PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26202203-6 2016 This review briefly describes the newer aspects of MGMT posttranslational regulation by ubiquitination, sumoylation and glutathionylation and reveals how the reactivity of the active site Cys145 can be exploited for potent inhibition and depletion of MGMT by thiol-reacting drugs such as the disulfiram and various dithiocarbamate derivatives. Dithiocarbamate 315-330 O-6-methylguanine-DNA methyltransferase Homo sapiens 51-55