PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20564478-0	2010	Gallic acid induces G2/M phase cell cycle arrest via regulating 14-3-3beta release from Cdc25C and Chk2 activation in human bladder transitional carcinoma cells.	Gallic Acid	0-11	checkpoint kinase 2	Homo sapiens	99-103	
20564478-8	2010	When treated with GA, phosphorylated Cdc25C can be activated by ataxia telangiectasia-mutated checkpoint kinase 2 (Chk2).	Gallic Acid	18-20	checkpoint kinase 2	Homo sapiens	115-119	
20564478-10	2010	Furthermore, treatment of the cells with a Chk2 inhibitor significantly attenuated GA-induced G2/M phase arrest.	Gallic Acid	83-85	checkpoint kinase 2	Homo sapiens	43-47	
20564478-11	2010	CONCLUSION: These results indicate that GA can induce cell cycle arrest at G2/M phase via Chk2-mediated phosphorylation of Cdc25C in a bladder transitional carcinoma cell line.	Gallic Acid	40-42	checkpoint kinase 2	Homo sapiens	90-94	
19589639-6	2009	Furthermore, gallic acid is shown to block the growth of DU145 cells at G2/M phases by activating Chk1 and Chk2 and inhibiting Cdc25C and Cdc2 activities.	Gallic Acid	13-24	checkpoint kinase 2	Homo sapiens	107-111	
17172433-0	2006	Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells.	Gallic Acid	0-11	checkpoint kinase 2	Homo sapiens	78-82	
17172433-5	2006	Further upstream, gallic acid also induced phosphorylation of both cdc25A and cdc25C via ataxia telangiectasia mutated (ATM)-checkpoint kinase 2 (Chk2) activation as a DNA damage response evidenced by increased phospho-histone 2AX (H2A.X) that is phosphorylated by ATM in response to DNA damage.	Gallic Acid	18-29	checkpoint kinase 2	Homo sapiens	146-150	
17172433-6	2006	Time kinetics of ATM phosphorylation, together with those of H2A.X and Chk2, was in accordance with an inactivating phosphorylation of cdc25A and cdc25C phosphatases and cdc2 kinase, suggesting that gallic acid increases cdc25A/C-cdc2 phosphorylation and thereby inactivation via ATM-Chk2 pathway following DNA damage that induces cell cycle arrest.	Gallic Acid	199-210	checkpoint kinase 2	Homo sapiens	71-75