PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32291269-13 2020 p21 responses to high-dose SnPP and HO-1 responses to low-dose SnPP were significantly suppressed in participants with CKD versus healthy volunteers. S-Nitroso-N-propionyl-D,L-penicillamine 63-67 heme oxygenase 1 Homo sapiens 36-40 35453452-3 2022 We found that cell toxicity and mitochondrial depolarization by BTZ were increased upon inhibition of HO-1 and TLR4 by using tin protoporphyrin IX (SnPP) and TAK-242, respectively. S-Nitroso-N-propionyl-D,L-penicillamine 148-152 heme oxygenase 1 Homo sapiens 102-106 32940965-1 2020 BACKGROUND: Tin protoporphyrin (SnPP), a heme oxygenase 1 (HO-1) inhibitor, triggers adaptive tissue responses that confer potent protection against acute renal- and extra-renal tissue injuries. S-Nitroso-N-propionyl-D,L-penicillamine 32-36 heme oxygenase 1 Homo sapiens 41-57 32940965-1 2020 BACKGROUND: Tin protoporphyrin (SnPP), a heme oxygenase 1 (HO-1) inhibitor, triggers adaptive tissue responses that confer potent protection against acute renal- and extra-renal tissue injuries. S-Nitroso-N-propionyl-D,L-penicillamine 32-36 heme oxygenase 1 Homo sapiens 59-63 33668397-8 2021 An inhibitor assay using tin protoporphyrin IX (SnPP) confirmed that the enhancement of HO-1 by pre-treatment with THF protects SH-SY5y cells from CoCl2-induced neurotoxicity under hypoxic conditions. S-Nitroso-N-propionyl-D,L-penicillamine 48-52 heme oxygenase 1 Homo sapiens 88-92 33381031-8 2020 Induction of HO-1 by ferric protoporphyrin IX (FePP) inhibited TPA-induced uPAR expression, and this effect was abolished by treatment with the HO-1 inhibitor tin protoporphyrin IX (SnPP). S-Nitroso-N-propionyl-D,L-penicillamine 182-186 heme oxygenase 1 Homo sapiens 13-17 33381031-8 2020 Induction of HO-1 by ferric protoporphyrin IX (FePP) inhibited TPA-induced uPAR expression, and this effect was abolished by treatment with the HO-1 inhibitor tin protoporphyrin IX (SnPP). S-Nitroso-N-propionyl-D,L-penicillamine 182-186 heme oxygenase 1 Homo sapiens 144-148 32581238-6 2020 Induction of HO-1 by hemin or CoPP in vitro reduced production of IFN-gamma and IL-10 from healthy human PBMCs and decreased bacterial clearance activity of whole blood from healthy controls and beta-thalassaemia, while inhibition of HO-1 by SnPP enhanced both functions in healthy controls. S-Nitroso-N-propionyl-D,L-penicillamine 242-246 heme oxygenase 1 Homo sapiens 13-17 30653942-5 2019 Our results showed that hypoxia upregulates the expression of HO-1 in PDAC cells, and HO-1 inhibition using the HO-1 inhibitors zinc protoporphyrin, tin protoporphyrin IX (SnPP), and HO-1 knockout using CRISPR/Cas9 suppresses the proliferation of PDAC cells under hypoxia and sensitize them to gemcitabine under in vitro conditions. S-Nitroso-N-propionyl-D,L-penicillamine 172-176 heme oxygenase 1 Homo sapiens 86-90 30884345-13 2019 We also found that the inhibitory effect of L2H17 on the inflammatory responses was attenuated by an inhibitor of HO-1 activity, Tin protoporphyrin IX (SnPP). S-Nitroso-N-propionyl-D,L-penicillamine 152-156 heme oxygenase 1 Homo sapiens 114-118 30653942-5 2019 Our results showed that hypoxia upregulates the expression of HO-1 in PDAC cells, and HO-1 inhibition using the HO-1 inhibitors zinc protoporphyrin, tin protoporphyrin IX (SnPP), and HO-1 knockout using CRISPR/Cas9 suppresses the proliferation of PDAC cells under hypoxia and sensitize them to gemcitabine under in vitro conditions. S-Nitroso-N-propionyl-D,L-penicillamine 172-176 heme oxygenase 1 Homo sapiens 86-90 30653942-5 2019 Our results showed that hypoxia upregulates the expression of HO-1 in PDAC cells, and HO-1 inhibition using the HO-1 inhibitors zinc protoporphyrin, tin protoporphyrin IX (SnPP), and HO-1 knockout using CRISPR/Cas9 suppresses the proliferation of PDAC cells under hypoxia and sensitize them to gemcitabine under in vitro conditions. S-Nitroso-N-propionyl-D,L-penicillamine 172-176 heme oxygenase 1 Homo sapiens 86-90 32186127-7 2018 EXS-induced HO-1 expression was significantly decreased in SnPP (HO-1 inhibitor)- and HO-1 siRNA-treated cells, whereas an increase was found in cobalt protoporphyrin IX (CoPP) (HO-1 inducer)-treated cells. S-Nitroso-N-propionyl-D,L-penicillamine 59-63 heme oxygenase 1 Homo sapiens 12-16 32186127-7 2018 EXS-induced HO-1 expression was significantly decreased in SnPP (HO-1 inhibitor)- and HO-1 siRNA-treated cells, whereas an increase was found in cobalt protoporphyrin IX (CoPP) (HO-1 inducer)-treated cells. S-Nitroso-N-propionyl-D,L-penicillamine 59-63 heme oxygenase 1 Homo sapiens 65-69 32186127-7 2018 EXS-induced HO-1 expression was significantly decreased in SnPP (HO-1 inhibitor)- and HO-1 siRNA-treated cells, whereas an increase was found in cobalt protoporphyrin IX (CoPP) (HO-1 inducer)-treated cells. S-Nitroso-N-propionyl-D,L-penicillamine 59-63 heme oxygenase 1 Homo sapiens 65-69 32186127-7 2018 EXS-induced HO-1 expression was significantly decreased in SnPP (HO-1 inhibitor)- and HO-1 siRNA-treated cells, whereas an increase was found in cobalt protoporphyrin IX (CoPP) (HO-1 inducer)-treated cells. S-Nitroso-N-propionyl-D,L-penicillamine 59-63 heme oxygenase 1 Homo sapiens 65-69 25977183-5 2015 Both silencing the nuclear factor E2-related factor 2 (Nrf2) and the supplement of tin protoporphyrin IX (SnPP), a haeme oxygenase-1 (HO-1) inhibitor, cancelled the inhibitory effect of Z-lig on UVB-induced ROS upregulation in NHEKs. S-Nitroso-N-propionyl-D,L-penicillamine 106-110 heme oxygenase 1 Homo sapiens 115-139 29698685-5 2018 Treatment of cells with inhibitors of HO-1 enzyme activity, tin protoporphyrin (SnPP) and zinc protoporphyrin (ZnPP), enhanced CdCl2-induced actin cytoskeletal disorganization and the accumulation of HO-1, HSP70, aggregated protein and aggresome-like structures. S-Nitroso-N-propionyl-D,L-penicillamine 80-84 heme oxygenase 1 Homo sapiens 38-42 29698685-5 2018 Treatment of cells with inhibitors of HO-1 enzyme activity, tin protoporphyrin (SnPP) and zinc protoporphyrin (ZnPP), enhanced CdCl2-induced actin cytoskeletal disorganization and the accumulation of HO-1, HSP70, aggregated protein and aggresome-like structures. S-Nitroso-N-propionyl-D,L-penicillamine 80-84 heme oxygenase 1 Homo sapiens 200-204 27922667-6 2017 Moreover, while downregulation of HO-1 by the small-molecule inhibitor tin protoporphyrin (SnPP) promoted migration, upregulation of HO-1 by the small-molecule activator cobalt protoporphyrin (CoPP) showed the opposite effect. S-Nitroso-N-propionyl-D,L-penicillamine 91-95 heme oxygenase 1 Homo sapiens 34-38 27488535-5 2016 Inhibition of HO-1 by tin protoporphyrin (SnPP) or siRNA downregulated Pax3/7-FoxO1 target genes and induced a myogenic program in RMS. S-Nitroso-N-propionyl-D,L-penicillamine 42-46 heme oxygenase 1 Homo sapiens 14-18 26507166-12 2015 Tin protoporphyrin (SnPP)-IX, a HO-1 inhibitor, blocked the effect of hemin restoring MUC5AC protein secretion (p b 0.05) and goblet cell hyperplasia. S-Nitroso-N-propionyl-D,L-penicillamine 20-24 heme oxygenase 1 Homo sapiens 32-36 21910986-5 2011 Pretreatment with the HO-1 inhibitor, tin protoporphyrin (SnPP), attenuated the inhibitory activities of LA on LPS-induced inflammatory NO, PGE(2), IL-1beta, TNF-alpha, IL-6 and IL-12 production. S-Nitroso-N-propionyl-D,L-penicillamine 58-62 heme oxygenase 1 Homo sapiens 22-26 25615876-4 2015 Moreover, the inhibition of HO-1 expression by tin porphyrin (SnPP) abolished the protective effects of pPolyHb, which suggested that the cytoprotective effect of pPolyHb involves upregulating HO-1 and subsequently decreasing the phosphorylation of the JNK and p38 MAPK and ROS generation. S-Nitroso-N-propionyl-D,L-penicillamine 62-66 heme oxygenase 1 Homo sapiens 28-32 25615876-4 2015 Moreover, the inhibition of HO-1 expression by tin porphyrin (SnPP) abolished the protective effects of pPolyHb, which suggested that the cytoprotective effect of pPolyHb involves upregulating HO-1 and subsequently decreasing the phosphorylation of the JNK and p38 MAPK and ROS generation. S-Nitroso-N-propionyl-D,L-penicillamine 62-66 heme oxygenase 1 Homo sapiens 193-197 24763872-11 2014 Cytoprotection by BL was almost completely abolished by CC and DC and partly by SnPP, a competitive inhibitor of HO-1. S-Nitroso-N-propionyl-D,L-penicillamine 80-84 heme oxygenase 1 Homo sapiens 113-117 23977989-5 2013 Curcumin suppressed TNF-alpha- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA. S-Nitroso-N-propionyl-D,L-penicillamine 153-157 heme oxygenase 1 Homo sapiens 184-188 22492492-8 2012 The cytotoxicity of arsenite was augmented by p38 MAP kinase inhibitor SB202190 and HO-1 inhibitor tin protoporphyrin IX (SnPP), whereas p38 MAP kinase inhibitor SB202190 also inhibited HO-1 induction by NaAsO(2) . S-Nitroso-N-propionyl-D,L-penicillamine 122-126 heme oxygenase 1 Homo sapiens 84-88 23523860-5 2013 Consistent with these observations, tin protoporphyrin (SnPP), a well-established HO-1 inhibitor, was found to be much less cytotoxic than ZnPP, and docosahexaenoic acid (DHA), an HO-1 inducer, enhanced ZnPP"s cytotoxicity. S-Nitroso-N-propionyl-D,L-penicillamine 56-60 heme oxygenase 1 Homo sapiens 82-86 23523860-5 2013 Consistent with these observations, tin protoporphyrin (SnPP), a well-established HO-1 inhibitor, was found to be much less cytotoxic than ZnPP, and docosahexaenoic acid (DHA), an HO-1 inducer, enhanced ZnPP"s cytotoxicity. S-Nitroso-N-propionyl-D,L-penicillamine 56-60 heme oxygenase 1 Homo sapiens 180-184 23573137-7 2013 However, blocking HO-1 activity by tin protoporphyrin IX (SnPP), an HO-1 inhibitor, markedly abolished these beneficial effects of ALA in LPS-induced ALI. S-Nitroso-N-propionyl-D,L-penicillamine 58-62 heme oxygenase 1 Homo sapiens 18-22 23573137-7 2013 However, blocking HO-1 activity by tin protoporphyrin IX (SnPP), an HO-1 inhibitor, markedly abolished these beneficial effects of ALA in LPS-induced ALI. S-Nitroso-N-propionyl-D,L-penicillamine 58-62 heme oxygenase 1 Homo sapiens 68-72 20822529-12 2010 When pretreated with SnPP, the inhibitory effect of hemin on IL-1beta-induced NO production and iNOS expression was reversed, suggesting the involvement of HO-1. S-Nitroso-N-propionyl-D,L-penicillamine 21-25 heme oxygenase 1 Homo sapiens 156-160 21840424-10 2011 Additionally, treatment with tin-protoporphyrin (SnPP), a selective inhibitor of HO-1, reversed the alpha-iso-cubebenol-mediated inhibition of P. gingivalis LPS-induced pro-inflammatory cytokines. S-Nitroso-N-propionyl-D,L-penicillamine 49-53 heme oxygenase 1 Homo sapiens 81-85 21975817-5 2011 In addition, treatment with SnPP (tin protoporphyrin IX), a selective HO-1 inhibitor, counteracted the inhibitory effect of EG on nitrite production, suggesting that HO-1 is, at least in part, implicated in the inhibition of NO production induced by EG treatment. S-Nitroso-N-propionyl-D,L-penicillamine 28-32 heme oxygenase 1 Homo sapiens 70-74 21975817-5 2011 In addition, treatment with SnPP (tin protoporphyrin IX), a selective HO-1 inhibitor, counteracted the inhibitory effect of EG on nitrite production, suggesting that HO-1 is, at least in part, implicated in the inhibition of NO production induced by EG treatment. S-Nitroso-N-propionyl-D,L-penicillamine 28-32 heme oxygenase 1 Homo sapiens 166-170 20621084-8 2010 SnPP, a specific inhibitor of HO-1, partly blocked sappanchalcone mediated suppression of inflammatory mediator production, in LPS-stimulated HPDL cells. S-Nitroso-N-propionyl-D,L-penicillamine 0-4 heme oxygenase 1 Homo sapiens 30-34 20621084-6 2010 The cytoprotective effect of sappanchalcone was nullified by HO-1 inhibitor, Tin protoporphyrin (SnPP). S-Nitroso-N-propionyl-D,L-penicillamine 97-101 heme oxygenase 1 Homo sapiens 61-65 18357586-4 2008 Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion. S-Nitroso-N-propionyl-D,L-penicillamine 138-142 heme oxygenase 1 Homo sapiens 80-84 19681826-7 2009 HO-1 inhibition by the specific inhibitor, SnPP, completely abolished T-cell suppression and IL-10 production. S-Nitroso-N-propionyl-D,L-penicillamine 43-47 heme oxygenase 1 Homo sapiens 0-4 20536682-9 2010 The neuroprotective effect was prevented by chelerythrine, LY294002, and Sn (IV) protoporphyrin IX dichloride (SnPP), indicating the participation of the PKC/PI3K/Akt activation and induction of the antioxidant enzyme heme oxygenase-1. S-Nitroso-N-propionyl-D,L-penicillamine 111-115 heme oxygenase 1 Homo sapiens 218-234 20599745-4 2010 Treatment of HaCaT cells with tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, reversed the suppressive effect of celastrol on IFN-gamma-induced protein and mRNA expression of ICAM-1. S-Nitroso-N-propionyl-D,L-penicillamine 53-57 heme oxygenase 1 Homo sapiens 84-88 20599745-7 2010 Furthermore, blockage of HO-1 activity by SnPP and HO-1 siRNA reversed the inhibitory effect of celastrol on IFN-gamma-induced adhesion of monocytes to keratinocytes. S-Nitroso-N-propionyl-D,L-penicillamine 42-46 heme oxygenase 1 Homo sapiens 25-29 19239904-4 2009 The suppressive effect of sofalcone on NO production was attenuated by treatment with tin-protoporphyrin (SnPP), a heme-oxygenase (HO)-1 inhibitor. S-Nitroso-N-propionyl-D,L-penicillamine 106-110 heme oxygenase 1 Homo sapiens 115-136 19174156-7 2009 Treatment with SnPP, a selective inhibitor of HO-1, reversed the KB-34-mediated inhibition of nitrite production, suggesting that HO-1 plays an important role in the suppression of NO production by KB-34. S-Nitroso-N-propionyl-D,L-penicillamine 15-19 heme oxygenase 1 Homo sapiens 46-50 19174156-7 2009 Treatment with SnPP, a selective inhibitor of HO-1, reversed the KB-34-mediated inhibition of nitrite production, suggesting that HO-1 plays an important role in the suppression of NO production by KB-34. S-Nitroso-N-propionyl-D,L-penicillamine 15-19 heme oxygenase 1 Homo sapiens 130-134 18357586-4 2008 Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion. S-Nitroso-N-propionyl-D,L-penicillamine 138-142 heme oxygenase 1 Homo sapiens 108-112 18357586-4 2008 Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion. S-Nitroso-N-propionyl-D,L-penicillamine 138-142 heme oxygenase 1 Homo sapiens 108-112 15689417-8 2005 Furthermore, using tin protoporphyrin IX (SnPP) and anti-MCP-1 antibody to abolish iAs-induced HO-1 and MCP-1 activity, respectively, shows that HO-1 has protective effect against iAs-induced injury in VSMCs and MCP-1 is chemoattractive to human monocytes, THP-1. S-Nitroso-N-propionyl-D,L-penicillamine 42-46 heme oxygenase 1 Homo sapiens 95-99 17027882-7 2006 Preconditioning with low concentration SNP (0.3mM) inhibited subsequent high concentration SNP (1.5mM)-induced apoptosis, and this effect was reversed by the HO-1 inhibitor SnPP. S-Nitroso-N-propionyl-D,L-penicillamine 173-177 heme oxygenase 1 Homo sapiens 158-162 16476737-5 2006 Moreover, targeted knock-down gene expression of HO-1 by small hairpin RNA and chemical inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPP), impaired vGPCR-induced survival, proliferation, transformation, and vascular endothelial growth factor (VEGF)-A expression. S-Nitroso-N-propionyl-D,L-penicillamine 152-156 heme oxygenase 1 Homo sapiens 102-106 16547262-7 2006 Suppression of HIV replication in hemin-activated cells correlated with the induction of HO-1 and was attenuated by tin protoporphyrin (SnPP) IX, an inhibitor of HO-1 activity, suggesting a pivotal role of this endogenous enzyme in the regulation of HIV infection. S-Nitroso-N-propionyl-D,L-penicillamine 136-140 heme oxygenase 1 Homo sapiens 162-166 17976119-8 2007 However, the anti-apoptotic action of HO-1 was reversed by SnPP. S-Nitroso-N-propionyl-D,L-penicillamine 59-63 heme oxygenase 1 Homo sapiens 38-42 16474202-5 2006 SnPP (IX), the specific inhibitor of HO-1 enzymatic activity, prevented the hemin-mediated attenuation of MCP-1 mRNA expression. S-Nitroso-N-propionyl-D,L-penicillamine 0-4 heme oxygenase 1 Homo sapiens 37-41 15911218-8 2005 AZD3582-induced blockade of free-radical formation was reversed in the presence of the HO-1 inhibitor, tin protoporphyrin-IX (SnPP). S-Nitroso-N-propionyl-D,L-penicillamine 126-130 heme oxygenase 1 Homo sapiens 87-91 15689417-8 2005 Furthermore, using tin protoporphyrin IX (SnPP) and anti-MCP-1 antibody to abolish iAs-induced HO-1 and MCP-1 activity, respectively, shows that HO-1 has protective effect against iAs-induced injury in VSMCs and MCP-1 is chemoattractive to human monocytes, THP-1. S-Nitroso-N-propionyl-D,L-penicillamine 42-46 heme oxygenase 1 Homo sapiens 145-149 12709592-9 2003 The effect of a HO-1 enzyme activity inhibitor, tin protoporphyrin (SnPP), on Caco-2 cell proliferation and differentiation was examined. S-Nitroso-N-propionyl-D,L-penicillamine 68-72 heme oxygenase 1 Homo sapiens 16-20 12969148-10 2003 Tin protoporphyrin (SnPP), an inhibitor of HO function, significantly reversed the cytoprotection by HO-1. S-Nitroso-N-propionyl-D,L-penicillamine 20-24 heme oxygenase 1 Homo sapiens 101-105 8897897-3 1996 SNAP (300 microM) caused a transient increase in heme oxygenase-1 (HO-1) mRNA associated with a fivefold increase in HO activity that was completely blocked by the competitive HO inhibitor, tin protoporphyrin IX (SnPP). S-Nitroso-N-propionyl-D,L-penicillamine 213-217 heme oxygenase 1 Homo sapiens 49-65