PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7920694-2 1994 These drugs are thought to be activated to potentially reactive arene oxide (epoxide) metabolites by cytochrome P450-dependent monooxygenation, while liver microsomal epoxide hydrolase (mEH) plays a detoxifying role by converting such reactive intermediates to non-toxic dihydrodiols. Benzene oxide 64-75 epoxide hydrolase 1, microsomal Mus musculus 186-189 8825076-1 1995 Previous animal research has suggested that the phenytoin arene oxide metabolite is teratogenic in acute studies and that the fetal effects were increased after injecting an inhibitor of microsomal epoxide hydrolase (mEH) (Martz et al., Pharmacol Exp Ther 203:231-239, 1977, Barcellona et al., Teratog Carcinog Mutagen 7:159-168, 1987). Benzene oxide 58-69 epoxide hydrolase 1, microsomal Mus musculus 217-220