inulin clearance but did not affect the clearance of p-aminohippurate, the 24-hour excretion of sodium and potassium, or the basal values of plasma aldosterone; however, it decreased the basal values of renin and prevented the stimulated (3 hours of walking) responses of plasma renin activity and plasma aldosterone. Indomethacin 0-12 renin Homo sapiens 401-406 3525404-6 1986 Prolonged treatment with indomethacin also produced some of the symptoms of a syndrome of hypoprostaglandinism, such as decreased plasma renin activity, plasma aldosterone, and urinary prostaglandin E2 in association with increases in plasma potassium levels and diastolic pressure. Indomethacin 25-37 renin Homo sapiens 137-142 3510529-3 1986 After indomethacin administration to 13 cirrhotics with ascites, not only plasma renin activity and plasma aldosterone decreased significantly (p less than 0.01), but urinary kallikrein excretion also showed a small but statistically significant decrease (p less than 0.05). Indomethacin 6-18 renin Homo sapiens 81-86 3933893-6 1985 Indomethacin treatment inhibited renal cyclo-oxygenase with a 78% reduction in urinary prostaglandin E2 excretion and 89% suppression of plasma renin activity. Indomethacin 0-12 renin Homo sapiens 144-149 3884224-7 1985 Plasma renin activity was reduced from 2.3 +/- 0.8 to 1.7 +/- 0.6 nmol/L/hr by sulindac and from 2.8 +/- 0.8 to 1.5 +/- 0.5 nmol/L/hr by indomethacin. Indomethacin 137-149 renin Homo sapiens 7-12 3926508-0 1985 Active and acid-activable inactive renin during inhibition by indomethacin of prostaglandin synthesis in sodium-replete man. Indomethacin 62-74 renin Homo sapiens 35-40 3926508-1 1985 The effect of inhibition of prostaglandin synthesis by indomethacin on active renin and on acid-activable inactive renin was studied in nine healthy, sodium-replete men, both at rest and exercise. Indomethacin 55-67 renin Homo sapiens 78-83 3926508-3 1985 Indomethacin induced a decrease in active (P = 0.004), total (P less than 0.001) and inactive (P = 0.02) renin at rest recumbent and at rest, sitting. Indomethacin 0-12 renin Homo sapiens 105-110 3926508-4 1985 Inhibition of prostaglandins with indomethacin reduced (P less than 0.001) active and total renin at each level of work load but not (P = 0.32) inactive renin. Indomethacin 34-46 renin Homo sapiens 92-97 3926508-5 1985 However the exercise-induced stimulation (P less than 0.05) of active and of total renin still occur during indomethacin. Indomethacin 108-120 renin Homo sapiens 83-88 27786004-6 1984 Indomethacin thereafter reduced plasma concentration of renin, which was, however, still higher than the control level. Indomethacin 0-12 renin Homo sapiens 56-61 3901335-0 1985 [Chronization by indomethacin of the circadian rhythm of blood renin and aldosterone in a case of Bartter"s syndrome]. Indomethacin 17-29 renin Homo sapiens 63-68 6203005-3 1984 Infusion of aldosterone and an inhibitor of kallikrein, aprotinin, decreased the releases of renin, PG and kinin and infusion of aldosterone with indomethacin decreased the release of PG but increased that of kinin and urinary kallikrein without significant change in renin releases. Indomethacin 146-158 renin Homo sapiens 268-273 6432714-2 1984 Captopril antihypertensive effect and captopril-induced plasma renin increase were almost totally abolished by a short-term administration of indomethacin (50 mg t.i.d.). Indomethacin 142-154 renin Homo sapiens 63-68 6428443-3 1984 The early increase in plasma renin activity after frusemide was inhibited by indomethacin. Indomethacin 77-89 renin Homo sapiens 29-34 6425442-1 1984 The effect of fatty acid cyclooxygenase inhibition by indomethacin on active renin and on acid-activable inactive renin was studied in nine healthy men with sodium repletion, at rest and during exercise. Indomethacin 54-66 renin Homo sapiens 77-82 6425442-3 1984 During administration of indomethacin, total, active, and inactive renin levels were reduced at rest and during exercise. Indomethacin 25-37 renin Homo sapiens 67-72 6425442-4 1984 However, the exercise-induced stimulation of active and total renin still occurred during indomethacin administration. Indomethacin 90-102 renin Homo sapiens 62-67 6196593-3 1983 Indomethacin administered with captopril diminished the saluretic effect of captopril and evoked an increase in kinin, but was associated with a marked decrease in prostaglandin and renin releases, while renal vascular resistance remained decreased. Indomethacin 0-12 renin Homo sapiens 182-187 6433438-6 1984 Indomethacin thereafter reduced plasma concentration of renin, which was, however, still higher than the control level. Indomethacin 0-12 renin Homo sapiens 56-61 6758745-6 1982 In treated hypertensive subjects indomethacin (75 mg/day) did not change plasma volume, but significantly decreased plasma renin concentration. Indomethacin 33-45 renin Homo sapiens 123-128 6348468-0 1983 The effect of indomethacin on plasma renin activity response to ultrafiltration in patients undergoing hemodialysis. Indomethacin 14-26 renin Homo sapiens 37-42 7049707-2 1982 Both indomethacin and oxprenolol, as well as the two drugs combined, inhibited plasma renin activity; no change was found in urinary sodium excretion or body weight. Indomethacin 5-17 renin Homo sapiens 86-91 7105627-3 1982 After 2 days on indomethacin, both immediate and sustained diastolic pressure responses to the analogue (both, P less than 0.01) rose when the basal plasma renin activity (PRA) fell (P less than 0.05); this was associated with 56% suppression of urinary prostaglandin E excretion. Indomethacin 16-28 renin Homo sapiens 156-161 7046439-4 1982 Pretreatment with indomethacin (150 mg/day) decreased baseline plasma renin activity and reversed the hypotensive effect of the analogue of angiotensin II. Indomethacin 18-30 renin Homo sapiens 70-75 6292792-0 1982 [Effect of salbutamol, indomethacin and atenolol on plasma renin activity in patients with essential arterial hypertension]. Indomethacin 23-35 renin Homo sapiens 59-64 7045577-7 1982 However, the renin activity following metoclopramide tended to rise before, and fall after, indomethacin. Indomethacin 92-104 renin Homo sapiens 13-18 7045577-14 1982 Although the renin response to metoclopramide was altered by indomethacin, the aldosterone response to dopamine antagonism is not medicated by cyclooxygenase products or the renin-angiotension system. Indomethacin 61-73 renin Homo sapiens 13-18 6759952-0 1982 Effects of indomethacin on the renal function and renin-aldosterone system in chronic glomerulonephritis. Indomethacin 11-23 renin Homo sapiens 50-55 6759952-8 1982 The results suggest that indomethacin exerts an effect on the renin-aldosterone axis, may be a cause of drug-induced hyporeninemic hypoaldosteronism and may cause a decrease in GFR in patients with high PRA. Indomethacin 25-37 renin Homo sapiens 62-67 6802882-5 1981 In addition, indomethacin completely inhibited the bumetanide-induced increase in plasma renin activity. Indomethacin 13-25 renin Homo sapiens 89-94 7037867-6 1981 Indomethacin suppressed plasma renin activity more than carprofen. Indomethacin 0-12 renin Homo sapiens 31-36 7016059-3 1981 The patient had been receiving indomethacin, a drug known to inhibit renin production, aldosterone excretion, and prostaglandin synthetase. Indomethacin 31-43 renin Homo sapiens 69-74 6785100-5 1981 Plasma renin concentration was reduced following treatment with indomethacin. Indomethacin 64-76 renin Homo sapiens 7-12 7026199-5 1981 Moreover, the indomethacin-inhibiting effect of the fall in BP caused by captopril was more markedly exhibited in the renin-nonresponder subjects than the renin-responder subjects. Indomethacin 14-26 renin Homo sapiens 118-123 7026199-5 1981 Moreover, the indomethacin-inhibiting effect of the fall in BP caused by captopril was more markedly exhibited in the renin-nonresponder subjects than the renin-responder subjects. Indomethacin 14-26 renin Homo sapiens 155-160 7004721-9 1980 In low renin hypertensive patients who responded to captopril, the hypotensive effect was abolished after th addition of indomethacin, whereas no marked change in blood pressure was induced by indomethacin in normal renin hypertensive patients. Indomethacin 121-133 renin Homo sapiens 7-12 7048119-1 1981 In vivo administration of indomethacin (I) is associated with a decrease in basal and stimulated plasma renin activity in man and other animal species including the rat. Indomethacin 26-38 renin Homo sapiens 104-109 7004721-14 1980 The increase in renin release after the administration of captopril was inhibited by indomethacin, suggesting that an endogenous prostaglandin system may contribute to the short feedback mechanism of renin release. Indomethacin 85-97 renin Homo sapiens 16-21 7004721-14 1980 The increase in renin release after the administration of captopril was inhibited by indomethacin, suggesting that an endogenous prostaglandin system may contribute to the short feedback mechanism of renin release. Indomethacin 85-97 renin Homo sapiens 200-205 7010450-6 1980 "Supine" and "upright" plasma renin activity (PRA) and plasma norepinephrine concentration (NE) were unaltered by K+ -depletion alone but decreased with indomethacin. Indomethacin 153-165 renin Homo sapiens 30-35 451681-3 1979 Indomethacin administration corrected the defect in proximal tubular sodium resorption, but suppressed plasma renin activity and urinary aldosterone excretion only when sufficient dietary sodium was available to allow for extracellular fluid volume (ECFV) expansion. Indomethacin 0-12 renin Homo sapiens 110-115 7010681-0 1980 Indomethacin inhibits the antihypertensive effect of captopril, SQ 14225, in low renin hypertension. Indomethacin 0-12 renin Homo sapiens 81-86 7404582-4 1980 Indomethacin promptly reduced urinary excretion of sodium, potassium, chloride and PGE, and markedly suppressed the renin-aldosterone system. Indomethacin 0-12 renin Homo sapiens 116-121 6993721-6 1980 The augmented renin release following SQ 14225 administration was inhibited by indomethacin, suggesting that endogenous prostaglandin system may contribute to the negative short feedback mechanism of renin release. Indomethacin 79-91 renin Homo sapiens 14-19 6993721-6 1980 The augmented renin release following SQ 14225 administration was inhibited by indomethacin, suggesting that endogenous prostaglandin system may contribute to the negative short feedback mechanism of renin release. Indomethacin 79-91 renin Homo sapiens 200-205 6780358-0 1980 Effect of indomethacin upon the renin--angiotensin system in patients with Bartter"s syndrome. Indomethacin 10-22 renin Homo sapiens 32-37 6780358-1 1980 This study reports on the influence of indomethacin upon the renin--angiotensin system in three patients with Bartter"s syndrome. Indomethacin 39-51 renin Homo sapiens 61-66 6780358-3 1980 Pretreatment with indomethacin (75 mg/day) reversed the hypotensive effect of the analogue of angiotensin II and abolished the increase of plasma renin concentration. Indomethacin 18-30 renin Homo sapiens 146-151 6992516-8 1980 Indomethacin therapy decreased plasma renin activity (PRA), plasma aldosterone, and urinary loss of potassium and sodium, while serum potassium approached normal levels. Indomethacin 0-12 renin Homo sapiens 38-43 6251763-2 1980 Indomethacin, a blocker of prostaglandin synthesis, lowers plasma renin activity, renal prostaglandin synthesis and causes sodium retention in man. Indomethacin 0-12 renin Homo sapiens 66-71 6251763-3 1980 It is shown that the sodium retaining effect of indomethacin can be separated from its effect on plasma renin activity. Indomethacin 48-60 renin Homo sapiens 104-109 7352042-0 1980 Effect of indomethacin in two siblings with a renin-dependent hypertension, hyperaldosteronism and hypokalemia. Indomethacin 10-22 renin Homo sapiens 46-51 447034-9 1979 The administration of indomethacin caused a significant fall in plasma renin activity, 8.2 +/- 2.5 to 3.6 +/- 1.4 ng/ml/hr (P less than 0.025). Indomethacin 22-34 renin Homo sapiens 71-76 427062-4 1979 Maternal treatment with indomethacin was associated with a decrease of plasma renin activity (mean +/- SD) from 16.71 +/- 2.76 ng/ml/hour in the control group to 9.60 +/- 3.84 ng/ml/hour in the treated group. Indomethacin 24-36 renin Homo sapiens 78-83 7437238-5 1980 3 Indomethacin treatment decreased supine plasma renin activity to 50% of the level present before indomethacin treatment. Indomethacin 2-14 renin Homo sapiens 49-54 7437238-8 1980 The decrease in plasma renin activity could also contribute to the failure of indomethacin to prevent a fall in blood pressure on standing. Indomethacin 78-90 renin Homo sapiens 23-28 6992754-4 1980 The concomitant rise in plasma renin level after furosemide was also blocked by indomethacin. Indomethacin 80-92 renin Homo sapiens 31-36 7397054-5 1980 3 Indomethacin prevented the rise in plasma renin activity seen following administration of prazosin alone. Indomethacin 2-14 renin Homo sapiens 44-49 7009025-10 1980 Although administration of indomethacin lowered the basal rate of urinary prostaglandin E excretion and plasma renin activity, it did not prevent the subsequent augmentation of urinary prostaglandin E or the suppression of plasma renin activity and plasma aldosterone during the subsequent 4 h of immersion. Indomethacin 27-39 renin Homo sapiens 111-116 6989207-0 1980 Effect of indomethacin on blood pressure, catecholamine, and renin response to acute hemorrhage. Indomethacin 10-22 renin Homo sapiens 61-66 434681-5 1979 When indomethacin was withdrawn, significant kaliuresis occurred, accompanied by normalization of serum K+ and PGE2 and a supranormal rebound in renin and aldosterone levels. Indomethacin 5-17 renin Homo sapiens 145-150 434681-6 1979 Challenge with indomethacin resulted in antikaliuresis and resuppression of PGE2, renin, and aldosterone. Indomethacin 15-27 renin Homo sapiens 82-87 489926-14 1979 Indomethacin therapy resulted in a prompt drop of PG excretion rate and of plasma renin activity. Indomethacin 0-12 renin Homo sapiens 82-87 441720-2 1979 Inhibition of prostaglandin synthesis by indomethacin, confirmed by a fall in urinary excretion rate of prostaglandins E2 and F2 alpha, induced a marked decrease in plasma renin activity and aldosterone excretion rate and an increase in plasma potassium. Indomethacin 41-53 renin Homo sapiens 172-177 285569-3 1979 After a few days on peroral indomethacin medication the hypokalaemia was significantly improved, the plasma renin activity, and the urinary excretion of aldosterone, PGE2 and kallikrein were normalized in both patients. Indomethacin 28-40 renin Homo sapiens 108-113 484251-1 1979 The antihypertensive action of beta-blocking agents has been suggested to be associated with the decrease in plasma renin activity (PRA) and can be antagonized by indomethacin, a prostaglandin (PG) synthesis inhibitor. Indomethacin 163-175 renin Homo sapiens 116-121 282043-8 1978 Indomethacin produced a marked suppression of active renin, a smaller reduction in inactive renin, and a reduction of the ratio of active to total renin almost to placebo values. Indomethacin 0-12 renin Homo sapiens 53-58 282043-0 1978 Acid-activated renin responses to hydrochlorothiazide, propranol and indomethacin. Indomethacin 69-81 renin Homo sapiens 15-20 751804-2 1978 Indomethacin treatments increased serum potassium concentration and urinary Na/K ratio, and improved the response of blood pressure to angiotensin II infusion, while it decreased plasma renin activity, plasma aldosterone and urinary kallikrein. Indomethacin 0-12 renin Homo sapiens 186-191 282043-8 1978 Indomethacin produced a marked suppression of active renin, a smaller reduction in inactive renin, and a reduction of the ratio of active to total renin almost to placebo values. Indomethacin 0-12 renin Homo sapiens 92-97 282043-8 1978 Indomethacin produced a marked suppression of active renin, a smaller reduction in inactive renin, and a reduction of the ratio of active to total renin almost to placebo values. Indomethacin 0-12 renin Homo sapiens 92-97 282043-12 1978 Serum aldosterone rose with stimulation but remained elevated despite effective renin suppression with indomethacin and continuing reduced serum potassium concentration. Indomethacin 103-115 renin Homo sapiens 80-85 282044-4 1978 Active renin increased by orthostasis and frusemide and decreased by indomethacin. Indomethacin 69-81 renin Homo sapiens 7-12 282051-4 1978 Indomethacin administration reduced renin secretion by about 30% in untreated uncomplicated hypertensive patients and by about 75% in those whose renin secretion had either been stimulated or suppressed by maintained diuretic or beta-adrenoreceptor-blockade therapy. Indomethacin 0-12 renin Homo sapiens 36-41 282051-4 1978 Indomethacin administration reduced renin secretion by about 30% in untreated uncomplicated hypertensive patients and by about 75% in those whose renin secretion had either been stimulated or suppressed by maintained diuretic or beta-adrenoreceptor-blockade therapy. Indomethacin 0-12 renin Homo sapiens 146-151 412983-4 1978 Indomethacin produced notably greater suppression of urinary iPGE, greater sodium and potassium retention, greater increases in serum potassium, and decreases in plasma renin activity and in creatinine clearance than the other inhibitors. Indomethacin 0-12 renin Homo sapiens 169-174 756881-0 1978 The effect of indomethacin on plasma renin activity and urinary aldosterone of patients with essential hypertension. Indomethacin 14-26 renin Homo sapiens 37-42 756881-7 1978 The PRA unresponsiveness to indomethacin found in low renin patients may suggest renal prostaglandin deficiency. Indomethacin 28-40 renin Homo sapiens 54-59 715482-4 1978 Indomethacin therapy lowered the urinary prostaglandin excretion and the renin and aldosterone levels but did not correct the hypokalemia. Indomethacin 0-12 renin Homo sapiens 73-78 415668-6 1978 During the change-over period from indomethacin to ketoprofen the expected deterioration in clinical well-being was observed, accompanied by a rise in urinary prostaglandins and plasma renin activity. Indomethacin 35-47 renin Homo sapiens 185-190 631965-2 1978 The effect of antikaliuretic agents (spironolactone, amiloride) and antiprostaglandin agents (indomethacin, ibuprofen) on plasma renin activity and potassium metabolism was studied in a patient with familial Bartter"s syndrome. Indomethacin 94-106 renin Homo sapiens 129-134 900671-4 1977 Indomethacin significantly (P less than 0.001) reduced urinary iPGE, urinary kallikrein, and plasma renin activity, while increasing the sensitivity to intravenous angiotensin II and the serum potassium to normal. Indomethacin 0-12 renin Homo sapiens 100-105 900681-5 1977 Indomethacin also decreases the activity of the renin-angiotensin system and the excretion of renal kallikrein, perhaps related to inhibition of prostaglandin mechanisms that may participate in the release of renin and kallikrein. Indomethacin 0-12 renin Homo sapiens 48-53 900681-5 1977 Indomethacin also decreases the activity of the renin-angiotensin system and the excretion of renal kallikrein, perhaps related to inhibition of prostaglandin mechanisms that may participate in the release of renin and kallikrein. Indomethacin 0-12 renin Homo sapiens 209-214 900681-6 1977 However, additional actions of indomethacin must be considered, such as an effect of the drug on a naturally occurring renin inhibitor. Indomethacin 31-43 renin Homo sapiens 119-124 917167-1 1977 In three patients with Bartter"s syndrome, indomethacin administration resulted in the disappearance of the hypokalemic alkalosis and in a normalization of the elevated plasma renin activity. Indomethacin 43-55 renin Homo sapiens 176-181 403030-9 1977 The present data indicate that the increase in renal vascular resistance after indomethacin does not depend on the adrenergic system but may be dependent on the renin-angiotensin system. Indomethacin 79-91 renin Homo sapiens 161-166 874065-0 1977 Inhibition of the renin-aldosterone response to furosemide by indomethacin. Indomethacin 62-74 renin Homo sapiens 18-23 874065-2 1977 The increases in plasma renin activity and plasma and urinary aldosterone following acute furosemide challenge were markedly blunted in the presence of indomethacin. Indomethacin 152-164 renin Homo sapiens 24-29 821675-0 1976 Suppression of plasma renin activity by indomethacin in man. Indomethacin 40-52 renin Homo sapiens 22-27 1027654-0 1976 [Effect of indomethacin on the plasma renin activity in patients with arterial hypertension]. Indomethacin 11-23 renin Homo sapiens 38-43 821675-7 1976 Indomethacin pretreatment resulted in 60% reduction of PRA following furosemide, and three of these subjects now fell into the low renin category. Indomethacin 0-12 renin Homo sapiens 131-136 821675-10 1976 Whether indomethacin inhibits renin release by an intrarenal, PG-related mechanism or secondarily via sodium retention is discussed. Indomethacin 8-20 renin Homo sapiens 30-35 1263402-0 1976 [The effect of indomethacin on basal and stimulated plasma renin activity in normal subjects (author"s transl)]. Indomethacin 15-27 renin Homo sapiens 59-64 1263402-1 1976 The influence of indomethacin, a potent inhibitor of prostaglandin synthesis, on basal and stimulated plasma renin activities in normal human subjects was determined. Indomethacin 17-29 renin Homo sapiens 109-114 1263402-3 1976 Indomethacin led to a considerable decrease of both basal and stimulated plasma renin activity in chronic and acute experiments. Indomethacin 0-12 renin Homo sapiens 80-85 1251764-3 1976 It is proposed that the therapeutic effect of indomethacin in nephrotic syndrome is caused by its inhibiting action on renal prostaglandin synthesis, thereby potentiating the effect of the renin-angiotensin system on the kidney. Indomethacin 46-58 renin Homo sapiens 189-194 940272-1 1976 During treatment with indomethacin in a patient with Bartter"s syndrome, hypokalemia, high plasma renin concentration, hyperaldosteronism and decreased sensitivity to angiotensin infusion were corrected. Indomethacin 22-34 renin Homo sapiens 98-103 828345-3 1976 Inhibition of prostaglandin synthetase with indomethacin or ibuprofen has been shown to decrease plasma renin activity, and plasma aldosterone concentration and secretion rate, leading to a positive potassium balance and restoration of normal plasma potassium. Indomethacin 44-56 renin Homo sapiens 104-109 935121-0 1976 The effect of indomethacin on plasma renin activity in man. Indomethacin 14-26 renin Homo sapiens 37-42 1105696-1 1975 1) The influence of oral indomethacin on basal and stimulated plasma renin activity in normal human subjects was determined. Indomethacin 25-37 renin Homo sapiens 69-74 1105696-0 1975 The effect of indomethacin on plasma renin activity in man under normal conditions and after stimulation of the renin angiotensin system. Indomethacin 14-26 renin Homo sapiens 37-42 1105696-2 1975 2) Indomethacin lowers the basal plasma renin activity in man. Indomethacin 3-15 renin Homo sapiens 40-45 1105696-3 1975 3) The response of the plasma renin activity after indomethacin to physiological and pharmacological stimuli is maintained at a lower level. Indomethacin 51-63 renin Homo sapiens 30-35 1105697-2 1975 In all subjects indomethacin treatment alone resulted in a significant elevation of blood pressure and a fall in plasma renin without any change in sodium excretion. Indomethacin 16-28 renin Homo sapiens 120-125