PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30228819-7 2018 As this reactive metabolite is detoxified mainly by enzymatic reactions, involving microsomal epoxide hydrolase and/or GSH-S-transferases and these enzymes are polymorphically expressed in humans, arene oxide toxicity is increased when epoxide hydrolase or GSH-S-transferases is either defective or inhibited or a depletion of intracellular glutathione levels is taking place. Benzene oxide 197-208 glutathione synthetase Homo sapiens 119-124 30228819-7 2018 As this reactive metabolite is detoxified mainly by enzymatic reactions, involving microsomal epoxide hydrolase and/or GSH-S-transferases and these enzymes are polymorphically expressed in humans, arene oxide toxicity is increased when epoxide hydrolase or GSH-S-transferases is either defective or inhibited or a depletion of intracellular glutathione levels is taking place. Benzene oxide 197-208 glutathione synthetase Homo sapiens 257-262